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ERBB2
| Symbol: | ERBB2 | | Name(s): | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CD340, HER-2, HER-2/neu, HER2, NEU, NGL, TKR1, c-erb B2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18172732 |
HER2 overexpression was found in only four cases (10.5%) of the studied primary tumors and in all cases the HER2 expression was retained in the paired metastases. |
| 18211286 |
examination of role of lipids in HER1/HER2-driven progression of human breast epithelial cells towards malignancy |
| 18254960 |
We found a positive correlation between FOXM1 expression and HER2 status, pointing to a potential role of FOXM1 as a new drug target in HER2 resistant breast tumour, as FOXM1 inhibitors for cancer treatment were described recently. |
| 18182111 |
Genomic alteration of the HER2-neu and EGFR genes is frequent (25%) in ovarian cancer. |
| 18237245 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18237248 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18348656 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18174256 |
RIG1 plays a role in IFN-gamma-mediated therapy by downregulating p185 and its downstream PI3K/Akt/mTOR/VEGF-signaling pathway |
| 18056992 |
disruption of surface HSP90/HER-2 interaction leads to inhibition of heregulin-induced HER-2-HER-3 heterodimer formation, reduced HER-2 phosphorylation, and impaired downstream kinase signaling. |
| 18214297 |
Data show that serum level of soluble HER2/neu in patients with tumors characterized by high expression of this protein was significantly higher than in patients with low expression of HER2/neu and in women with benign diseases of the mammary glands. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | alpha-1-antichymotrypsin, precursor | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | - | - | Pubmed |
| HPRD | alpha-1-antichymotrypsin, precursor | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | - | - | Pubmed |
| HPRD | serpin peptidase inhibitor, clade A, member 3 precursor | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | - | - | Pubmed |
| HPRD | Angiotensin II receptor type 2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | - | - | Pubmed |
| HPRD | betacellulin | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | - | - | Pubmed |
| HPRD | betacellulin | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | - | - | Pubmed |
| HPRD | caveolin 1 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | - | - | Pubmed |
| HPRD | caveolin 1 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | - | - | Pubmed |
| HPRD | catenin, beta 1, 88kDa | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | - | - | Pubmed |
| HPRD | catenin, beta 1, 88kDa | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | - | - | Pubmed |
Recent Publications on ERBB2: |  |
Focal amplification and oncogene dependency of GAB2 in breast cancer.
DNA amplifications in breast cancer are frequent on chromosome 11q, in... | 3rd November, 2009
| Department of Pathology, Stanford University, Stanford, CA, USA.
| Oncogene. 2009 Nov 2.
DOI Direct Link |
Vascular Endothelial Growth Factor EnhancesCancer Cell Adhesion to Microvascular Endothelium in vivo.
To investigate whether vascular endothelial growth factor (VEGF) enhances... | 3rd November, 2009
| 1 University of Nevada, Las Vegas;
| Exp Physiol. 2009 Oct 30.
DOI Direct Link |
The anti-cancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition.
A wealth of data implicates that ErbB receptors have essential roles in... | 31st October, 2009
| Inflammatory Bowel Disease Center, Division of Digestive Diseases, David
| Int J Cancer. 2009 Oct 28.
DOI Direct Link |
Magnetic resonance imaging of breast cancer and correlation with prognostic factors.
BACKGROUND: Prognostic factors of breast cancer have been used for the... | 30th October, 2009
| Departments of Radiology, College of Medicine, Soonchunhyang University
| Acta Radiol. 2009 Nov;50(9):990-8.
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Estrogenic Promotion of ErbB2 Tyrosine Kinase Activity in Mammary Tumor Cells Requires Activation of ErbB3 Signaling.
Increasing evidence suggests molecular interactions between erbB2 and... | 29th October, 2009
| University of Colorado Denver School of Medicine, Aurora, Colorado;
| Mol Cancer Res. 2009 Oct 27.
DOI Direct Link |
→View more research publications. |
ERBB2 results (if any) from reagent suppliers | 
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Search Bioportfolio and other Life Science Sites for ERBB2,
or search for ERBB2 on BioPortfolio's antibody search engine.
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Recent Search Terms used to find this page: erbb2 2009 | The official name of this gene is v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 | erb2 her2 overexpressing tumor and mtor pathways | LOGiC lapatinib | foxm1 migration | HER2 neuro | erbb2 erythroblastic leukemia viral oncogene homolog 2 | erbb2 2009 | thoracic neuroglioblastoma | .
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