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ERBB4


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Symbol:ERBB4
Name(s):v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Type:protein-coding
Organism:Homo sapiens
Synonyms:HER4, MGC138404, p180erbB4
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16249994 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16402353 Observational study of gene-disease association. (HuGE Navigator)
16891421 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17487277 Observational study of gene-disease association. (HuGE Navigator)
17598910 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17903305 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
18094435 Observational study of gene-disease association. (HuGE Navigator)
18094435 The ERBB4 -782 G>T polymorphism, by virtue of its in vitro functional implication and incidence, is a risk factor for breast and colorectal cancer.
17761534 ErbB4 isoform that is proteinase cleavable but does not contain a PI3K-binding domain in its cytoplasmic tail, mediates important functions in renal epithelial cells in response to HB-EGF
17945187 Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 coupling to IL3 independence.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDbetacellulinv-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed
HPRDbetacellulinv-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed
HPRDCD44 antigenv-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed
HPRDCD44 antigenv-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed
HPRDCD44 antigen isoform 1 precursorv-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed
HPRDconnective tissue growth factorv-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed
HPRDdiscs, large homolog 1v-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed
HPRDdiscs, large homolog 1v-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed
HPRDchapsyn-110v-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed
HPRDchapsyn-110v-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed

Recent Publications on ERBB4:

Pubmed Logo
Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response.
ABSTRACT: BACKGROUND: Photodynamic therapy (PDT) is a promising cancer...
3rd November, 2009
Mol Cancer. 2009 Nov 2;8(1):94.
DOI Direct Link
Analysis of breast cancer related gene expression using natural splines and the Cox proportional hazard model to identify prognostic associations.
Many studies correlating gene expression data to clinical parameters...
28th October, 2009
Divisions of Radiation Oncology and Experimental Therapy, The Netherlands Breast Cancer Res Treat. 2009 Oct 27.
DOI Direct Link
A therapeutic opportunity in melanoma: ErbB4 makes a mark on skin.
Malignant melanomas are aggressive tumors that are largely refractory to...
16th October, 2009
Massachusetts General Hospital Cancer Center and Harvard Medical School, Cancer Cell. 2009 Oct 6;16(4):278-9.
DOI Direct Link
Dietary olive oil and corn oil differentially affect experimental breast cancer through distinct modulation of the p21ras signaling and the proliferation-apoptosis balance.
Extra-virgin olive oil (EVOO) has been hypothesized to have...
15th October, 2009
Department of Cell Biology, Physiology and Immunology, Medical Physiology Carcinogenesis. 2009 Oct 13.
DOI Direct Link
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.
Tyrosine phosphorylation is important in signaling pathways underlying...
15th October, 2009
Cancer Genetics Branch, National Human Genome Research Institute, National Nat Genet. 2009 Oct;41(10):1127-32. Epub 2009 Aug 30.
DOI Direct Link

View more research publications.

BioNews Results for ERBB4

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Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
Nature:  Oct 9 2009 3:47PM Matching: erbb4
New genetic culprit in deadly skin cancer
Charleston Post and Courier:  Sep 2 2009 1:11PM Matching: erbb4
Genetic clues may lead to new skin cancer therapies
WHBF TV:  Sep 1 2009 12:37PM Matching: erbb4
Genetic clues may lead to new skin cancer therapies
KXLY:  Sep 1 2009 5:54AM Matching: erbb4
Genetic clues may lead to new skin cancer therapies
WMCTV.com:  Sep 1 2009 3:51AM Matching: erbb4
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
ERB-B4 After Treatment With HDAC Inhibitor in ER+ Tamoxifen Refractory Breast Cancer

Patents:

Patents logo
US Patent No.Title
7514240 EGR-EGFR complex
7547781 Quinazoline based EGFR inhibitors containing a zinc binding moiety
7550598 Kinase inhibitors
7553639 Alpha-synuclein kinase
7556796 Directed complementation

View more patents.

ERBB4 results (if any) from reagent suppliers

Google CSE Logo
Phospho-HER4/ErbB4 (Tyr984) Antibody #3790
Phospho-HER4/ErbB4 (Tyr984) Antibody detects endogenous levels of HER4/ErbB4 protein only when phosphorylated on Tyr984. This antibody may cross-react with
...
http://www.cellsignal.com/products/3790.html...

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ErbB4 Antibody Bethyl Laboratories
ErbB4 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor; ...
http://www.bethyl.com/product/A300-666A...

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ErbB4 antibody, ErbB4 Antibody, Rabbit Polyclonal Antibody
Buy quality rabbit ErbB4 antibody (interacts with cross-reacts with human and mouse. not yet tested in other species.), anti-ErbB4, ErbB4 antibody, ...
http://www.genwaybio.com/product_info.php?products_id=196265...

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ErbB4 Pathway
ErbB4 has been associated with processes of cell growth, survival, chemotaxis and ... ErbB4 has been linked to terminal differentiation within some tissues.
http://www.sigmaaldrich.com/life-science/your-favorite-gene-...

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ErbB4 Antibody (C-term)
Western blot analysis of anti-ErbB4 Pab (Cat. #AP7631b) in T-47D cell lysate. ErbB4 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was ...
http://www.abgent.com/products/catalog_no/AP7631b...

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Phospho-HER4/ErbB4 (Tyr984) Antibody
Antibody detects endogenous levels of HER4/ErbB4 protein only when phosphorylated on Tyr984. ... Tyr984 of human HER4/ErbB4. Antibodies are
purified by ...
http://www.cellsignal.com/pdf/3790.pdf...

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ErbB4 Antibody (N-term)
ErbB4 Antibody (N-term) Cell Function, ErbB4 Antibody (N-term) Nuclear Signaling , ErbB4 Antibody (N-term) Protein Modification, ErbB4 Antibody (N-term) Stem ...
http://www.abgent.com/products/catalog_no/AP7631a...

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Search Bioportfolio and other Life Science Sites for ERBB4, or search for ERBB4 on BioPortfolio's antibody search engine.
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