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ABCA3
| Symbol: | ABCA3 | | Name(s): | ATP-binding cassette, sub-family A (ABC1), member 3 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ABC-C, ABC3, EST111653, LBM180, MGC166979, MGC72201, SMDP3 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18246475 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18317237 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15976379 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17660803 |
In infants with a desquamative interstitial pneumonitis pattern, surfactant or ABCA3 mutations should be evaluated. |
| 17574245 |
ABCA3 mediates ATP-dependent choline-phospholipids uptake into intracellular vesicles. |
| 17597647 |
Finding of heterozygosity for ABCA3 mutations in severely affected infants with SFTPC I73T, and independent inheritance from disease-free parents supports that ABCA3 acts as a modifier gene for the phenotype associated with an SFTPC mutation. |
| 16968533 |
ABCA17P & ABCA3 form a complex of overlapping genes at their 5' ends. Non-coding & protein-coding ABC A-transporter RNAs are expressed. This is the 1st demonstration of expression of a pseudogene & its parent from a common overlapping human DNA region. |
| 16415354 |
ABCA3 is required for lysosomal loading of phosphatidylcholine and conversion of lysosomes to lamellar body-like structures |
| 17429902 |
ABCA3 mutations were the basis for intractable respiratory distress syndrome in three Norwegian term infants |
| 16857811 |
ABCA3 has a role in drug resistance in childhood acute myeloid leukemia | →View more information from publications. |
Recent Publications on ABCA3: |  |
ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug.
Background Inhibition of BCR-ABL tyrosine kinase activity has evolved as a... | 3rd November, 2009
| Department Hematology and Oncology, Georg-August-University, Goettingen
| Haematologica. 2009 Nov;94(11):1528-36.
DOI Direct Link |
The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.
Fasudil, an inhibitor of Rho kinase, is known to suppress tumorigenicity... | 3rd November, 2009
| Department of Thoracic Surgery, Fourth Affiliated Hospital, China Medical
| Biomed Pharmacother. 2009 Oct 17.
DOI Direct Link |
Identification and Characterization of a Novel ABCA3 Mutation.
Mutations in the gene coding for ATP-binding cassette protein A3 (ABCA3)... | 29th October, 2009
| Medical College of Wisconsin.
| Physiol Genomics. 2009 Oct 27.
DOI Direct Link |
Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary Disease.
The alveolar region of the lung creates an extensive epithelial surface... | 15th October, 2009
| Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary
| Annu Rev Med. 2009 Oct 7.
DOI Direct Link |
C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia.
A number of transcriptional pathways regulating fetal lung development are... | 25th August, 2009
| Cincinnati Children's Hospital Medical Center, University of Cincinnati,
| Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L286-98. Epub 2009 May
DOI Direct Link |
→View more research publications. |
ABCA3 results (if any) from reagent suppliers | 
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ABCA3 (N-20) Antibody sc-48444
ABCA3 shRNA (h) Lentiviral Particles, sc-60113-V, 200 µl ... Western blot analysis of ABCA3 expression in HeLa whole cell lysate. Download ...
http://www.scbt.com/datasheet-48444-abca3-n-20-antibody.html...
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ABC Antibody / ABC Antibodies
ABCA3 (C-18) Antibody, sc-48442, goat IgG, C-terminus (h), WB, IP, IF, ELISA, m, r, h. ABCA3 (N-20) Antibody, sc-48444, goat IgG, N-terminus (h), WB, IP, ...
http://www.scbt.com/table-abc.html...
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ABCA3 siRNA (m) sc-60114
Click here for details. suitable control antibody: ABCA3 (N-20): sc-48444; sqRT- PCR Primer also available: ABCA3 (m)-PR: sc-60114, 20 µl ...
http://www.scbt.com/ko/datasheet-60114-abca3-sirna-m.html...
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ABC Antibody / ABC Antibodies
ABCA3 (C-18) 抗体, sc-48442, goat IgG, C-terminus (h), WB, IP, IF, ELISA, m, r, h .... ABCA3 (3C9) 抗体, sc-58220, mouse IgG2a, FL (r), discontinued, m, r ...
http://www.scbt.com/ja/table-abc.html...
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