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ALAS1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 11929042 |
REVIEW:active site and mechanistic analysis, protein folding, structure and function. |
| 11929048 |
REVIEW: mechanisms involving ALAS deficiency, point mutations, post translational processing, and complex formation with succinyl CoA synthetase subunit B in the pathogenesis of hereditary sideroblastic anemia. |
| 15547665 |
in the liver of Acute liver failure patients, there may be an increase in free heme concentration which down-regulating ALAS1 gene expression |
| 15123725 |
ALAS gene expression is regulated by Hepatic nuclear factor 3 and nuclear factor 1 |
| 12433930 |
ALAS expression is regulated by AP-1 complex through sequestration of cAMP-response element protein (CRE)-binding protein (CBP) coactivator in human cells |
| 15797241 |
5-aminolevulinate synthase gene repression by the potent tumor promoter, TPA, involves multiple signal transduction pathways |
| 15477213 |
First described frameshift ALAS2 mutation, CD506-507 (-C). |
| 15710391 |
Alternative splicing of human ALAS1 generates two mRNAs with different 5'-UTRs: a major one, where exon 1B is omitted, and a minor form containing exon 1B. |
Recent Publications on ALAS1: |  |
Identification of suitable reference genes for gene expression studies of human serous ovarian cancer by real-time polymerase chain reaction.
Quantitative real-time RT-PCR (RT-qPCR) has proven to be a valuable... | 3rd November, 2009
| Women's Reproductive Health Laboratory of Zhejiang Province, Women's
| Anal Biochem. 2009 Nov 1;394(1):110-6. Epub 2009 Jul 19.
DOI Direct Link |
Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease.
Heme is an essential cell metabolite, intracellular regulatory molecule,... | 3rd September, 2009
| Research Service, Department of Veterans Affairs Medical Center, White
| Neurosci Lett. 2009 Aug 28;460(2):180-4. Epub 2009 May 27.
DOI Direct Link |
Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human.
BACKGROUND: Studies in mice have shown that PPARalpha is an important... | 28th August, 2009
| Nutrigenomics Consortium, Top Institute (TI) Food and Nutrition,
| PLoS One. 2009 Aug 27;4(8):e6796.
DOI Direct Link |
Endurance exercise induces mRNA expression of oxidative enzymes in human skeletal muscle late in recovery.
Exercise-induced adaptations in skeletal muscle oxidative enzymes are... | 27th August, 2009
| Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen,
| Scand J Med Sci Sports. 2009 Aug 23.
DOI Direct Link |
Functional analysis of the 5' regulatory region of the 5-aminolevulinate synthase (ALAS1) gene in response to estrogen.
Genetic defects in the heme synthesis enzymes lead to a group of... | 7th August, 2009
| Department of Genetics, Stellenbosch University, Stellenbosch, South
| Cell Mol Biol (Noisy-le-grand). 2009 Jul 1;55(2):20-30.
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→View more research publications. |
ALAS1 results (if any) from reagent suppliers | 
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Alas1 antibody (ab22153) | Abcam
Rabbit polyclonal to Alas1. Delta aminolevulinate synthase catalyzes the condensation of glycine with succinyl CoA to form delta aminolevulinic acid.
http://www.abcam.com/Alas1-antibody-ab22153.html...
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ALAS1 Antibody (C-term)
Western blot analysis of ALAS1 antibody (C-term) (Cat.#AP7486b) in Ramos cell line lysates (35ug/lane). ALAS1 (arrow) was detected using the purified Pab. ...
http://www.abgent.com/products/catalog_no/AP7486b_ALAS1_Anti...
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Alas1 antibodies: Cardiovascular > Blood > Other | Abcam
Alas1 antibodies. ... Alas1 antibodies. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication. ab22153 · Alas1 antibody ...
http://www.abcam.com/index.html?t=115818&pt=1&c=490&ei=&mu=r...
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Abgent - Cell and Function Antibodies
AP7486bNEW, ALAS1 Antibody (C-term), WB, E, H. AT1105a, ALAS1 monoclonal antibody (M01) ... AT1106a, ALAS1 monoclonal antibody (M03), ELISA,WB-Ce,WB-Re,
H ...
http://www.abgent.com/products/category/cell_function...
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ALAS-H (H-154) Antibody sc-50531
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ALAS1, 211, 3p21.1, NM_000688, ...
http://www.scbt.com/datasheet-50531-alas-h-h-154-antibody.ht...
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Abgent - Metabolism Antibodies - Metabolism
AP2735b, AKR1B1 Antibody (C-term), WB, IHC, E, H. AP2735c, AKR1B1 Antibody ( Center), WB, IHC, E, H. AP7486bNEW, ALAS1 Antibody (C-term), WB, E, H ...
http://www.abgent.com/products/category/cell_function/metabo...
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ELISA Confirmed - Antibodies available - Antibodies | Imgenex
IMX-5266, Aminolevulinate delta-synthase 1 (ALAS-1), Sera, H, N/A, Peptide ELISA *, 0.1 mL, N/A, View MSDS. IMX-5269, Aminolevulinate delta-synthase 1 ...
http://www.imgenex.com/elisa_positive.php...
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