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EVI1


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Symbol:EVI1
Name(s):ecotropic viral integration site 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:AML1-EVI-1, EVI-1, MDS1-EVI1, MGC163392, PRDM3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18181178 EVI1 and MDS1/EVI1 overexpression is associated with acute myeloid leukemia
17894555 Inhibition of C/EBPalpha function may be causatively related to the leukemogenic potential of RUNX1/EVI1 chimeric transcription factor.
17693189 High EVI1 expression is associated with acute myeloid leukemias
17693194 In conclusion, the combined MDS-EVI1/EVI1 gene may serve as an alternative MRD marker in AML, especially in samples where other specific markers are lacking.
17635584 ubiquitously-expressed transcript suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like Evi1
17507183 review of EVI1 expression, biochemical properties, and biological functions [review]
17243162 Overexpressed in Fanconi anemia-derived acute myeloid leukemia.
16014322 The general expression patterns of the EVI1 5'-end variants in a panel of 20 human tissues were similar, while pronounced differences were noted in response to all-trans retinoic acid.
12393383 study investigated which of the 2 gene products, AMLEVI1 or MDS1-EVI1, is involved in acute myeloid leukemia transformation and found that AMLEVI1 and not MDS1-EVI1 expression was associated with unfavorable karyotypes
11922610 Data indicate that EVI1 is involved in megakaryocytic differentiation, and the dysmegakaryocytopoiesis in 3q21q26 syndrome could be partly due to an enhanced differentiation of leukemia cells and/or megakaryocytes by constitutive expression of EVI1.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCREB binding proteinEcotropic viral integration site1--Pubmed
HPRDC-terminal binding protein 1 isoform 1ecotropic viral integration site 1--Pubmed
HPRDC-terminal binding protein 2 isoform 2Ecotropic viral integration site1--Pubmed
HPRDEcotropic viral integration site1p300/CBP-associated factor--Pubmed
HPRDEcotropic viral integration site1histone deacetylase 1--Pubmed
HPRDEcotropic viral integration site1histone deacetylase 4--Pubmed
HPRDecotropic viral integration site 1mothers against decapentaplegic homolog 3--Pubmed

Recent Publications on EVI1:

Pubmed Logo
Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.
Translocations resulting in ectopic expression of the TLX1 homeobox gene...
29th October, 2009
Department of Anatomy and Regenerative Biology, The George Washington Genes Chromosomes Cancer. 2009 Oct 27.
DOI Direct Link
[Classification of myeloid leukemias]
Myeloid leukemia in this series corresponds to the myeloid neoplasms of...
29th October, 2009
Hematoimmunology, School of Health Science, Faculty of Medicine, Nippon Rinsho. 2009 Oct;67(10):1853-62.
Zinc finger transcription factor ecotropic viral integration site 1 is induced by all-trans retinoic acid (ATRA) and acts as a dual modulator of the ATRA response.
Ecotropic viral integration site 1 (EVI1) plays important roles in...
22nd October, 2009
Department of Medical Genetics, Medical University of Vienna, Austria. FEBS J. 2009 Oct 16.
DOI Direct Link
Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes.
The oncogene EVI1 has been implicated in the etiology of AML and MDS....
21st October, 2009
Department of Medical Genetics, Medical University of Vienna, A-1090 J Leukoc Biol. 2009 Oct;86(4):813-22. Epub 2009 Jul 15.
DOI Direct Link
Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas.
BACKGROUND: Chemotherapy resistance remains a major obstacle in the...
20th October, 2009
Department of Oncology, Institute of Clinical Sciences, University of BMC Cancer. 2009 Oct 18;9:368.
DOI Direct Link

View more research publications.

BioNews Results for EVI1

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Evil gene may cause hearing impairment
The News International:  Oct 27 2009 11:23PM Matching: evi1

Patents:

Patents logo
US Patent No.Title
7598224 Dual chain synthetic heparin-binding growth factor analogs
7094886 Evi27 gene sequences and protein encoded thereby
6955905 PR/SET-domain containing nucleic acids, polypeptides, antibodies and methods of use
6586579 PR-domain containing nucleic acids, polypeptides, antibodies and methods
6468985 Retinoblastoma protein-interacting zinc finger proteins

View more patents.

EVI1 results (if any) from reagent suppliers

Google CSE Logo
EVI1 antibody (ab28457) | Abcam
Rabbit polyclonal to EVI1. EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity.
http://www.abcam.com/EVI1-antibody-ab28457.html...

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Evi-1 Antibody #2265
Western blot analysis of total cell extracts from MDA-MB231 and SK-OV-3 cells, using Evi-1 antibody. MDS/Evi-1 denotes the fusion between MDS1 and Evi-1 ...
http://www.cellsignal.com/products/2265.html...

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Evi-1 (2331C1a1) Antibody sc-130025
Evi-1 (2331C1a1): sc-130025. Western blot analysis of human recombinant ... Western blot analysis of Evi-1 expression in non-transfected: sc-117752 (A) and
...
http://www.scbt.com/datasheet-130025-evi-1-2331c1a1-antibody...

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CCR7 antibody, C-C chemokine receptor type 7 Antibody, Rabbit ...
CCR7 antibody; CCR7; CMKBR7; EBI1; EVI1; BLR2; CD197; C-C chemokine receptor type 7 ... EVI1 (ecotropic viral integration site 1), IgG ...
http://www.genwaybio.com/product_info.php?products_id=10185...

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Evi-1 (h): 293T Lysate sc-177200
Evi-1 (2331C1a1): sc-130025. Western blot analysis of Evi-1 expression in non- transfected: sc-117752 (A) and human Evi-1 transfected: sc-177200 (B) 293T ...
http://www.scbt.com/datasheet-177200-evi-1-h-293t-lysate.htm...

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HMGB1 antibody, HMGB1 (high-mobility group box 1) Antibody, Rabbit ...
ETV6 (ets variant gene 6 (TEL oncogene)), EVI1 (ecotropic viral integration site 1... EVI1 (ecotropic viral integration site 1. ...
http://www.genwaybio.com/product_info.php?products_id=42680...

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Evi-1 Antibody / Evi-1 Antibodies
Evi-1 Antibody / Evi-1 Antibodies. ... Evi-1 specific siRNA, sHRNA Plasmid과 shRNA Lentiviral Particles gene silencers 도 제공합니다. ...
http://www.scbt.com/ko/table-evi-1.html...

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