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ALCAM


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Symbol:ALCAM
Name(s):activated leukocyte cell adhesion molecule
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD166, FLJ38514, MEMD, MGC71733
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18279810 Over the past decade, alterations in expression of ALCAM have been reported in several human tumors (melanoma, prostate cancer, breast cancer, colorectal carcinoma, bladder cancer, and esophageal squamous cell carcinoma).
18202807 This study has, for the first time, shown that patients who develop skeletal metastasis tend to have the lowest levels of ALCAM transcripts in their breast cancers.
18157132 These findings indicate an important function for ALCAM in the recruitment of leukocytes into the brain.
18171982 disruption of ALCAM-mediated adhesion is a relevant step in ovarian cancer cell motility, and ADAM17/TACE takes part in this process, which may be relevant to invasive potential
17971418 These results indicate that homotypic and heterotypic ALCAM-mediated adhesion are governed by significantly distinct kinetic and mechanical properties.
17624664 HLA-A *0201 restricted ALCAM peptides primed autologous CD8(+) T cells to elicit cytotoxic response against ALCAM(+) human cancer cells.
16204050 Data attribute a novel signaling role to ALCAM in regulation of proteolysis and support its previously postulated sensor function in invasive growth.
15140234 the intact cell adhesion function of ALCAM may both favor primary tumor growth and represent a rate-limiting step for tissue invasion from vertical growth phase melanoma.
15169840 PKCA has a major role in cytoskeleton-dependent avidity modulation of ALCAM.
12481253 ALCAM expression up-regulated in low-grade prostate tumors and down-regulated in high-grade tumors; may play role in progression of prostate cancer

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDactivated leukocyte cell adhesion moleculeactivated leukocyte cell adhesion molecule--Pubmed
HPRDactivated leukocyte cell adhesion moleculeCD6 molecule--Pubmed
HPRDactivated leukocyte cell adhesion moleculeCD6 molecule--Pubmed

Recent Publications on ALCAM:

Pubmed Logo
Phenotypic characterization of distinct human bone marrow-derived MSC subsets.
Very recently, we identified two distinct mesenchymal stem cell (MSC)...
24th October, 2009
University Clinic of Tubingen, Department of Internal Medicine II, Ann N Y Acad Sci. 2009 Sep;1176:124-34.
DOI Direct Link
Cancer vaccine with mimotopes of tumor-associated carbohydrate antigens.
The GD2 ganglioside, displayed by five carbohydrate...
19th September, 2009
Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Immunol Res. 2009 Sep 10.
DOI Direct Link
Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer.
CD133, CD44, and CD166 are cell surface markers that have recently been...
18th September, 2009
Pathologisches Institut, Ludwig-Maximilians-Universitat Munchen, Germany. Cancer Invest. 2009 Oct;27(8):844-50.
DOI Direct Link
Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis.
Fumagillin is an inhibitor of type 2 methionine aminopeptidase that can...
10th September, 2009
Department of Pathology and Biodefense, Faculty of Medicine, Saga Pathol Int. 2009 Jul;59(7):448-61.
DOI Direct Link
Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse.
BACKGROUND: ALCAM (activated leucocyte cell adhesion molecule, synonym...
12th August, 2009
Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Br J Cancer. 2009 Aug 4;101(3):457-64. Epub 2009 Jul 14.
DOI Direct Link

View more research publications.

BioNews Results for ALCAM

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Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs
Nature Reviews Microbiology:  Oct 16 2009 8:30AM Matching: alcam

Patents:

Patents logo
US Patent No.Title
6294663 Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
6936417 Gene expression in bladder tumors
6942978 Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
6955811 Methods of inhibiting immune response suppression by administering antibodies to OX-2
6984625 Methods and compositions for modulating autoimmunity

View more patents.

ALCAM results (if any) from reagent suppliers

Google CSE Logo
ALCAM Antibody / ALCAM Antibodies
ALCAM Antibody / ALCAM Antibodies. ... ALCAM specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-alcam.html...

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Mouse ALCAM Affinity Purified Polyclonal Ab
Mouse ALCAM specific IgG was purified by mouse ALCAM affinity ... This antibody has been selected for its ability to recognize mouse ALCAM in ...
http://www.rndsystems.com/pdf/AF1172.pdf...

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ALCAM Antibody / ALCAM Antibodies
ALCAM (6A66) Antikörper, sc-70345, mouse IgG1, FL (r), IP, IF, h, r ... ALCAM spezifische siRNA, sHRNA Plasmide und shRNA Lentivirale Partikel Gen Silencer
...
http://www.scbt.com/de/table-alcam.html...

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Mouse ALCAM Biotinylated Affinity Purified PAb
31 Mar 2004 ... Mouse ALCAM specific IgG was purified by mouse ALCAM affinity ... appropriate secondary reagents to detect mouse ALCAM. The detection limit ...
http://www.rndsystems.com/pdf/BAF1172.pdf...

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ALCAM (N-21) Antibody sc-8548
See how others have used ALCAM (N-21): sc-8548 antibody and or ALCAM (N-21) ... MEMD/ALCAM: a potential marker for tumor invasion and nodal metastasis in ...
http://www.scbt.com/datasheet-8548-alcam-n-21-antibody.html...

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Monoclonal Anti-human ALCAM (CD166)-Phycoerythrin
It has been suggested that ALCAM-CD6 interactions are important for T cell development and regulation of T cell function (1, 2). ...
http://www.rndsystems.com/pdf/fab6561p.pdf...

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ALCAM (YY5) Antibody sc-73697
mouse monoclonal IgG1, 100µg/ml; raised against the extracellular domain of ALCAM of human origin; recommended for detection of ALCAM of human origin by WB;
...
http://www.scbt.com/datasheet-73697-alcam-yy5-antibody.html...

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