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F2R
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17347481 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17883592 |
Platelet PAR-1/PAR-4 stimulation causes rapid Akt phosphorylation downstream of PLC, whereas with continuous stimulation, ADP and PI3K are required for maintaining Akt phosphorylation. |
| 17848177 |
PAR1 localization in the caveolin-enriched membrane microdomain, bound to caveolin-1, represents a crucial requirement for TF induction in endothelial cells. |
| 17935246 |
Protease activated receptor 1 gene polymorphism is associated with preterm deliveries |
| 17823308 |
when EPCR is bound by protein C, the PAR-1 cleavage-dependent protective signaling responses in endothelial cells can be mediated by either thrombin or APC. |
| 17895623 |
Hypothesis that statins increase risk of hemorrhagic stroke by inhibiting PAR1 receptor is plausible but requires further direct testing in randomized trials. |
| 17623652 |
trypsin IV and p23 are inhibitor-resistant trypsins that can cleave and activate PARs, causing PAR(1)- and PAR(2)-dependent inflammation and PAR(2)-dependent hyperalgesia. |
| 17721620 |
Platelet stimulation with thrombin induces a time- and concentration-dependent regulation of the microtubular content |
| 17492768 |
Activation of PAR1-induced dynamic cytoskeletal reorganization and reduced PC-3 binding to collagen I, collagen IV, and laminin (P < 0.01) but not fibronectin. |
| 17675516 |
P. gingivalis, therefore, selectively up-regulated CCR5 by two independent signaling pathways, Rgp acting on PAR-1 and PAR-2, and LPS on TLR2 and TLR4. | →View more information from publications. |
Recent Publications on F2R: |  |
Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells.
Curcumin, a natural product isolated from the plant Curcuma longa, has a... | 24th September, 2009
| Laboratoire de Biologie Moleculaire et Cellulaire du Cancer, Hopital
| Ann N Y Acad Sci. 2009 Aug;1171:436-47.
DOI Direct Link |
Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study.
BACKGROUND/OBJECTIVES: Age-related changes in blood coagulation and... | 26th June, 2009
| Department of Epidemiology, University of Washington, Seattle, WA 98195,
| J Thromb Haemost. 2009 Sep;7(9):1499-505. Epub 2009 Jun 22.
DOI Direct Link |
Variants in the coagulation factor 2 receptor (F2R) gene influence the risk of myocardial infarction in men through an interaction with interleukin 6 serum levels.
Thrombin-activated factor 2 receptor (F2R) links thrombosis to... | 20th June, 2009
| Division of Cardiovascular Epidemiology, IMM, Karolinska Institute, 17 177
| Thromb Haemost. 2009 May;101(5):943-53.
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Gene expression profiling in TWIST-depleted gastric cancer cells.
TWIST is an important transcription factor during embryonic development... | 15th April, 2009
| The Pathology Department, Affiliated Tumor Hospital of Harbin Medical
| Anat Rec (Hoboken). 2009 Feb;292(2):262-70.
DOI Direct Link |
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin.
BACKGROUND: Preterm labour occurs in approximately 10% of pregnancies and... | 10th April, 2009
| National Centre for Biomedical and Engineering Science, National
| Reprod Biol Endocrinol. 2009 Jan 8;7:2.
DOI Direct Link |
→View more research publications. |
F2R results (if any) from reagent suppliers | 
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CKOZFN1127 CompoZr™ Knockout ZFN Kit human F2R (NM_001992)
CKOZFN1127 CompoZr Knockout ZFN Kit human F2R (NM_001992) CompoZr Knockout ZFNs create targeted double strand breaks at a gene specific target locus.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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Thrombin R (C-18) Antibody sc-8202
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, F2R, 2149, 5q13.3, NM_001992 ...
http://www.scbt.com/datasheet-8202-thrombin-r-c-18-antibody....
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CompoZr™ Knockout ZFN Kits
CKOZFN1127, CompoZr™ Knockout ZFN Kit human F2R (NM_001992) New, human ... F2R( 2149), pricing. CKOZFN1128, CompoZr™ Knockout ZFN Kit human F2R (NM_001992) ...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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Thrombin R (S-19) Antibody sc-8204
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, F2r, 14062, 13 D1, P30558 ...
http://www.scbt.com/datasheet-8204-thrombin-r-s-19-antibody....
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Search Results
Stock# - 002862 Strain name - B6.129S4-F2r/J JAX® Mice Database Site Section: JAX® Mice and services · jaxmice.jax.org/strain/002862.html - 45Kb ...
http://www.jax.org/search/Main.jsp?sg=4&qt=retardation&page=...
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JAK-STAT Signaling Pathway
ALK · F2R (Par1), KDR (CD309). AXL (UFO), F2RL2 · KIT (CD117). BTK · FGFR1 ( CD331), MERTK · CD2 · FGFR2 (CD332), MET · CD4 · FGFR3 (CD333), MST1R (CD136)
...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...
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