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F2RL1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18028876 |
The activation of PAR-2 expressed by human intestinal epithelial cells enhances mucin secretion, a component of the intestinal innate defence, via a pathway involving EGFR transactivation. |
| 18047634 |
Indicate that trypsin-induced cytokine release by endothelial cells is most likely through activation of PAR-2. |
| 17699557 |
Proximal tubule cells are the main site of PAR-2 expression in the human kidney. Trypsinogen expressed within the kidney has the potential to contribute to PAR-2 activation in certain circumstances. |
| 17845211 |
PAR(2) may be involved in the pathophysiology of neutrophil-endothelial interactions during wound healing or later during sepsis, potentially by affecting neutrophil apoptosis, transendothelial migration and Fcgamma receptor-mediated phagocytosis. |
| 16925462 |
PAR-2 is expressed by high levels in infiltrative ductal breast cancer tissue specimens. Activation of PAR-2 influences proliferative and metabolic activity of a breast cancer cell line. |
| 17693410 |
p24A is a regulator of signal-dependent trafficking that controls ARF1-dependent resensitization of PAR-2 |
| 17623652 |
trypsin IV and p23 are inhibitor-resistant trypsins that can cleave and activate PARs, causing PAR(1)- and PAR(2)-dependent inflammation and PAR(2)-dependent hyperalgesia. |
| 17675298 |
HRS mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor |
| 17581194 |
PAR-2 plays a role in serine protease-mediated regulation of IL-8 and GRO-alpha in nasal epithelial cells and may be involved in the pathophysiology of rhinosinusitis. |
| 17591792 |
Gingival epithelial cells utilize PAR-2 to mediate gene expression of beta-defensin 2 (BD-2) and CC chemokine ligand 20 (CCL20) in response to proteases secreted by Porphyromonas gingivalis. | →View more information from publications. |
Recent Publications on F2RL1: |  |
Protease activated receptor signaling is required for african trypanosome traversal of human brain microvascular endothelial cells.
BACKGROUND: Using human brain microvascular endothelial cells (HBMECs) as... | 22nd July, 2009
| Department of Pediatrics, The Johns Hopkins University School of Medicine,
| PLoS Negl Trop Dis. 2009 Jul 21;3(7):e479.
DOI Direct Link |
[Influence of mutations of proteinase-activated receptors F2R/PAR1 and F2RL1/PAR2 on inflammatory bowel disease.]
BACKGROUND AND OBJECTIVE: Inflammatory bowel disease (IBD) is a polygenic... | 21st February, 2009
| Servicio de Inmunologia Clinica, Hospital Clinico San Carlos, Madrid,
| Med Clin (Barc). 2008 Nov 8;131(16):609-11.
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Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labor.
As thrombin is proposed to be involved in stimulating myometrial... | 26th March, 2008
| National Center for Biomedical and Engineering Science, National
| Biol Reprod. 2008 Jan;78(1):20-6. Epub 2007 Sep 26.
DOI Direct Link |
Up-regulation and activation of proteinase-activated receptor 2 in early and delayed radiation injury in the rat intestine: influence of biological activators of proteinase-activated receptor 2.
Proteinase-activated receptor 2 (Par2, F2rl1, also designated PAR-2 or... | 9th January, 2004
| Department of Surgery, University of Arkansas for Medical Sciences and
| Radiat Res. 2003 Nov;160(5):524-35.
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F2RL1 results (if any) from reagent suppliers | 
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PAR-2 (SAM11) Antibody sc-13504
CHROMOSOMAL LOCATION, Genetic locus: F2RL1 (human) mapping to 5q13; F2rl1 (mouse ) mapping to 13 D1.. SOURCE, PAR-2 (SAM11) is a mouse monoclonal antibody ...
http://www.scbt.com/datasheet-13504-par-2-sam11-antibody.htm...
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Anti-Proteinase-activated receptor-2
4 Mar 2008 ... (PAR-2, Thrombin receptor-like1, F2RL1). Product #: APR-032. Current Lot #: AN- 01. Host: Rabbit. Type: Polyclonal. ...
http://www.alomone.com/System/UpLoadFiles/DGallery/Docs/APR-...
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PAR-2 (C-17) Antibody sc-8205
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, F2RL1, 2150, 5q13.3, NM_005242 ...
http://www.scbt.com/datasheet-8205-par-2-c-17-antibody.html...
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Anti-Proteinase-Activated Receptor 2 (P8747) - Data Sheet
Like 1 (F2RL1), is known to play a critical role in acute and chronic inflammation. PAR2 expression is substantially upregulated in inflamed tissues
of the ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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PAR-2 (SAM11) Antibody sc-13504
Chromosomaler Locus, Genetic locus: F2RL1 (human) mapping to 5q13; F2rl1 (mouse) mapping to 13 D1.. WIRTSSPEZIES, PAR-2 (SAM11) is a mouse monoclonal ...
http://www.scbt.com/de/datasheet-13504-par-2-sam11-antibody....
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Cell-Based GPCR Reporter Assays
Protease Activated, F2RL1, PDF Download · K1830, X. P2Y (Purinergic/ Pyrimidinergic), P2RY2, PDF Download · K1722 · K1337, X, Ca²+(Fluo-4) ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...
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PAR-2 (SAM11) Antibody sc-13504
染色体の位置, Genetic locus: F2RL1 (human) mapping to 5q13; F2rl1 (mouse) mapping to 13 D1.. SOURCE, PAR-2 (SAM11) is a mouse monoclonal antibody epitope
...
http://www.scbt.com/ja/datasheet-13504-par-2-sam11-antibody....
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