Tuesday November 24 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

F2RL2


Suggest Content
Advertise Here
Gene DB Home
Symbol:F2RL2
Name(s):coagulation factor II (thrombin) receptor-like 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:PAR3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15582715 PAR3 receptors and analogues can mediate cell signaling by interaction with PAR1-type thrombin receptors
15850610 a Na-independent Cl-/HCO3- exchange mechanism mediates the recovery of pHi from alkalosis in platelets and that thrombin activates this exchanger by a direct regulatory pathway
14507634 findings support a role for PAR1, and potentially PAR2 and PAR3 in the invasive phase of human placentation
12805069 differentiation of human monocytes is associated with differential expression of functionally active PARs that mediate distinct regulatory functions in inflammation and atherogenesis.
16046705 The changes in levels of blood coagulation factor ii in folic acid deficient rats are reversed by treatment with folic acid.
17347481 F2R genetic variants may influence the natural history of CHD in patients at high risk of cardiovascular events.
15504554 expression of PAR3 mRNA and protein in cells undergoing megakaryocytic maturation suggests a developmental role for PAR3; regulation of PAR3 expression appears to be specifically coupled to the protein kinase C system.
17376866 PAR3 has a role in allosterically regulating PAR1 signaling governing increased endothelial permeability
14515192 PAR-3 is expressed in human SMC and triggers intracellular calcium signaling.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCathepsin Gcoagulation factor II receptor-like 2 precursor--Pubmed
HPRDcathepsin G preproproteinProteinase activated receptor 3--Pubmed
HPRDepithelial cell transforming sequence 2 oncogene proteinProteinase activated receptor 3--Pubmed
HPRDcoagulation factor II preproproteincoagulation factor II receptor-like 2 precursor--Pubmed
HPRDProteinase activated receptor 3junctional adhesion molecule 2 precursor--Pubmed
HPRDProteinase activated receptor 3junctional adhesion molecule 3 precursor--Pubmed
HPRDcoagulation factor II receptor-like 2 precursorJunctional adhesion molecule 2--Pubmed
HPRDcoagulation factor II receptor-like 2 precursorJunctional adhesion molecule 3--Pubmed

Recent Publications on F2RL2:

Pubmed Logo
Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labor.
As thrombin is proposed to be involved in stimulating myometrial...
26th March, 2008
National Center for Biomedical and Engineering Science, National Biol Reprod. 2008 Jan;78(1):20-6. Epub 2007 Sep 26.
DOI Direct Link
Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure.
BACKGROUND: Epidemiology studies have linked exposure to pollutant...
23rd May, 2007
National Health and Environmental Effects Research Laboratory, Office of Environ Health Perspect. 2007 Apr;115(4):535-40. Epub 2007 Jan 8.
DOI Direct Link

Patents:

Patents logo
US Patent No.Title
7485468 Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
6706867 DNA array sequence selection

F2RL2 results (if any) from reagent suppliers

Google CSE Logo
PAR-3 (H-103) Antibody sc-5598
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, F2RL2, 2151, 5q13.3, NM_004101 ...
http://www.scbt.com/datasheet-5598-par-3-h-103-antibody.html...

Thumbshot
JAK-STAT Signaling Pathway
ALK · F2R (Par1), KDR (CD309). AXL (UFO), F2RL2 · KIT (CD117). BTK · FGFR1 ( CD331), MERTK · CD2 · FGFR2 (CD332), MET · CD4 · FGFR3 (CD333), MST1R (CD136)
...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

Thumbshot
PAR-3 (H-103) Antibody sc-5598
Humano, F2RL2, 2151, 5q13.3, NM_004101 · O00254 · 601919. camundongo, F2rl2, 14064, 13 D1, O08675, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-5598-par-3-h-103-antibody.h...

Thumbshot

Search Bioportfolio and other Life Science Sites for F2RL2, or search for F2RL2 on BioPortfolio's antibody search engine.
This page has been viewed 132 times
Recent Search Terms used to find this page:
F2RL2 antibody | Homo sapiens coagulation factor II (thrombin) receptor-like 2 (F2RL2), mRNA. | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.