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F8


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Symbol:F8
Name(s):coagulation factor VIII, procoagulant component (hemophilia A)
Type:protein-coding
Organism:Homo sapiens
Synonyms:AHF, DXS1253E, F8 protein, F8B, F8C, FVIII, HEMA
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18217193 Observational study of gene-disease association. (HuGE Navigator)
18162457 Increased levels of Factor VIII occurred in the precursors of cardiac myocytes, smooth muscle and endothelial cells in normal and post-ischemic hearts.
18292408 Using FVIII-deficient plasma as a model of reduced thrombin generation, we demonstrate that low antithrombin levels enhance in vitro hemostatic responses to rFVIIa.
17610549 we have found that F8 gene large deletions are likely to be a high risk factor also for immunetolerance therapy unresponsiveness, while no clear evidence has been demonstrated for other mutation types.
11027931 Observational study of gene-disease association. (HuGE Navigator)
11057857 Observational study of genotype prevalence. (HuGE Navigator)
11091190 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
11122386 Observational study of genetic testing. (HuGE Navigator)
11128113 Observational study of genotype prevalence and genetic testing. (HuGE Navigator)
11391716 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCalreticulincoagulation factor VIII isoform a precursor--Pubmed
HPRDcalreticulin precursorCoagulation factor VIII--Pubmed
HPRDCalnexincoagulation factor VIII isoform a precursor--Pubmed
HPRDcalnexin precursorCoagulation factor VIII--Pubmed
HPRDCoagulation factor VIIIcoagulation factor IX--Pubmed
HPRDCoagulation factor VIIIcoagulation factor X preproprotein--Pubmed
HPRDCoagulation factor VIIIvon Willebrand factor precursor--Pubmed
HPRDCoagulation factor VIIIlectin, mannose-binding, 1 precursor--Pubmed
HPRDCoagulation factor VIIIphytanoyl-CoA 2-hydroxylase isoform a precursor--Pubmed
HPRDcoagulation factor VIII isoform a precursorProtein C--Pubmed

Recent Publications on F8:

Pubmed Logo
A ferric chloride induced arterial injury model used as haemostatic effect model.
Summary. A number of experimental bleeding models have been applied to...
3rd November, 2009
Haemostasis Pharmacology, Biopharmaceuticals Research Unit, Novo Nordisk Haemophilia. 2009 Oct 30.
DOI Direct Link
[Genomic instability in sunflower interspecific hybrids]
The expression of genomic instability was studied at the phenotypical...
29th October, 2009
Genetika. 2009 Aug;45(8):1067-77.
Ligand orientation of human neuroglobin obtained from solution NMR and molecular dynamics simulation as compared with X-ray crystallography.
Neuroglobin, a new member of hemoprotein family, can reversibly bind...
24th October, 2009
Department of Chemistry, Renmin University of China, Beijing 100872, J Inorg Biochem. 2009 Sep 26.
DOI Direct Link
Audience Segmentation as a Social-Marketing Tool in Health Promotion: Use of the Risk Perception Attitude Framework in HIV Prevention in Malawi.
Objectives. We sought to determine whether individuals' risk perceptions...
17th October, 2009
Johns Hopkins University. Am J Public Health. 2009 Oct 15.
DOI Direct Link
Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy.
BACKGROUND: The use of anthracycline chemotherapy is limited by the...
13th October, 2009
Paediatric Oncology, Emma Children's Hospital / Academic Medical Center, Cochrane Database Syst Rev. 2009 Oct 7;(4):CD005008.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Study to Establish Bioequivalence of ReFacto AF (BDDrFVIII) With Advate (FLrFVIII) in Hemophilia A

Patents:

Patents logo
US Patent No.Title
7577936 Optimization of conversion of a character coding system
7581491 Machines used for peeling and coring melons and pineapples
7582302 Needle-free administration of FeLV vaccines
7582734 Functional antibodies that specifically bind to the Chemerin receptor
7582806 Genetic loci associated with iron deficiency tolerance in soybean

View more patents.

F8 results (if any) from reagent suppliers

Google CSE Logo
p27 (F-8) Antibody sc-1641
See how others have used p27 (F-8): sc-1641 antibody and or p27 (F-8) antibody ... p27 (F-8): sc-1641. Western blot analysis of p27 expression in MM-142 (A)
...
http://www.scbt.com/datasheet-1641-p27-f-8-antibody.html...

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Von Willebrand Factor antibody [F8/86] (ab778) | Abcam
Mouse monoclonal [F8/86] to Von Willebrand Factor. Von Willebrand Factor (VWF) was previously known as Factor VIII related antigen.
http://www.abcam.com/Von-Willebrand-Factor-antibody-F8-86-ab...

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VE-cadherin (F-8) Antibody sc-9989
See how others have used VE-cadherin (F-8): sc-9989 antibody and or ... VE- cadherin (F-8) PE: sc-9989 PE. Intracellular FCM analysis of fixed and ...
http://www.scbt.com/datasheet-9989-ve-cadherin-f-8-antibody....

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Influenza A Virus Nucleoprotein antibody [IV F8] (ab8261) | Abcam
Mouse monoclonal [IV F8] to Influenza A Virus Nucleoprotein. The nucleoprotein ( NP) of Influenza virus encapsulates the negative strand of the viral RNA and ...
http://www.abcam.com/Influenza-A-Virus-Nucleoprotein-antibod...

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VWF (F8/86) Antibody sc-53466
VWF (F8/86): sc-53466. Western blot analysis of VWF expression in human platelet (A) and HUV-EC-C (B) whole cell lysates. Download ...
http://www.scbt.com/datasheet-53466-vwf-f8-86-antibody.html...

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VEGF antibody [5C3.F8] (ab3109) | Abcam
Mouse monoclonal [5C3.F8] to VEGF. VEGF (Vascular Endothelial Growth Factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which ...
http://www.abcam.com/VEGF-antibody-5C3-F8-ab3109.html...

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VEGF (5C3.F8) Antibody sc-57495
VEGF (5C3.F8) Antibody sc-57495 VEGF (5C3.F8) Antibody sc-57495. ... F8): sc- 57495. Western blot analysis of human recombinant VEGF fusion protein. ...
http://www.scbt.com/datasheet-57495-vegf-5c3-f8-antibody.htm...

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