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F8


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Symbol:F8
Name(s):coagulation factor VIII, procoagulant component (hemophilia A)
Type:protein-coding
Organism:Homo sapiens
Synonyms:AHF, DXS1253E, F8 protein, F8B, F8C, FVIII, HEMA
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18217193 Observational study of gene-disease association. (HuGE Navigator)
18162457 Increased levels of Factor VIII occurred in the precursors of cardiac myocytes, smooth muscle and endothelial cells in normal and post-ischemic hearts.
18292408 Using FVIII-deficient plasma as a model of reduced thrombin generation, we demonstrate that low antithrombin levels enhance in vitro hemostatic responses to rFVIIa.
17610549 we have found that F8 gene large deletions are likely to be a high risk factor also for immunetolerance therapy unresponsiveness, while no clear evidence has been demonstrated for other mutation types.
11027931 Observational study of gene-disease association. (HuGE Navigator)
11057857 Observational study of genotype prevalence. (HuGE Navigator)
11091190 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
11122386 Observational study of genetic testing. (HuGE Navigator)
11128113 Observational study of genotype prevalence and genetic testing. (HuGE Navigator)
11391716 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCalreticulincoagulation factor VIII isoform a precursor--Pubmed
HPRDcalreticulin precursorCoagulation factor VIII--Pubmed
HPRDCalnexincoagulation factor VIII isoform a precursor--Pubmed
HPRDcalnexin precursorCoagulation factor VIII--Pubmed
HPRDCoagulation factor VIIIcoagulation factor IX--Pubmed
HPRDCoagulation factor VIIIcoagulation factor X preproprotein--Pubmed
HPRDCoagulation factor VIIIvon Willebrand factor precursor--Pubmed
HPRDCoagulation factor VIIIlectin, mannose-binding, 1 precursor--Pubmed
HPRDCoagulation factor VIIIphytanoyl-CoA 2-hydroxylase isoform a precursor--Pubmed
HPRDcoagulation factor VIII isoform a precursorProtein C--Pubmed

Recent Publications on F8:

Pubmed Logo
Quantitative trait loci associated with lettuce seed germination under different temperature and light environments.
Temperature and light are primary environmental cues affecting seed...
29th October, 2008
Department of Plant Sciences, California State Polytechnic University Genome. 2008 Nov;51(11):928-47.
DOI Direct Link
Water-Soluble Gold Nanoparticles Protected by Fluorinated Amphiphilic Thiolates.
The preparation and the properties of gold nanoparticles (Au NPs)...
28th October, 2008
J Am Chem Soc. 2008 Oct 25.
DOI Direct Link
[Diagnosis of male anorgasmia]
Anorgasmia (anejaculation without orgasm) is defined as persistent or...
24th October, 2008
Service d'urologie-andrologie, Centre hospitalier regional La Source, Prog Urol. 2008 Feb;18(1 Suppl FMC):F8-10.
Fracture resistance of Class II glass-ionomer cement restorations.
PURPOSE: To investigate in vitro the effect of retentive grooves, GIC type...
23rd October, 2008
Department of Operative Dentistry, University of North of Parana, Brazil. Am J Dent. 2008 Jun;21(3):163-7.
Evaluation of liposomal dose in recombinant factor VIII reconstituted with pegylated liposomes for the treatment of patients with severe haemophilia A.
Patients with haemophilia A treated prophylactically require frequent...
18th October, 2008
Recoly Curacao, Thromb Haemost. 2008 Sep;100(3):429-34.

View more research publications.

Clinical Trials:

Clinical Trials Logo
Study to Establish Bioequivalence of ReFacto AF (BDDrFVIII) With Advate (FLrFVIII) in Hemophilia A
Hemophilia A

Patents:

Patents logo
US Patent No.Title
7425041 Bicycle wheel balanced by spoke connections of different mass
7431921 Interferon beta-like molecules
7431934 Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same
7432420 Squash with improved disease resistance
7433019 Exposure apparatus and device manufacturing method

View more patents.

F8 results (if any) from reagent suppliers

Google CSE Logo
p27 (F-8) Antibody sc-1641
See how others have used p27 (F-8): sc-1641 and or p27 (F-8) antibody conjugates . ... p27 (F-8): sc-1641. Western blot analysis of p27 expression in MM-142 ...
http://www.scbt.com/datasheet-1641-p27-f-8-antibody.html...

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VEGF antibody [5C3.F8] (ab3109) datasheet | Abcam
Mouse monoclonal [5C3.F8] to VEGF. VEGF (Vascular Endothelial Growth Factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which ...
http://www.abcam.com/index.html?datasheet=3109...

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VE-cadherin (F-8) Antibody sc-9989
See how others have used VE-cadherin (F-8): sc-9989 and or VE-cadherin (F-8) ... VE-cadherin (F-8) PE: sc-9989 PE. Intracellular FCM analysis of fixed and ...
http://www.scbt.com/datasheet-9989-ve-cadherin-f-8-antibody....

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Von Willebrand Factor antibody [F8/86], prediluted (ab855 ...
Mouse monoclonal [F8/86] to Von Willebrand Factor, prediluted. Von Willebrand Factor (VWF) was previously known as Factor VIII related antigen.
http://www.abcam.com/index.html?datasheet=855...

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Plk (F-8) Antibody sc-17783
Blot probed with Plk (F-8): sc-17783. β Tubulin (D-10): sc-5274 used as specificity and ... Plk (F-8): sc-17783. Western blot analysis of Plk expression
in ...
http://www.scbt.com/datasheet-17783-plk-f-8-antibody.html...

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CD45RA antibody, CD45RA [F8-11-13] antibody (FITC) Antibody, Mouse ...
Buy quality mouse CD45RA antibody (interacts with human), anti-CD45RA, CD45RA [ F8-11-13] antibody (FITC) antibody, mouse igg monoclonal antibody, ...
http://www.genwaybio.com/product_info.php?products_id=190865...

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ICAD (F-8) Antibody sc-17816
ICAD (F-8): sc-17816. Western blot analysis of ICAD/DFF expression in HeLa (A) and U-937 (B) whole cell lysates. ICAD (F-8): sc-17816. ...
http://www.scbt.com/datasheet-17816-icad-f-8-antibody.html...

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CD45RA antibody [F8-11-13] (ab59168) datasheet | Abcam
Mouse monoclonal [F8-11-13] to CD45RA. CD45 is a complex molecule, and is comprised of different glycoproteins ranging from 180-240 kDa.
http://www.abcam.com/index.html?datasheet=59168...

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Laminin α-1 (F-8) Antibody sc-74417
Laminin α-1 (F-8): sc-74417. Western blot analysis of Laminin α-1 expression in Caki-1 (A) and HeLa (B) whole cell lysates. Download ...
http://www.scbt.com/datasheet-74417-laminin-alpha-1-f-8-anti...

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Influenza A Virus Nucleoprotein antibody [F8] (ab67428) datasheet ...
Mouse monoclonal [F8] to Influenza A Virus Nucleoprotein. The nucleoprotein (NP) of Influenza virus encapsulates the negative strand of the viral RNA and is ...
http://www.abcam.com/index.html?datasheet=67428...

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