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F11
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18186617 |
enzyme activity is impaired in FXIa when Gly193 is replaced by a non-Gly residue, and residues with side chains that branch at the beta-carbon have the greatest effect on catalysis and binding of substrates. |
| 11895778 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16613788 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17284699 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18217146 |
The majority of coronary artery disease patients had circulating FXIa that correlates with markers of coagulation and inflammation. |
| 17581330 |
a novel mutation, a C-to-G transition at position 1394 in exon 12 in the FXI gene (F11 c.1394 C>G). This transition resulted in a missense mutation (Gln433Glu), which led to the disruption of the catalytic domain structure of the FXI molecule. |
| 18024374 |
five FXI missense mutations (four novel) were associated with impaired secretion albeit normal dimerization, underscoring the existence of other mechanisms for defective secretion |
| 17768109 |
ADAMTS13/FXI complexes are insignificant in plasma |
| 17652512 |
activation of FXI by thrombin in solution or on the surface of activated platelets does not appear to play a significant role in a plasma environment |
| 17597996 |
review of the role of FXI in thrombosis and hemostasis, and the etiology and antithrombotic effect of FXI deficiency | →View more information from publications. |
Recent Publications on F11: |  |
Fusion of barnase to antiferritin antibody F11 VH domain results in a partially folded functionally active protein.
A chimeric protein, VH-barnase, was obtained by fusing the VH domain of... | 23rd October, 2009
| Research and Production Center for Hematology and Transfusiology, Ministry
| Biochemistry (Mosc). 2009 Jun;74(6):672-80.
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Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency.
Factor XI (FXI) functions in blood coagulation. FXI is composed of four... | 22nd October, 2009
| Institute of Structural and Molecular Biology, University College London,
| Thromb Haemost. 2009 Aug;102(2):287-301.
DOI Direct Link |
Long-term outcome of in-patients with substance use disorders: A study from North India.
BACKGROUND: Research into substance use disorders (SUD) has been unable to... | 14th October, 2009
| Department of Psychiatry, Postgraduate Institute of Medical Education and
| Indian J Psychiatry. 2008 Oct;50(4):269-73.
DOI Direct Link |
Development, characterization, and immunotherapeutic use of peptide mimics of the Thomsen-Friedenreich carbohydrate antigen.
The tumor-associated carbohydrate Thomsen-Friedenreich antigen (TF-Ag;... | 10th October, 2009
| Department of Microbiology and Immunology, University at Buffalo, The
| Neoplasia. 2009 Aug;11(8):780-92.
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Bioapplications of RAFT Polymerization.
BACKGROUND: Research into substance use disorders (SUD) has been unable to... | 22nd September, 2009
| Centre for Advanced Macromolecular Design (CAMD), School of Chemical
| Chem Rev. 2009 Sep 18.
DOI Direct Link |
→View more research publications. |
F11 results (if any) from reagent suppliers | 
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