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FABP4


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Gene DB Home
Symbol:FABP4
Name(s):fatty acid binding protein 4, adipocyte
Type:protein-coding
Organism:Homo sapiens
Synonyms:A-FABP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15015141 Observational study of gene-disease association. (HuGE Navigator)
16641093 Observational study of gene-disease association. (HuGE Navigator)
18024526 FABP4 concentrations should be taken into consideration as an early marker of kidney damage in patients with type 2 diabetes.
17553506 thiazolidinedione increases FABP4 plasma concentrations in diabetic patients, reflecting PPARgamma activation
17826730 Hypoxia enhances the expression of FABP4 in term human trophoblasts, suggesting that fatty acid binding proteins support fat accumulation in the hypoxic placenta.
17396233 These data indicate for the first time that human macrophage aP2 promoter is a direct target for the regulation by LXR/RXR heterodimers.
12417276 observations suggest that oxLDL-mediated increase in gene expression accelerate cholesterol ester accumulation, and that this is an important component of the genetic program regulating conversion of macrophages to foam cells
15168018 intra-pair correlations revealed that FATP4 expression was signifcantly up-regulated in acquired obesity.
16641093 Data demonstrate a significant genetic variation in humans that results in decreased adipose tissue aP2 expression due to alteration of the CAAT box/enhancer-binding protein binding and reduced transcriptional activity of the aP2 promoter.
17322100 the metallothionein genes, adipophilin (ADFP), CD36, adipocyte fatty acid binding protein (FABP4), ATP binding cassette protein A1 (ABCA1), and liver X receptor (LXR[alpha]) all emerged as strongly positively correlated with PPAR[gamma] expression.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDacid phosphatase 1 isoform cFatty acid binding protein 4--Pubmed
HPRDFatty acid binding protein 4hormone-sensitive lipase--Pubmed
HPRDfatty acid binding protein 4, adipocyteLipase hormone sensitive--Pubmed

Recent Publications on FABP4:

Pubmed Logo
Correlation between porcine PPARGC1A mRNA expression and its downstream target genes in backfat and longissimus dorsi muscle.
Knowledge of in vivo relationship between the coactivator PPARGC1A and its...
31st October, 2009
Department of Nutrition, Genetics and Ethology, Faculty of Veterinary J Appl Genet. 2009;50(4):361-369.
FABP4: a novel candidate gene for polycystic ovary syndrome.
BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex multifactorial...
22nd October, 2009
Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical Endocrine. 2009 Oct 21.
DOI Direct Link
Ubiquitin Carboxyl-Terminal Hydrolase L3 Promotes Insulin Signaling and Adipogenesis.
Insulin is a potent adipogenic hormone that triggers the induction of a...
20th October, 2009
Department of Degenerative Neurological Diseases, National Institute of Endocrinology. 2009 Oct 16.
DOI Direct Link
The spatial repositioning of adipogenesis genes is correlated with their expression status in a porcine mesenchymal stem cell adipogenesis model system.
Alterations in the nuclear positioning of chromosomes and specific genes...
17th October, 2009
Department of Genetics and Animal Breeding, Poznan University of Life Chromosoma. 2009 Oct;118(5):647-63. Epub 2009 Jul 8.
DOI Direct Link
The Physiologic Effects of Caloric Restriction Are Reflected in the in Vivo Adipocyte-Enriched Proteome of Overweight/Obese Subjects.
We have applied our recently designed proteomics apparoach to search for...
16th October, 2009
NUTRIM School for Nutrition, Toxicology and Metabolism, Department of J Proteome Res. 2009 Oct 27.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
CCRC: Understanding the Effects of Omega-3 Fatty Acids Versus Lignans in Flaxseed on Metabolic and Inflammatory Markers Leading to Diabetes and Cardiovascular Disease

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7135611 Compositions and methods for characterizing and regulating Wnt pathways
7183057 Tape stripping methods for analysis of skin disease and pathological skin state
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

FABP4 results (if any) from reagent suppliers

Google CSE Logo
FABP4 Antibody #2120
Polyclonal antibodies are produced by immunizing rabbits with a synthetic peptide (KLH-coupled) derived from the sequence of mouse FABP4. ...
http://www.cellsignal.com/products/2120.html...

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FABP4 antibody (ab66682) | Abcam
FABP4 encodes the fatty acid binding protein found in adipocytes. ... See below for FABP4 antibody images, references, products related to ab66682 and other ...
http://www.abcam.com/Fatty-Acid-Binding-Protein-4-antibody-a...

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Cayman Chemical | FABP4 Polyclonal Antibody | Description • ALBP ...
7,8 Cayman's FABP4 polyclonal antibody can be used for western blot and immunocytochemical analysis on samples of human, rat, and murine origin. ...
http://www.caymanchem.com/app/template/Product.vm/catalog/10...

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FABP4 antibody (ab13979) | Abcam
FABP4 encodes the fatty acid binding protein found in adipocytes. It is a lipid transport protein and binds both long chain fatty acids and retinoic acid. ...
http://www.abcam.com/FABP4-antibody-ab13979.html...

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FABP4 Antibody
proteins is FABP4, which is also called adipocyte fatty acid ... at the FABP4 locus which results in the reduction of FABP4 expression. ...
http://www.cellsignal.com/pdf/2120.pdf...

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FABP4 antibody [5B5] (ab19724) | Abcam
Mouse monoclonal [5B5] to FABP4. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long chain fatty acids,
...
http://www.abcam.com/FABP4-antibody-5B5-ab19724.html...

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HPA002188 Anti-FABP4 antibody produced in rabbit Prestige ...
HPA002188 Anti-FABP4 antibody produced in rabbit Prestige Antibodies Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=HPA0...

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