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FABP3


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Symbol:FABP3
Name(s):fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
Type:protein-coding
Organism:Homo sapiens
Synonyms:FABP11, H-FABP, MDGI, O-FABP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12872269 Observational study of gene-disease association. (HuGE Navigator)
18159110 persistently high H-FABP levels despite improvement in symptoms and signs of CHF predicted significantly higher cardiac event rates
18021874 FABP3 predicts long-term mortality after ACS and identifies high-risk patients in a manner that is additive to clinical risk factors, troponin, and hs-CRP, possibly identifying myocardial ischemia with or without necrosis.
17721027 high serum H-FABP levels may represent latent cardiac injury and have important clinical implications
17826730 Hypoxia enhances the expression of FABP3 in term human trophoblasts, suggesting that fatty acid binding proteins support fat accumulation in the hypoxic placenta.
17289870 heart-type fatty acid-binding protein affects the response to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor in lung adenocarcinoma
15068254 Decreased heart-type FABP levels may alter lipid composition and/or fluidity in membrane of brains with degeneration, e.g., Down syndrome and Alzheimer's disease.
15459486 A subset of human gastric carcinoma expresses H-FABP and its expression is associated with FAS status, disease progression, tumor aggressiveness and poor patient survival.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDfatty acid binding protein 3TNNI3 interacting kinase isoform b--Pubmed

Recent Publications on FABP3:

Pubmed Logo
Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells.
Supplementation of long-chain polyunsaturated fatty acids (LCPUFAs) is...
3rd November, 2009
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Placenta. 2009 Oct 30.
DOI Direct Link
Qualification of cardiac troponin I concentration in mouse serum using isoproterenol and implementation in pharmacology studies to accelerate drug development.
Cardiac troponin I is a useful biomarker of myocardial injury, but its use...
30th October, 2009
Lilly Research Laboratories, A Division of Eli Lilly and Company, Toxicol Pathol. 2009;37(5):617-28. Epub 2009 Jun 23.
DOI Direct Link
Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats.
Since cardiac and skeletal myotoxicity affect the development of drug...
27th October, 2009
Drug Safety Evaluation, Developmental Research Laboratories, Shionogi & Toxicology. 2009 Oct 22.
DOI Direct Link
Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels.
Heart-type fatty acid-binding protein (H-FABP) is widely distributed and...
20th October, 2009
Research Laboratory of Biochemistry, Basic Medical Institute, Chinese PLA Eur J Pharmacol. 2009 Aug 15;616(1-3):244-50. Epub 2009 Jul 1.
DOI Direct Link
An evaluation of four candidate genes for use in selection programmes aimed at increased intramuscular fat in Duroc swine.
A sufficient level of intramuscular fat (IMF) is needed to enhance...
17th October, 2009
National Swine Registry, West Lafayette, Indiana, USA. J Anim Breed Genet. 2009 Jun;126(3):228-36.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Diagnostic Value of Heart-Fatty Acid Binding Protein and Ischemia Modified Albumin as Biochemical Markers on Non ST Segment Elevation Acute Coronary Syndrome at the Emergency Room.

Patents:

Patents logo
US Patent No.Title
7504225 Reagents and methods for use in cancer diagnosis, classification and therapy
7447594 Molecular cardiotoxicology modeling
7426441 Methods for determining renal toxins
7415358 Molecular toxicology modeling
7251568 Methods and compositions for regulating bone and cartilage formation

View more patents.

FABP3 results (if any) from reagent suppliers

Google CSE Logo
FABP3 antibody, FABP3 (fatty acid binding protein 3. muscle and ...
Buy quality rabbit FABP3 antibody (interacts with human), anti-FABP3, FABP3 ( fatty acid binding protein 3. muscle and heart (mammary-derived growth ...
http://www.genwaybio.com/product_info.php?products_id=42444...

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Cayman Chemical | FABP3 Monoclonal Antibody (Clone CC68 ...
FABP3 is composed of ten antiparallel β strands that form a barrel and is the most widely distributed FABP. It is found in heart, skeletal and smooth muscle
...
http://www.caymanchem.com/app/template/Product.vm/catalog/10...

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FABP3 antibody, HEART FATTY ACID BINDING PROTEIN (H-FABP) Antibody ...
Buy quality mouse igg1 FABP3 antibody (interacts with human), anti-FABP3, HEART FATTY ACID BINDING PROTEIN (H-FABP) antibody, mouse igg1 monoclonal antibody ...
http://www.genwaybio.com/product_info.php?products_id=175100...

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MONOCLONAL ANTIBODY TO HUMAN HEART FATTY ACID BINDING PROTEIN (H ...
The H-FABP protein is derived from the human FABP3 gene. FABPs ... FABP3, Muscle fatty acid-binding protein, Mammary-derived growth inhibitor. Species ...
http://www.hbt.nl/HM2016.pdf...

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Human FABP3 Affinity Purified Polyclonal Ab
was purified by human FABP3 affinity chromatography. Human FABP3, also ... This antibody has been selected for its ability to recognize human FABP3 in ...
http://www.rndsystems.com/pdf/af1678.pdf...

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ELISA KIT FOR HUMAN HEART FATTY ACID BINDING PROTEIN (H-FABP, FABP3)
(H-FABP, FABP3). Catalog no. HK401 (1x 96 determinations). Description ... FABP3 , Muscle fatty acid-binding protein, Mammary-derived growth inhibitor ...
http://www.hbt.nl/Site/Components/FileCP/Download.aspx?id=c9...

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Human FABP3 Biotinylated Affinity Purified PAb
was purified by human FABP3 affinity chromatography and then biotinylated. ... appropriate secondary reagents to detect human FABP3. The detection limit ...
http://www.rndsystems.com/pdf/baf1678.pdf...

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