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FANCA
| Symbol: | FANCA | | Name(s): | Fanconi anemia, complementation group A | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FA, FA-H, FA1, FAA, FACA, FAH, FANCH, MGC75158 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18270339 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 15860134 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15917947 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18056155 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12637330 |
Leukemic cells bearing both characteristic complex cytogenetic defects and marked decrease in nuclear FANCA, were analyzed for possible role of RANCA in cytogenetic instability and clonal progression to AML. |
| 15790592 |
can be actively exported out of the nucleus by CRM1 |
| 15138265 |
FANCA and FANCG uniquely respond to oxidative damage by forming complexes via intermolecular disulfide linkages |
| 15256425 |
FA proteins function at the level of chromatin during S phase to regulate and maintain genomic stability. |
| 12444097 |
Mutant FANCA proteins complement the sensitivity of DNA crosslinker mitomycin C at different grades: five proteins (group I) behave like wild-type FANCA, whereas the other proteins are either mildly (group II, n=4) or severely (group III, n=12) impaired. |
| 15059067 |
2 unique Fanconi-anemia-causing mutations were found: FANCA gross deletion of exons 6-31 & FANCA splice-site mutation IVS 42-2A>C. The gross deletion had recombination between 2 highly homologous Alu elements. The splice mutation had intron 42 retention. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | breast cancer 1, early onset isoform 1 | Fanconi anemia, complementation group A | - | - | Pubmed |
| HPRD | breast cancer 1, early onset isoform 1 | Fanconi anemia, complementation group A | - | - | Pubmed |
| BIND | breast cancer 1, early onset isoform 1 | Fanconi anemia, complementation group A | BRCA1 interacts with FANCA. | - | Pubmed |
| HPRD | Fanconi anemia, complementation group A | Fanconi anemia, complementation group C | - | - | Pubmed |
| HPRD | Fanconi anemia, complementation group A | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | - | - | Pubmed |
| HPRD | Fanconi anemia, complementation group A | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 | - | - | Pubmed |
| HPRD | Fanconi anemia, complementation group A | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin c1 | - | - | Pubmed |
| HPRD | Fanconi anemia, complementation group A | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 isoform 1 | - | - | Pubmed |
| HPRD | Fanconi anemia, complementation group A | Fanconi anemia, complementation group G | - | - | Pubmed |
| HPRD | Fanconi anemia, complementation group A | Fanconi anemia, complementation group E | - | - | Pubmed |
Recent Publications on FANCA: |  |
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction.
Fanconi anemia is a cancer-prone inherited bone marrow failure and cancer... | 29th October, 2009
| Department of Microbiology, University of Virginia Health System,
| Cancer Res. 2009 Oct 27.
DOI Direct Link |
Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766.
Fanconi anemia is a severe bone marrow failure syndrome resulting from... | 14th October, 2009
| Division of Experimental Hematology, Cincinnati Children's Hospital
| Haematologica. 2009 Jul;94(7):1011-5. Epub 2009 Jun 2.
DOI Direct Link |
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.
The Fanconi anemia (FA) molecular network consists of 15 "FANC" proteins,... | 30th September, 2009
| Biology and Biotechnology Division, L452, Lawrence Livermore National
| Mutat Res. 2009 Jul 31;668(1-2):54-72. Epub 2009 Feb 21.
DOI Direct Link |
FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA.
Fanconi anemia (FA) is a rare autosomal recessive or X-linked disorder... | 30th September, 2009
| Division of Experimental Hematology and Cancer Biology, Cincinnati
| Mutat Res. 2009 Jul 31;668(1-2):20-6. Epub 2009 Apr 18.
DOI Direct Link |
Checkpoint signaling from a single DNA interstrand crosslink.
DNA interstrand crosslinks (ICLs) are the most toxic lesions induced by... | 29th September, 2009
| Institute for Cancer Genetics, Department of Genetics and Development,
| Mol Cell. 2009 Sep 11;35(5):704-15.
DOI Direct Link |
→View more research publications. |
FANCA results (if any) from reagent suppliers | 
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Search Bioportfolio and other Life Science Sites for FANCA,
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