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FANCC


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Gene DB Home
Symbol:FANCC
Name(s):Fanconi anemia, complementation group C
Type:protein-coding
Organism:Homo sapiens
Synonyms:FA3, FAC, FACC, FLJ14675
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18264947 Observational study of genotype prevalence. (HuGE Navigator)
11876000 Observational study of genotype prevalence. (HuGE Navigator)
15695377 Observational study of gene-disease association. (HuGE Navigator)
15726604 Observational study of genotype prevalence. (HuGE Navigator)
17977515 We found six differentially expressed proteins; among them, the checkpoint mediator protein MDC1 whose expression was disrupted in FANCC-/- cells.
15299030 Inappropriate activation of Protein kinase regulated by RNA may cause mutations in FANCC>
15256425 FA proteins function at the level of chromatin during S phase to regulate and maintain genomic stability.
15327776 Data show that the Fanconi anemia protein FANCC cooperate with key mutagenesis and repair processes that enable replication of damaged DNA.
15616572 spontaneous SCE levels were elevated approximately 2-fold in cells deficient in Fanconi anemia gene FANCC
12239156 The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of this protein.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCDC2Fanconi anemia, complementation group C--Pubmed
HPRDcell division cycle 2 protein isoform 1Fanconi anemia, complementation group C--Pubmed
HPRDFanconi anemia, complementation group AFanconi anemia, complementation group C--Pubmed
HPRDFanconi anemia, complementation group AFanconi anemia, complementation group C--Pubmed
HPRDFanconi anemia, complementation group Cspectrin, alpha, erythrocytic 1--Pubmed
HPRDFanconi anemia, complementation group CFanconi anemia, complementation group G--Pubmed
HPRDFanconi anemia, complementation group CFanconi anemia, complementation group E--Pubmed
HPRDFanconi anemia, complementation group CFanconi anemia, complementation group F--Pubmed
HPRDFanconi anemia, complementation group CFanconi anemia complementation group D2 isoform a--Pubmed
HPRDFanconi anemia, complementation group CFanconi anemia group G protein--Pubmed

Recent Publications on FANCC:

Pubmed Logo
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction.
Fanconi anemia is a cancer-prone inherited bone marrow failure and cancer...
29th October, 2009
Department of Microbiology, University of Virginia Health System, Cancer Res. 2009 Oct 27.
DOI Direct Link
TLR8-dependent TNF{alpha} over-expression in Fanconi anemia group C cells.
A Fanconi anemia (FA) protein complex facilitates ubiquitinylation of...
24th October, 2009
Department of Biochemistry and Molecular Biology, Oregon Health & Science Blood. 2009 Oct 22.
DOI Direct Link
Validation of Fanconi anemia complementation Group A assignment using molecular analysis.
PURPOSE: Fanconi anemia is a genetically heterogeneous chromosomal...
26th September, 2009
Department of Molecular and Medical Genetics, Clinical Genetics Genet Med. 2009 Mar;11(3):183-92.
DOI Direct Link
Identification and characterization of mutations in FANCL gene: a second case of Fanconi anemia belonging to FA-L complementation group.
Fanconi anemia (FA) is a rare autosomal recessive or X-linked disorder...
24th September, 2009
Experimental Hematology and Cancer Biology, Cincinnati Children's Research Hum Mutat. 2009 Jul;30(7):E761-70.
DOI Direct Link
Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response.
The present study aimed at elucidating mechanisms dictating cell death...
21st July, 2009
Institute of Toxicology, University Medical Center of the Johannes Mutat Res. 2009 Nov 2;670(1-2):32-41. Epub 2009 Jul 16.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7291461 Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay

View more patents.

FANCC results (if any) from reagent suppliers

Google CSE Logo
FANCC antibody (ab5065) | Abcam
Rabbit polyclonal to FANCC. FANCC is a DNA repair protein that may operate in postreplication repair or a cell cycle checkpoint function.
http://www.abcam.com/FANCC-antibody-ab5065.html...

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FANC Antibody / FANC Antibodies
The FA Group C complementation group gene encodes the protein FANCC, ... FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the ...
http://www.scbt.com/table-fanc.html...

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Certificate of Analysis Product: Affinity Purified Anti-FANCF ...
Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG . Hum. Mol. Genet. 9 (18), 2665-2674. Related Products: #600-401-670 ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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FANC Antibody / FANC Antibodies
The FA Group C complementation group gene encodes the protein FANCC, ... Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to
...
http://www.scbt.com/pt/table-fanc.html...

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Page 1 of 2 e-mail: info@rockland-inc.com Visit our website at ...
includes FANCA, FANCB, FANCC, FANCD1 (also called ... Anti-Human FANCC (Rabbit). 600-401-673. Anti-Human FANCE (Rabbit). 200-401-674 ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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FANCC siRNA (m) sc-35355
Click here for details. suitable control antibody: FANCC (C-14): sc-18110; sqRT- PCR Primer also available: FANCC (m)-PR: sc-35355-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-35355-fancc-sirna-m.html...

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ANTIBODY BASED TOOLS
FANCC. 600-401-672. Rb. E, IP, WB. 215/100 ug. FANCF. 600-401-674. Rb. E, IP, WB . 215/100 ug. HR23A (RAD23A). 600-101-291 ...
http://www.rockland-inc.com/commerce/static/NL-RL.pdf...

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