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FANCD2


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Symbol:FANCD2
Name(s):Fanconi anemia, complementation group D2
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp762A223, FA-D2, FA4, FACD, FAD, FAD2, FANCD, FLJ23826
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18270339 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
18029388 Loss of CHK1 function impedes DNA dmage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia.
16679306 Observational study of gene-disease association. (HuGE Navigator)
17898070 Study found that Fanconi anemia pathway activation is triggered mainly by the HPV type 16 (HPV-16) E7 oncoprotein and is associated with an enhanced formation of large FANCD2 foci and recruitment of FANCD2 as well as FANCD1/BRCA2 to chromatin.
17643815 Knocking-down FANCD2 gene expression increases sensitivity of cancer cells to mitomycin C and to less extent to gamma-rays. Cell lines with significant FANCD2 depletion revealed decreased recurrence capacity.
15454491 The carboxy terminus of FANCD2-44 plays a critical role in sensing or repairing DNA damage.
15849361 FANCD2 bound to DNA with specificity for certain structures: double strand DNA ends and Holliday junctions
16943440 These findings support the functional connection of ATM/ATR kinases and FANCD2 in the DNA damage response and support a role for the FA pathway in the coordination of the S phase of the cell cycle.
16679306 FANCD2 single nucleotide polymorphisms may be associated with sporadic breast cancer risk
12649160 Direct interaction between FANCE and FANCD2 involving an amino-terminal region of FANCD2 was demonstrated; this interaction may provide a link between the FA protein complex and its downstream targets.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBRCA1Fanconi anemia complementation group D2 isoform a--Pubmed
HPRDbreast cancer 1, early onset isoform 1Fanconi anemia, complementation group D2--Pubmed
BINDbreast cancer 2, early onsetFanconi anemia complementation group D2 isoform aFANCD2 interacts with BRCA2.-Pubmed
HPRDFanconi anemia, complementation group CFanconi anemia complementation group D2 isoform a--Pubmed
HPRDFanconi anemia, complementation group CFanconi anemia, complementation group D2--Pubmed
HPRDFanconi anemia, complementation group D2RAD51 homolog protein isoform 1--Pubmed
HPRDFanconi anemia, complementation group D2Fanconi anemia, complementation group E--Pubmed
HPRDFanconi anemia complementation group D2 isoform aFanconi anemia protein E--Pubmed
HPRDFanconi anemia complementation group D2 isoform aRAD51--Pubmed
BINDFanconi anemia complementation group D2 isoform aubiquitin specific protease 1USP1 interacts with FANCD2.-Pubmed

Recent Publications on FANCD2:

Pubmed Logo
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction.
Fanconi anemia is a cancer-prone inherited bone marrow failure and cancer...
29th October, 2009
Department of Microbiology, University of Virginia Health System, Cancer Res. 2009 Oct 27.
DOI Direct Link
Involvement of p29 in DNA damage responses and Fanconi anemia pathway.
Human p29 is a chromatin-associated protein and the silencing of p29...
27th October, 2009
Institute of Biochemical Sciences, National Taiwan University, No. 1, Carcinogenesis. 2009 Oct;30(10):1710-6. Epub 2009 Sep 11.
DOI Direct Link
TLR8-dependent TNF{alpha} over-expression in Fanconi anemia group C cells.
A Fanconi anemia (FA) protein complex facilitates ubiquitinylation of...
24th October, 2009
Department of Biochemistry and Molecular Biology, Oregon Health & Science Blood. 2009 Oct 22.
DOI Direct Link
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.
Genomic stability requires a functional Fanconi anemia (FA) pathway...
20th October, 2009
Department of Biochemistry, Oregon Health and Science University, J Biol Chem. 2009 Sep 18;284(38):25560-8. Epub 2009 Jul 24.
DOI Direct Link
XPF-ERCC1 participates in the Fanconi anemia pathway of crosslink repair.
Interstrand crosslinks (ICLs) prevent DNA strand separation, and therefore...
7th October, 2009
Department of Human Genetics, University of Pittsburgh School of Public Mol Cell Biol. 2009 Oct 5.
DOI Direct Link

View more research publications.

BioNews Results for FANCD2

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Two proteins act as molecular tailors in DNA repair
PhysOrg.com:  Nov 13 2009 3:34PM Matching: fancd2

Patents:

Patents logo
US Patent No.Title
7531530 Therapeutic compounds
7108992 ATM kinase compositions and methods
7160692 ATM kinase compositions and methods
7279290 ATM kinase compositions and methods
7291461 Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay

View more patents.

FANCD2 results (if any) from reagent suppliers

Google CSE Logo
FANCD2 antibody [103 ] (ab12450) | Abcam
Mouse monoclonal [103 ] to FANCD2. Fanconi Anemia (FANC) is a human autosomal- recessive cancer susceptibility disorder characterized by congenital defects,
...
http://www.abcam.com/FANCD2-antibody-103-ab12450.html...

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Phospho-FANCD2 (Ser222) Antibody #4945
Western blot analysis of extracts from untreated or UV-treated (50 mJ/cm2, 1hr) ME-180 and HT-29 cells, using Phospho-FANCD2 (Ser222) Antibody. ...
http://www.cellsignal.com/products/4945.html...

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FANCD2 (FI17) Antibody sc-20022
See how others have used FANCD2 (FI17): sc-20022 antibody and or FANCD2 (FI17) ... Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to ...
http://www.scbt.com/datasheet-20022-fancd2-fi17-antibody.htm...

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Phospho-FANCD2 (Ser222) Antibody
phosphorylation of FANCD2 at Ser222 and Ser1404 result- ing in an S-phase arrest (4). ... Antibody detects endogenous levels of FANCD2 only when ...
http://www.cellsignal.com/pdf/4945.pdf...

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FANCD2 antibody [FI-17] - ChIP Grade (ab5360) reviews | Abcam
9 May 2007 ... Mouse monoclonal [FI-17] to FANCD2 - ChIP Grade. Fanconi Anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder ...
http://www.abcam.com/index.html?pageconfig=reviews&intAbID=5...

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FANC Antibody / FANC Antibodies
FANCD2 (FI17) Antibody, sc-20022, mouse IgG1, N-terminus (h), WB, IP, human. FANCD2 (E-19) Antibody, sc-23584, goat IgG, C-terminus (h), WB, IP, IF, human
...
http://www.scbt.com/table-fanc.html...

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FANCD2 antibodies: Chromatin and Nuclear Signaling > DNA / RNA ...
FANCD2 antibodies. ... FANCD2 (phospho S222) antibody. ICC, WB. Rabbit polyclonal ... FANCD2 antibody (Hilyte Fluorâ„¢ 488). IHC-P, WB, ICC/IF, IP ...
http://www.abcam.com/index.html?t=8961&pt=1&c=880&ei=&mu=ra...

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