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FANCD2
| Symbol: | FANCD2 | | Name(s): | Fanconi anemia, complementation group D2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DKFZp762A223, FA-D2, FA4, FACD, FAD, FAD2, FANCD, FLJ23826 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18270339 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 18029388 |
Loss of CHK1 function impedes DNA dmage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia. |
| 16679306 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17898070 |
Study found that Fanconi anemia pathway activation is triggered mainly by the HPV type 16 (HPV-16) E7 oncoprotein and is associated with an enhanced formation of large FANCD2 foci and recruitment of FANCD2 as well as FANCD1/BRCA2 to chromatin. |
| 17643815 |
Knocking-down FANCD2 gene expression increases sensitivity of cancer cells to mitomycin C and to less extent to gamma-rays. Cell lines with significant FANCD2 depletion revealed decreased recurrence capacity. |
| 15454491 |
The carboxy terminus of FANCD2-44 plays a critical role in sensing or repairing DNA damage. |
| 15849361 |
FANCD2 bound to DNA with specificity for certain structures: double strand DNA ends and Holliday junctions |
| 16943440 |
These findings support the functional connection of ATM/ATR kinases and FANCD2 in the DNA damage response and support a role for the FA pathway in the coordination of the S phase of the cell cycle. |
| 16679306 |
FANCD2 single nucleotide polymorphisms may be associated with sporadic breast cancer risk |
| 12649160 |
Direct interaction between FANCE and FANCD2 involving an amino-terminal region of FANCD2 was demonstrated; this interaction may provide a link between the FA protein complex and its downstream targets. | →View more information from publications. |
Recent Publications on FANCD2: |  |
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction.
Fanconi anemia is a cancer-prone inherited bone marrow failure and cancer... | 29th October, 2009
| Department of Microbiology, University of Virginia Health System,
| Cancer Res. 2009 Oct 27.
DOI Direct Link |
Involvement of p29 in DNA damage responses and Fanconi anemia pathway.
Human p29 is a chromatin-associated protein and the silencing of p29... | 27th October, 2009
| Institute of Biochemical Sciences, National Taiwan University, No. 1,
| Carcinogenesis. 2009 Oct;30(10):1710-6. Epub 2009 Sep 11.
DOI Direct Link |
TLR8-dependent TNF{alpha} over-expression in Fanconi anemia group C cells.
A Fanconi anemia (FA) protein complex facilitates ubiquitinylation of... | 24th October, 2009
| Department of Biochemistry and Molecular Biology, Oregon Health & Science
| Blood. 2009 Oct 22.
DOI Direct Link |
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.
Genomic stability requires a functional Fanconi anemia (FA) pathway... | 20th October, 2009
| Department of Biochemistry, Oregon Health and Science University,
| J Biol Chem. 2009 Sep 18;284(38):25560-8. Epub 2009 Jul 24.
DOI Direct Link |
XPF-ERCC1 participates in the Fanconi anemia pathway of crosslink repair.
Interstrand crosslinks (ICLs) prevent DNA strand separation, and therefore... | 7th October, 2009
| Department of Human Genetics, University of Pittsburgh School of Public
| Mol Cell Biol. 2009 Oct 5.
DOI Direct Link |
→View more research publications. |
FANCD2 results (if any) from reagent suppliers | 
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FANCD2 antibody [103 ] (ab12450) | Abcam
Mouse monoclonal [103 ] to FANCD2. Fanconi Anemia (FANC) is a human autosomal- recessive cancer susceptibility disorder characterized by congenital defects,
...
http://www.abcam.com/FANCD2-antibody-103-ab12450.html...
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Phospho-FANCD2 (Ser222) Antibody #4945
Western blot analysis of extracts from untreated or UV-treated (50 mJ/cm2, 1hr) ME-180 and HT-29 cells, using Phospho-FANCD2 (Ser222) Antibody. ...
http://www.cellsignal.com/products/4945.html...
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FANCD2 (FI17) Antibody sc-20022
See how others have used FANCD2 (FI17): sc-20022 antibody and or FANCD2 (FI17) ... Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to ...
http://www.scbt.com/datasheet-20022-fancd2-fi17-antibody.htm...
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Phospho-FANCD2 (Ser222) Antibody
phosphorylation of FANCD2 at Ser222 and Ser1404 result- ing in an S-phase arrest (4). ... Antibody detects endogenous levels of FANCD2 only when ...
http://www.cellsignal.com/pdf/4945.pdf...
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FANCD2 antibody [FI-17] - ChIP Grade (ab5360) reviews | Abcam
9 May 2007 ... Mouse monoclonal [FI-17] to FANCD2 - ChIP Grade. Fanconi Anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder ...
http://www.abcam.com/index.html?pageconfig=reviews&intAbID=5...
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FANC Antibody / FANC Antibodies
FANCD2 (FI17) Antibody, sc-20022, mouse IgG1, N-terminus (h), WB, IP, human. FANCD2 (E-19) Antibody, sc-23584, goat IgG, C-terminus (h), WB, IP, IF, human
...
http://www.scbt.com/table-fanc.html...
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FANCD2 antibodies: Chromatin and Nuclear Signaling > DNA / RNA ...
FANCD2 antibodies. ... FANCD2 (phospho S222) antibody. ICC, WB. Rabbit polyclonal ... FANCD2 antibody (Hilyte Fluor™ 488). IHC-P, WB, ICC/IF, IP ...
http://www.abcam.com/index.html?t=8961&pt=1&c=880&ei=&mu=ra...
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