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FANCD2
| Symbol: | FANCD2 | | Name(s): | Fanconi anemia, complementation group D2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DKFZp762A223, FA-D2, FA4, FACD, FAD, FAD2, FANCD, FLJ23826 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18270339 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 18029388 |
Loss of CHK1 function impedes DNA dmage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia. |
| 16679306 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17898070 |
Study found that Fanconi anemia pathway activation is triggered mainly by the HPV type 16 (HPV-16) E7 oncoprotein and is associated with an enhanced formation of large FANCD2 foci and recruitment of FANCD2 as well as FANCD1/BRCA2 to chromatin. |
| 17643815 |
Knocking-down FANCD2 gene expression increases sensitivity of cancer cells to mitomycin C and to less extent to gamma-rays. Cell lines with significant FANCD2 depletion revealed decreased recurrence capacity. |
| 15454491 |
The carboxy terminus of FANCD2-44 plays a critical role in sensing or repairing DNA damage. |
| 15849361 |
FANCD2 bound to DNA with specificity for certain structures: double strand DNA ends and Holliday junctions |
| 16943440 |
These findings support the functional connection of ATM/ATR kinases and FANCD2 in the DNA damage response and support a role for the FA pathway in the coordination of the S phase of the cell cycle. |
| 16679306 |
FANCD2 single nucleotide polymorphisms may be associated with sporadic breast cancer risk |
| 12649160 |
Direct interaction between FANCE and FANCD2 involving an amino-terminal region of FANCD2 was demonstrated; this interaction may provide a link between the FA protein complex and its downstream targets. | →View more information from publications. |
Recent Publications on FANCD2: |  |
Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.
Fanconi anemia (FA) is a genetically heterogeneous, autosomal recessive... | 22nd January, 2010
| Division of Pediatric Hematology/Oncology, Children's Hospital Boston and
| Blood. 2010 Jan 20.
DOI Direct Link |
FANCD2 hurdles the DNA interstrand crosslink.
Left unrepaired, DNA interstrand crosslinks represent impassable hurdles... | 22nd January, 2010
| Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard
| Cell. 2009 Dec 24;139(7):1222-4.
DOI Direct Link |
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
Fanconi anemia is a human cancer predisposition syndrome caused by... | 22nd January, 2010
| Department of Biological Chemistry and Molecular Pharmacology, Harvard
| Science. 2009 Dec 18;326(5960):1698-701. Epub 2009 Nov 12.
DOI Direct Link |
The involvement of FANCM, FANCI, and checkpoint proteins in the interstrand DNA crosslink repair pathway is conserved in C. elegans.
Fanconi anemia (FA) patients are specifically defective in the repair of... | 16th January, 2010
| Department of Biochemistry, College of Life Science & Biotechnology,
| DNA Repair (Amst). 2010 Jan 12.
DOI Direct Link |
Role of ubiquitination in the DNA damage response: proteomic analysis to identify new DNA-damage-induced ubiquitinated proteins.
The DDR (DNA damage response) is a signalling transduction cascade... | 16th January, 2010
| DNA Damage Response Group, Basic Medical Science, St George's University
| Biochem Soc Trans. 2010 Feb;38(Pt 1):87-91.
DOI Direct Link |
→View more research publications. |
FANCD2 results from Abnova |  | Sponsored Results: |
| FANCD2 polyclonal antibody
Rabbit polyclonal antibody raised against partial recombinant FANCD2. Symbol: FANCD2 Alias: DKFZp762A223, FA-D2, FA4, FACD, FAD, FAD2, FANCD, FLJ23826
http://www.abnova.com/products/products_detail.asp?catalog_id=PAB12428 |  |
| FANCD2 (phospho S222) polyclonal antibody
Rabbit polyclonal antibody raised against synthetic phosphopeptide of FANCD2. Symbol: FANCD2 Alias: DKFZp762A223, FA-D2, FA4, FACD, FAD, FAD2, FANCD, FLJ23826
http://www.abnova.com/products/products_detail.asp?catalog_id=PAB12530 | |
→Search for FANCD2 products at Abnova. |
FANCD2 results (if any) from reagent suppliers | 
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Search Bioportfolio and other Life Science Sites for FANCD2,
or search for FANCD2 on BioPortfolio's antibody search engine.
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