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ACSL4


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Symbol:ACSL4
Name(s):acyl-CoA synthetase long-chain family member 4
Type:protein-coding
Organism:Homo sapiens
Synonyms:ACS4, FACL4, LACS4, MRX63, MRX68
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15108178 Observational study of gene-disease association. (HuGE Navigator)
17934335 FACL4 affects HCC cell growth and suggest that modulation of FACL4 expression/activity is an approach for treatment of HCC.
12525535 FACL4 is highly expressed in hippocampal and cerebellar neurons and may have a role in X linked mental retardation.
16276108 Disruption of DMD and the absence of ACSL4 in a patient are responsible for neuromuscular disease and cognitive impairment.
12824887 Overexpression of Fatty acid-CoA ligase 4 is associated with human hepatocellular carcinoma
15849811 FACL4 is involved in the hepatocellular carcinoma tumorigenesis and both cAMP and p38 MAPK pathways are associated with the regulation of FACL4
11889465 FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation
11731423 Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma.

Recent Publications on ACSL4:

Pubmed Logo
Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells.
Supplementation of long-chain polyunsaturated fatty acids (LCPUFAs) is...
3rd November, 2009
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Placenta. 2009 Oct 30.
DOI Direct Link
Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp/BMP production and visual wiring in the brain.
Long-chain acyl-CoA synthetases (ACSLs) convert long-chain fatty acids to...
21st July, 2009
Institute of Genetics and Developmental Biology, Chinese Academy of Hum Mol Genet. 2009 Oct 15;18(20):3894-905. Epub 2009 Jul 19.
DOI Direct Link
The XLMR gene ACSL4 plays a role in dendritic spine architecture.
ACSL4 is a gene involved in non-syndromic X-linked mental retardation. It...
18th June, 2009
Medical Genetics Unit, Department of Molecular Biology, University of Neuroscience. 2009 Mar 17;159(2):657-69. Epub 2008 Dec 24.
DOI Direct Link
Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.
AIMS: We investigated whether polymorphisms in candidate genes involved in...
17th April, 2009
Division of Diabetes, Department of Medicine, University of Helsinki, Eur J Endocrinol. 2009 Apr;160(4):593-602. Epub 2009 Feb 10.
DOI Direct Link
Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle.
BACKGROUND: Fatty acid composition has become an important trait in the...
6th February, 2009
Laboratory of Animal Breeding & Genetics, Graduate School of Agricultural BMC Genet. 2008 Dec 11;9:84.
DOI Direct Link

View more research publications.

ACSL4 results (if any) from reagent suppliers

Google CSE Logo
HPA005552 Anti-ACSL4 antibody produced in rabbit Ab2, Prestige ...
HPA005552 Anti-ACSL4 antibody produced in rabbit Ab2, Prestige Antibodies Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous
glycerol ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=HPA0...

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ACSL4 (K-12) Antibody sc-47996
goat polyclonal IgG, 200µg/ml; epitope mapping within an internal region of ACSL4 of human origin; recommended for detection of short isoform and long ...
http://www.scbt.com/datasheet-47996-acsl4-k-12-antibody.html...

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Abgent - Cell and Function Antibodies
AP2535a, ACSL3 (FACL3) Antibody (N-term), WB, IHC, E, H. AP2536b, ACSL4 (FACL4) Antibody (Center), WB, IHC, E, H. AP2536a, ACSL5 (FACL5) Antibody (N-term) ...
http://www.abgent.com/products/category/cell_function...

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ACSL Antibody / ACSL Antibodies
ACSL4 (H-53) Antibody, sc-134507, rabbit IgG, 623-675 (h), WB, IP, ... ACSL4 (N- 18) Antibody, sc-47997, goat IgG, N-terminus (h), WB, IP, IF, ELISA, m, r, h ...
http://www.scbt.com/table-acsl.html...

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Abgent - Neurosciences Antibodies
AP7100b, AATK Antibody (C-term), WB, IHC, E, H. AP7100dNEW, AATK Antibody ( Center), WB, IHC, E, H. AP2536b, ACSL4 (FACL4) Antibody (Center), WB, IHC, E, H
...
http://www.abgent.com/products/category/neurosciences...

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ACSL Antibody / ACSL Antibodies
ACSL4 (K-12) Antibody, sc-47996, goat IgG, Internal (h), WB, IF, ELISA, m, r, h ... ACSL4 (N-18) Antibody, sc-47997, goat IgG, N-terminus (h), WB, IP, IF, ...
http://www.scbt.com/ko/table-acsl.html...

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Citations
ACSL4 (FACL4) Antibody (Center). Estela Area-Gomez, et al. Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria. ...
http://www.abgent.com/docs/citation...

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