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PTK2B
| Symbol: | PTK2B | | Name(s): | PTK2B protein tyrosine kinase 2 beta | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CADTK, CAKB, FADK2, FAK2, FRNK, PKB, PTK, PYK2, RAFTK | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17950644 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18075463 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17581868 |
REVIEW: role of PYK2 in bone resorption and possible target to prevent osteoporosis |
| 18075463 |
Missense mutation in PTK2B gene is associated with hypertension |
| 17563746 |
ErbB-2, via PYK2-MAP kinase, upregulates the adhesive ability of androgen receptor human prostate cancer cells. |
| 17785844 |
Endothelial Pyk2 activity is required for efficient neutrophil migration and to facilitate junctional disruption during transcellular or paracellular passage of the leukocyte across the vascular endothelial monolayer. |
| 16998626 |
FRNK plays an important role in cell adhesion during the very early stages of cell culture. |
| 17551499 |
overexpression of Pyk2 and FAK was found in nearly 60% of HCC patients and was significantly correlated with poor prognosis |
| 15778498 |
Pyk2 has a role in the reduced cell-cell adhesion induced by the Rac-mediated production of ROS through the tyrosine phosphorylation of beta-catenin |
| 16055703 |
Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway | →View more information from publications. |
Recent Publications on PTK2B: |  |
An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages.
MIP-1beta/CCL4 is a principal regulator of macrophage migration and... | 21st October, 2009
| Pulmonary, Allergy and Critical Care, Department of Medicine, University
| J Leukoc Biol. 2009 Oct;86(4):833-45. Epub 2009 Jul 20.
DOI Direct Link |
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.
Tyrosine phosphorylation is important in signaling pathways underlying... | 15th October, 2009
| Cancer Genetics Branch, National Human Genome Research Institute, National
| Nat Genet. 2009 Oct;41(10):1127-32. Epub 2009 Aug 30.
DOI Direct Link |
The role of the scavenger receptor CD36 in regulating mononuclear phagocyte trafficking to atherosclerotic lesions and vascular inflammation.
AIMS: CD36 has been shown to associate with non-receptor Src kinases to... | 14th October, 2009
| Faculty of Pharmacy, Universite de Montreal, Station Centre-Ville,
| Cardiovasc Res. 2009 Jul 1;83(1):42-51. Epub 2009 Mar 5.
DOI Direct Link |
B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading.
Signaling by the B cell receptor (BCR) promotes integrin-mediated adhesion... | 7th October, 2009
| Department of Microbiology and Immunology, Life Sciences Institute,
| J Biol Chem. 2009 Aug 21;284(34):22865-77. Epub 2009 Jun 26.
DOI Direct Link |
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin.
Macrophage colony-stimulating factor (M-CSF) influences the proliferation... | 19th September, 2009
| Department of Pathology and Immunology, Washington University School of
| Nat Immunol. 2009 Jul;10(7):734-43. Epub 2009 Jun 7.
DOI Direct Link |
→View more research publications. |
PTK2B results (if any) from reagent suppliers | 
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PTK2B Recombinant Human PTK2B Protein Tyrosine Kinase 2 beta
Recombinant human full length PTK2B with N-terminal His tag. Formulation: ... + 30 µg/ml Poly (Glu:Tyr) 4:1 substrate + 4 µg/ml recombinant PTK2B. ...
http://www.cellsciences.com/PDF/PTP071.pdf...
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Purified Anti-PYK2 Antibody - BioLegend
Purified Anti-PYK2 Antibody - PYK2, a 116 kD proline-rich non-receptor tyrosine kinase also known as FAK2 or PTK2B, is ubiquitously expressed in the ...
http://www.biolegend.com/purified-anti-pyk2-antibody-2060.ht...
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PYK2 (N-19) Antibody sc-1514
Human, PTK2B, 2185, 8p21.2, NM_004103, NM_173174, NM_173175, NM_173176 · Q14289 · 601212. Mouse, Ptk2b, 19229, 14 D1, Q9QVP9 ...
http://www.scbt.com/datasheet-1514-pyk2-n-19-antibody.html...
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Purified Anti-p130 Cas Antibody - BioLegend
Interaction: v-Crk, v-Src, nephrocystin, PTK2B, CrkII. Forms complexes with Fak1 , CrkL, Lyn kinase; heterodimerizes with CasL. Antigen References: 1. ...
http://www.biolegend.com/purified-anti-p130-cas-antibody-213...
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FAK antibody, FAK (Ab-925) Antibody, Rabbit Polyclonal Antibody
KEGG pathway: VEGF signaling pathway 04370. Products similar to FAK antibody: IgG. PTK2B (PTK2B protein tyrosine kinase 2 beta), IgG · FAK (Ab-861), IgG ...
http://www.genwaybio.com/product_info.php?products_id=210161...
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EWSR1 antibody (ab36796) | Abcam
Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation. Research areas . Chromatin and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA ...
http://www.abcam.com/EWSR1-antibody-ab36796.html...
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alpha Synuclein antibody, alpha Synuclein Antibody, Rabbit ...
Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress. Ptm: Hallmark lesions of neurodegenerative synucleinopathies contain ...
http://www.genwaybio.com/product_info.php?products_id=196445...
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