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FANCF


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Gene DB Home
Symbol:FANCF
Name(s):Fanconi anemia, complementation group F
Type:protein-coding
Organism:Homo sapiens
Synonyms:FAF, MGC126856
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15262960 FANCF acts as a flexible adaptor protein that plays a key role in the proper assembly of the FA core complex.
16418574 results showed that FANCF methylation regulates the expression of FANCF at both mRNA and protein levels; methylation-induced inactivation of FANCF plays an important role in the occurrence of ovarian cancers via disrupting the FA-BRCA pathway
17082180 human FANCF protein has specific structural components that function in the assembly of a DNA damage signaling complex
15126331 Inactivation of genes in the FA-BRCA pathway by epigenetic alterations have been found in a high proportion of cervix cancer patients, suggesting a major role for this pathway in the development of cervical cancer.
14647419 inactivation of the FANC-BRCA pathway is relatively common in solid tumors and may be related to tobacco and alcohol exposure and survival

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDFanconi anemia, complementation group AFanconi anemia, complementation group F--Pubmed
HPRDFanconi anemia, complementation group AFanconi anemia, complementation group F--Pubmed
HPRDFanconi anemia, complementation group CFanconi anemia, complementation group F--Pubmed
HPRDFanconi anemia, complementation group CFanconi anemia, complementation group F--Pubmed
HPRDFanconi anemia, complementation group FFanconi anemia, complementation group G--Pubmed
HPRDFanconi anemia, complementation group FFanconi anemia group G protein--Pubmed

Recent Publications on FANCF:

Pubmed Logo
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction.
Fanconi anemia is a cancer-prone inherited bone marrow failure and cancer...
29th October, 2009
Department of Microbiology, University of Virginia Health System, Cancer Res. 2009 Oct 27.
DOI Direct Link
Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas.
BACKGROUND: DNA repair genes critically regulate the cellular response to...
21st October, 2009
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Mol Cancer. 2009 Jul 14;8:48.
DOI Direct Link
Low incidence of methylation of the promoter region of the FANCF gene in Japanese primary breast cancer.
PURPOSE: The link between BRCA1 dysfunction and basal-like breast cancer...
9th October, 2009
Department of Surgery and Science, Graduate School of Medical Sciences, Breast Cancer. 2009 Oct 8.
DOI Direct Link
Hypermethylated SFRP1, but none of other nine genes "informative" for western countries, is valuable for bladder cancer detection in Mainland China.
PURPOSE: A 11-gene set by methylation-specific PCR in urine sediments for...
9th October, 2009
School of Medicine, Fudan University, 200032 Shanghai, China. J Cancer Res Clin Oncol. 2009 Dec;135(12):1717-27. Epub 2009 Jun 30.
DOI Direct Link
The interferon consensus sequence binding protein (ICSBP/IRF8) activates transcription of the FANCF gene during myeloid differentiation.
The interferon consensus sequence binding protein (ICSBP) is an interferon...
6th October, 2009
Northwestern University, United States; J Biol Chem. 2009 Oct 2.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
7531530 Therapeutic compounds
7507536 Methylation markers for diagnosis and treatment of ovarian cancer
7482334 Therapeutic treatment methods
7351701 Therapeutic compounds

View more patents.

FANCF results (if any) from reagent suppliers

Google CSE Logo
FANC Antibody / FANC Antibodies
FANCF (N-20) Antibody, sc-19327, goat IgG, internal (h), WB, IP, IF, ELISA, human. FANCF (K-18) Antibody, sc-19328, goat IgG, C-terminus (h), WB, IF, ELISA
...
http://www.scbt.com/table-fanc.html...

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Certificate of Analysis Product: Affinity Purified Anti-FANCF ...
Hoatlin,M.E., Joenje,H. and de Winter,J.P. (2004) The Fanconi anemia gene product FANCF is a flexible adaptor protein. J. Biol. Chem. 279 ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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FANCF peptide (ab49620) | Abcam
FANCF peptide. FANCF belongs to a multi subunit complex composed of FANCA, FANCC , FANCF and FANCG proteins. It is a DNA repair protein that may operate in ...
http://www.abcam.com/FANCF-peptide-ab49620.html...

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FANCF siRNA (h) sc-40570
Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: FANCF (h)-PR: sc-40570-PR, 20 µl ...
http://www.scbt.com/ja/datasheet-40570-fancf-sirna-h.html...

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FANCF proteins and peptides: Chromatin and Nuclear Signaling > DNA ...
FANCF proteins and peptides. ... Image Abreview Publication. ab49619 · FANCF peptide · ab49620 · FANCF peptide · Terms and conditions · Legal ...
http://www.abcam.com/index.html?t=30448&pt=2&c=880&ei=&mu=ra...

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FANCF (H-310) Antibody sc-28218
FANCF (H-310) Anticorpo sc-28218 FANCF (H-310) Antibody sc-28218.
http://www.scbt.com/pt/datasheet-28218-fancf-h-310-antibody....

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Page 1 of 2 e-mail: info@rockland-inc.com Visit our website at ...
BRCA2), FANCD2, FANCE, FANCF, FANCG, and ... Anti-Human FANCF (Rabbit). 600-401- 671. Anti-Human FANCG (Rabbit). #611-703-127 ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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