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FHIT


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Gene DB Home
Symbol:FHIT
Name(s):fragile histidine triad gene
Type:protein-coding
Organism:Homo sapiens
Synonyms:AP3Aase, FRA3B
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17359554 nasopharyngeal carcinoma patients with high titres of IgA against Epstein-Barr virus capsid antigen showed frequent loss of heterozygosity. Allelic loss at the FRA3B site occurs significantly more commonly in endemic nasopharyngeal carcinoma patients.
17712558 MTHFR variants were not related to FHIT hypermethylation in diffuse large B-cell lymphoma.
18338496 FHIT gene mutations in the formation of breast cancer. FHIT mutations were detected in 13 of the 67 malignant cases (19.4%) and 2 of the 16 benign cases (12.5%).
18338497 The FHIT gene may be turned off in brain metastases via other genetic/epigenetic mechanisms rather than mutations.
18006149 Results support the view that Ap3A is the in vivo Fhit ligand and that an inhibition of Fhit activity is a key element in Fhit-mediated apoptosis.
14675322 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17548701 Observational study of gene-disease association. (HuGE Navigator)
17609851 Observational study of gene-disease association. (HuGE Navigator)
17846126 Observational study of gene-disease association. (HuGE Navigator)
18097574 aberrant Fhit and Mlh1 expression could be related to colorectal carcinoma de novo (DN) carcinogenesis.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDfragile histidine triad geneubiquitin-conjugating enzyme E2I--Pubmed

Recent Publications on FHIT:

Pubmed Logo
Genome wide DNA-profiling of HIV-related B-cell lymphomas.
Summary Non-Hodgkin lymphomas (NHL) represent a frequent complication of...
17th October, 2009
Division of Haematology, Department of Clinical and Experimental Medicine Br J Haematol. 2009 Oct 12.
DOI Direct Link
Concordance of DNA methylation pattern in plasma and tumor DNA of Egyptian hepatocellular carcinoma patients.
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the...
13th October, 2009
Molecular Virology and Immunology Unit, Cancer Biology Department, Exp Mol Pathol. 2009 Oct 7.
DOI Direct Link
FHIT Gene Sequence Variants and Reduced Fhit Protein Expression in Glioblastoma Multiforme.
Molecular studies have an important role in the elucidation of the...
18th September, 2009
Department of Medical Biology, School of Medicine, Uludag University, Cell Mol Neurobiol. 2009 Sep 17.
DOI Direct Link
High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphoma.
Additional chromosomal abnormalities are currently detected in Burkitt's...
18th September, 2009
CNRS, FRE2939, Genomique Cellulaire des Cancers, Institut Gustave Roussy PLoS One. 2009 Sep 17;4(9):e7089.
DOI Direct Link
Comparative analysis of protein expression in differentiated thyroid tumours: a multicentre study.
This study compared clinical features and protein expression profiles in...
18th September, 2009
Department of Endocrinology, Ninth Affiliated Hospital, Guangxi Medical J Int Med Res. 2009 May-Jun;37(3):927-38.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7141417 Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
7285542 Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
7309604 Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins
7358048 Method for detection of promoter methylation status
7361466 Nucleic acid analysis using terminal-phosphate-labeled nucleotides

View more patents.

FHIT results (if any) from reagent suppliers

Google CSE Logo
Fhit (N-19) Antibody sc-8215
See how others have used Fhit (N-19): sc-8215 antibody and or Fhit ... Distribution of Fhit protein in rat tissues and its intracellular localization.
Mol. ...
http://www.scbt.com/datasheet-8215-fhit-n-19-antibody.html...

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The Abcam catalog
FHIT antibodies. ... FHIT antibody, prediluted. IHC-P. Rabbit polyclonal. Reacts with: Hu. Terms and conditions · Legal · Privacy policy ...
http://www.abcam.com/index.html?t=95499&pt=1&c=3393...

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Fhit (WW-7) Antibody sc-101231
mouse monoclonal IgG1, 100 µg/ml; raised against recombinant Fhit of human origin ... Western blot analysis of Fhit expression in HL-60 whole cell lysate.
...
http://www.scbt.com/datasheet-101231-fhit-ww-7-antibody.html...

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FHIT (Tyr114) Biotinylated Peptide
FHIT (Tyr114). Biotinylated Peptide rev. 12/18/07. ■ 1.25 ml at 6µM ... residues surrounding Tyr114 of FHIT. It was generated for ...
http://www.cellsignal.com/pdf/1365.pdf...

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Fhit (C-20) Antibody sc-8214
goat polyclonal IgG, 200 µg/ml; epitope mapping near the C-terminus of Fhit of human origin; recommended for detection of Fhit of human origin by WB, IP, ...
http://www.scbt.com/datasheet-8214-fhit-c-20-antibody.html...

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www.hypromatrix.com Hypromatrix, Inc.
Fhit is member of the histidine triad protein family. It is a ... This antibody reacts specifically with Fhit of human origin by ...
http://www.hypromatrix.com/Products/Primary_Antibody/FHIT.pd...

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Fhit (m): 293T Lysate sc-120253
100 µg protein in 200 µl SDS-PAGE buffer; suitable as Western Blotting control for Fhit antibodies; mouse Fhit transfected 293T lysate; suitable control ...
http://www.scbt.com/datasheet-120253-fhit-m-293t-lysate.html...

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