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FKBP1A
| Symbol: | FKBP1A | | Name(s): | FK506 binding protein 1A, 12kDa | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FKBP-12, FKBP1, FKBP12, FKBP12C, PKC12, PKCI2, PPIASE | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17962721 |
FKBP12 is predominantly present during early neointima formation, while mature neointimal atheromas show a relatively low expression without confinement to luminal areas. |
| 18029417 |
fndings suggest that the peptidyl-prolyl isomerase activity requires only the hydrophobic cavity that captures the Pro-containing peptide |
| 17872463 |
FKBP12.0-RyR2 interaction can regulate the gain of excitation-contraction coupling in cardiomyocytes |
| 16410343 |
FKBP12 accelerated the aggregation of alpha-synuclein in vitro. |
| 12850152 |
folding and kinetics of human FKBP12 |
| 16036432 |
The spinal horn neurons stained with anti-FKBP 12 antibody was significantly decreased in the motor neuron disease cases compared to that in controls. |
| 14970260 |
the central binding site for the 12 kDa FK506-binding protein of type-3 ryanodine receptor, encompassing the critical valine proline motif, plays a crucial role in the modulation of the Ca2+ release properties |
| 15992823 |
experimental data on the stability of FKBP12 are reported for the effects of three environmental variables: pH, salt, and macromolecular crowding |
| 16720724 |
These findings indicate a new inhibitory function of FKBP12 as an adaptor molecule for the Smad7-Smurf1 complex to regulate the duration of the activin signal through activin type I receptors. |
| 16908189 |
characterization of the stability, binding and enzymatic properties of three FK506 binding proteins (FKBP-12) differing only by the length and sequence of their N-terminus | →View more information from publications. |
Recent Publications on FKBP1A: |  |
The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization.
Patients with classic fibrodysplasia ossificans progressiva, a disorder... | 27th October, 2009
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| J Clin Invest. 2009 Nov 2;119(11):3462-3472. doi: 10.1172/JCI37412. Epub
DOI Direct Link |
mTOR regulates memory CD8 T-cell differentiation.
Memory CD8 T cells are a critical component of protective immunity, and... | 21st August, 2009
| Emory Vaccine Center and Department of Microbiology and Immunology,
| Nature. 2009 Jul 2;460(7251):108-12. Epub 2009 Jun 21.
DOI Direct Link |
High-resolution multi-dimensional NMR spectroscopy of proteins in human cells.
In-cell NMR is an isotope-aided multi-dimensional NMR technique that... | 22nd April, 2009
| Department of Molecular Engineering, Graduate School of Engineering, Kyoto
| Nature. 2009 Mar 5;458(7234):106-9.
DOI Direct Link |
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.
Ca(2+)-release-activated Ca(2+) (CRAC) channels generate sustained Ca(2+)... | 13th September, 2008
| Department of Molecular and Cellular Physiology, Stanford University
| Nature. 2008 Jul 24;454(7203):538-42. Epub 2008 Jul 2.
DOI Direct Link |
Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus.
The human and rat hippocampus is highly susceptible to iron deficiency... | 1st November, 2007
| Medical Scientist Training Program, Department of Pediatrics, University
| Hippocampus. 2007;17(8):679-91.
DOI Direct Link |
→View more research publications. |
FKBP1A results (if any) from reagent suppliers | 
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FKBP12 Antibody (Center)
Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; EC 5.2.1.8; FK506- binding protein 1A; FKBP-1A; Rotamase; Immunophilin FKBP12; 12 kDa FKBP; ...
http://www.abgent.com/products/catalog_no/AP7756c_FKBP12_Ant...
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FKBP12 (N-19) Antibody sc-6174
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, FKBP1A, 2280, 20p13, NM_000801, ...
http://www.scbt.com/datasheet-6174-fkbp12-n-19-antibody.html...
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Human T Cell Enrichment Column
FK506 binding protein, also called FKBP12 and FKBP1A, was originally characterized as a peptidyl-prolyl isomerase that catalyzes the transition
between cis- ...
http://www.rndsystems.com/pdf/MAB3777.pdf...
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C1988 Cycloheximide Biotechnology Performance Certified
total impurities, Endotoxin, tested. suitability, cell culture tested. Gene Information, human ... FKBP1A(2280), PIN1(5300). storage temp. 2-8°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C198...
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New Products: Enzymes
FKBP1A, Recombinant Human FK506 Binding Protein 1A. FKBP4, Recfombinant Human FK506 Binding Protein 4. FTCD, Recombinant Human Formiminotransferase ...
http://www.atsbio.com/catalog/new-enzymes.html...
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C4859 Cycloheximide solution CHX Ready-Made Solution, microbial ...
biological source, microbial. sterility, 0.2 μm filtered. concentration, 100 mg/ mL in DMSO. Gene Information, human ... FKBP1A(2280), PIN1(5300) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C485...
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C7698 Cycloheximide from microbial, ≥94% (TLC)
biological source, from microbial. assay, ≥94% (TLC). solubility, ethanol: clear to hazy. Gene Information, human ... FKBP1A(2280), PIN1(5300) ...
https://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C76...
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