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XRN2


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Gene DB Home
Symbol:XRN2
Name(s):5'-3' exoribonuclease 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17639083 p54 is present along the length of genes, and small interfering RNA (siRNA)-mediated knockdown leads to defects in XRN2 recruitment and termination.
16147866 XRN2b is mainly expressed in blood leukocyte tissue, while XRN2a is detected in several human tissues and in human tumor tissues
15565158 co-transcriptional cleavage acts as a precursor to termination by presenting a free RNA 5' end that is recognized by the human 5' --> 3' exonuclease Xrn2

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcatechol-O-methyltransferase isoform MB-COMT5'-3' exoribonuclease 2--Pubmed
HPRDcatechol-O-methyltransferase isoform MB-COMT5'-3' exoribonuclease 2--Pubmed
HPRDDOM-3 homolog Z5'-3' exoribonuclease 2--Pubmed
HPRDDOM-3 homolog Z5'-3' exoribonuclease 2--Pubmed
HPRDeukaryotic translation elongation factor 1 alpha 15'-3' exoribonuclease 2--Pubmed
HPRDeukaryotic translation initiation factor 5A5'-3' exoribonuclease 2--Pubmed
HPRDexosome component 10 isoform 15'-3' exoribonuclease 2--Pubmed
HPRDexosome component 10 isoform 15'-3' exoribonuclease 2--Pubmed
HPRDproteasome alpha 3 subunit isoform 15'-3' exoribonuclease 2--Pubmed
HPRD5'-3' exoribonuclease 2TAR DNA binding protein--Pubmed

Recent Publications on XRN2:

Pubmed Logo
Coupled RNA processing and transcription of intergenic primary microRNAs.
The first step in microRNA (miRNA) biogenesis occurs in the nucleus and is...
12th August, 2009
University of Rome La Sapienza, P.le A. Moro 5, 00185 Rome, Italy. Mol Cell Biol. 2009 Oct;29(20):5632-8. Epub 2009 Aug 10.
DOI Direct Link
A novel tandem reporter quantifies RNA polymerase II termination in mammalian cells.
BACKGROUND: Making the correct choice between transcription elongation and...
10th July, 2009
The Department of Genetics, Louisiana State University Health Sciences PLoS One. 2009 Jul 9;4(7):e6193.
DOI Direct Link
FIERY1 regulates light-mediated repression of cell elongation and flowering time via its 3'(2'),5'-bisphosphate nucleotidase activity.
Light is one of the most important environmental factors that regulate...
29th May, 2009
Department of Biochemistry and Cellular and Molecular Biology, The Plant J. 2009 Apr;58(2):208-19. Epub 2008 Dec 10.
DOI Direct Link
Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.
The 5'-->3' exoribonucleases (XRNs) comprise a large family of conserved...
21st April, 2009
Department of Biological Sciences, Columbia University, New York, New York Nature. 2009 Apr 9;458(7239):784-8. Epub 2009 Feb 4.
DOI Direct Link
Studies of the 5' exonuclease and endonuclease activities of CPSF-73 in histone pre-mRNA processing.
Processing of histone pre-mRNA requires a single 3' endonucleolytic...
15th January, 2009
Program in Molecular Biology and Biotechnology, CB #3280, University of Mol Cell Biol. 2009 Jan;29(1):31-42. Epub 2008 Oct 27.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7585969 MicroRNA and methods for inhibiting same
7416842 DNA virus microRNA
7365058 MicroRNA and methods for inhibiting same
7235358 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

XRN2 results (if any) from reagent suppliers

Google CSE Logo
XRN2 antibody (ab72181) | Abcam
Rabbit polyclonal to XRN2. XRN2 possesses 5'->3' exoribonuclease activity. XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene.
http://www.abcam.com/XRN2-antibody-ab72181.html...

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XRN Antibody / XRN Antibodies
XRN2 (N-20) Antibody, sc-50212, goat IgG, N-terminus (h), WB, IF, ELISA, m, r, h . XRN2 (P-17) Antibody, sc-50213, goat IgG, Internal (h), WB, IF, ELISA ...
http://www.scbt.com/table-xrn.html...

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XRN2 antibodies: Chromatin and Nuclear Signaling > DNA / RNA > RNA ...
XRN2 antibodies. ... XRN2 antibody. IHC-P, ICC/IF. Images. Rabbit polyclonal. Reacts with: Hu, Ms. ab74799 · XRN2 antibody. IHC-P, WB, ELISA ...
http://www.abcam.com/index.html?t=269518&pt=1&c=3276&ei=&mu=...

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XRN1 Antibody Bethyl Laboratories
Rabbit anti-XRN2 Antibody, Affinity Purified · A301-102A · Rabbit anti-XRN2 Antibody, Affinity Purified · A301-101A · Rabbit anti-XRN2 Antibody, ...
http://www.bethyl.com/go/?product/A300-443A...

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XRN2 siRNA (m) sc-61814
Click here for details. suitable control antibody: XRN2 (N-20): sc-50212; sqRT- PCR Primer also available: XRN2 (m)-PR: sc-61814, 20 µl ...
http://www.scbt.com/ko/datasheet-61814-xrn2-sirna-m.html...

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PSF/SFPQ Bethyl Laboratories
Additionally, it has recently been show to associate with XRN2 and p54nrb/NonO to facilitate pre-mRNA 3' processing and transcription termination.
http://www.bethyl.com/category/PSF_SFPQ/Antibody/AAAAAAAABAA...

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XRN2 (N-20) Antibody sc-50212
XRN2 (N-20) 抗体sc-50212 XRN2 (N-20) Antibody sc-50212.
http://www.scbt.com/zh/datasheet-50212-xrn2-n-20-antibody.ht...

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