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P2RX2


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Symbol:P2RX2
Name(s):purinergic receptor P2X, ligand-gated ion channel, 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC129601, P2X2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12395104 Whole-cell voltage clamp recordings functionally correlated immunolocalisation of ATP-gated ion channels in isolated hair cells and supporting cells. P2X immunoreactivity was widespread throughout the epithelial lining of the cochlea.
15331767 Effect of acute hypoxia on cloned homo- and heteromeric P2X2 receptors expressed in human embryonic kidney 293 cells.
15313628 Data provide biochemical evidence that in addition to the rapidly desensitising P2X1 and P2X3 receptors, the slowly desensitising subtypes P2X2, P2X4, and P2X5 are trimers of identical subunits.
15657042 P2X(2) receptors are trimers, whereas the P2X(6) receptor subunits do not form stable oligomers

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDGamma aminobutyric acid receptor, rho 1purinergic receptor P2X2 isoform D--Pubmed
HPRDgamma-aminobutyric acid receptor, rho 1Purinergic receptor P2X ligand gated ion channel 2--Pubmed
HPRDPurinergic receptor P2X ligand gated ion channel 1purinergic receptor P2X2 isoform D--Pubmed
HPRDPurinergic receptor P2X ligand gated ion channel 3purinergic receptor P2X2 isoform D--Pubmed
HPRDpurinergic receptor P2X2 isoform Dpurinergic receptor P2X2 isoform D--Pubmed

Recent Publications on P2RX2:

Pubmed Logo
Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish.
The hypocretin/orexin (HCRT/ORX) excitatory neuropeptides are expressed in...
11th March, 2008
Department of Psychiatry and Behavioral Sciences, Stanford University, Brain Res. 2007 Oct 12;1174:66-75. Epub 2007 Aug 9.
DOI Direct Link
Retinoic acids increase P2X2 receptor expression through the 5'-flanking region of P2rx2 gene in rat phaeochromocytoma PC-12 cells.
The P2X2 receptor is a subtype of ionotropic ATP receptor and plays a...
25th October, 2006
Department of Molecular and System Pharmacology, Graduate School of Mol Pharmacol. 2006 Jul;70(1):319-28. Epub 2006 Apr 25.
DOI Direct Link
Smooth muscle and purinergic contraction of the human, rabbit, rat, and mouse testicular capsule.
The smooth-muscle cells of the testicular capsule (tunica albuginea) of...
11th November, 2005
Autonomic Neuroscience Centre, Royal Free Hospital, London NW3 2PF, United Biol Reprod. 2006 Mar;74(3):473-80. Epub 2005 Nov 9.
DOI Direct Link

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods
7447594 Molecular cardiotoxicology modeling

P2RX2 results (if any) from reagent suppliers

Google CSE Logo
CHO PhotoScreen® P2RX2/P2rx3 Cell Line from PerkinElmer - USA
The clone has been selected to have mainly a P2RX2/P2rx3 heteromer response, and a protocol was developed to allow screening specifically of the P2RX2/3 ...
http://las.perkinelmer.com/Catalog/ProductInfoPage.htm?Produ...

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P2X2 (H-116) Antibody sc-25693
Human, P2RX2, 22953, 12q24.33, NM_012226, NM_016318, NM_170682, NM_170683, NM_174872, NM_174873 · Q9UBL9 · 600844. Mouse, P2rx2, 231602, 5 F, NP_700449 ...
http://www.scbt.com/datasheet-25693-p2x2-h-116-antibody.html...

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P1-PC
HPA014025, Anti-P2RX2 antibody produced in rabbit, (polyclonal), affinity isolated antibody, human ... P2RX2(22953), human, IHC (p), PA, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Antibodies to P2X Receptors
P2rx2(114115), rat, IHC (p), WB CL, pricing. P8107, Anti-P2X4 Purinergic Receptor antibody produced in rabbit, (polyclonal), affinity isolated antibody
...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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P2X2 (S-16) Antibody sc-12212
ヒト, P2RX2, 22953, 12q24.33, NM_012226, NM_016318, NM_170682, NM_170683, NM_174872, NM_174873 · Q9UBL9 · 600844. マウス, P2rx2, 231602, 5 F, NP_700449
...
http://www.scbt.com/ja/datasheet-12212-p2x2-s-16-antibody.ht...

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Search Results
Stock# - 004603 Strain name - B6.129-P2rx2/J JAX® Mice Database Site Section: JAX® Mice and services · jaxmice.jax.org/strain/004603.html - 30Kb ...
http://www.jax.org/search/Main.jsp?sg=0&qt=technicians&page=...

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P2X2 (S-16) Antibody sc-12212
Human, P2RX2, 22953, 12q24.33, NM_012226, NM_016318, NM_170682, NM_170683, NM_174872, NM_174873 · Q9UBL9 · 600844. Maus, P2rx2, 231602, 5 F, NP_700449 ...
http://www.scbt.com/de/datasheet-12212-p2x2-s-16-antibody.ht...

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