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SPEN
| Symbol: | SPEN | | Name(s): | spen homolog, transcriptional regulator (Drosophila) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | KIAA0929, MINT, RP1-134O19.1, SHARP | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15062576 |
both the androgen receptor interacting domains of the coactivator SRC1 and of the corepressor SMRT compete for interaction with the androgen receptor N-terminus |
| 16583136 |
Msx2-interacting protein(MINT), human interacts with the UbcH8. |
| 12374742 |
SHARP is a novel component of the HDAC corepressor complex, recruited by RBP-Jkappa to repress transcription of target genes in the absence of activated Notch. |
| 15824732 |
Pak1-SHARP interaction plays an essential role in enhancing the corepressor functions of SHARP, thereby modulating Notch signaling in human cancer cells. |
| 17234755 |
SHARP gene and protein expression is elevated in human colon and ovarian endometrioid adenocarcinomas carrying gene defects leading to beta-catenin dysregulation. |
| 12897056 |
the conserved function of the SPOC domain of SHARP is to mediate interaction with SMRT/NCoR corepressors, and that Spen proteins play an essential role in the repression complex |
Recent Publications on SPEN: |  |
NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells.
BACKGROUND: Homeodomain proteins control fundamental cellular processes in... | 20th October, 2009
| Dept. of Human and Animal Cell Lines, DSMZ - German Collection of
| BMC Cancer. 2009 Oct 19;9:371.
DOI Direct Link |
The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
The human SPEN family proteins SHARP, RBM15/OTT1, and RBM15B/OTT3 share... | 20th October, 2009
| Human Retrovirus Section, Center for Cancer Research, NCI, National
| J Biol Chem. 2009 Sep 18;284(38):26106-16. Epub 2009 Jul 8.
DOI Direct Link |
ACE inhibition and protection from doxorubicin-induced cardiotoxicity in the rat.
The angiotensin converting enzyme inhibitor zofenopril has been shown to... | 12th September, 2009
| Department of Pharmacology, Menanni Ricerche, Via Tito Spen 10, 00040
| Vascul Pharmacol. 2009 May-Jun;50(5-6):166-70.
DOI Direct Link |
Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas.
Recent studies have revealed the epigenetic alterations are involved in... | 27th May, 2009
| Department of Pathology, The University of Texas MD Anderson Cancer
| Mod Pathol. 2009 Mar;22(3):442-9. Epub 2009 Jan 9.
DOI Direct Link |
Requirement of Split ends for epigenetic regulation of Notch signal-dependent genes during infection-induced hemocyte differentiation.
Drosophila producing a mutant form of the putative transcription... | 21st April, 2009
| Department of Biochemistry, Yonsei University, Seoul, Republic of Korea.
| Mol Cell Biol. 2009 Mar;29(6):1515-25. Epub 2009 Jan 12.
DOI Direct Link |
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Recent Search Terms used to find this page: SPEN SEX | spensex | SPCS3 leukemia | SPCS3 leukemia | spen homolog | spen puplications | Spenito and Split ends act redundancy to promote Wingless signaling | .
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