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WAPAL


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Gene DB Home
Symbol:WAPAL
Name(s):wings apart-like homolog (Drosophila)
Type:protein-coding
Organism:Homo sapiens
Synonyms:FOE, KIAA0261, WAPL
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17113138 Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin.
17382297 our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability.
17112726 Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits
15383329 FOE encodes a protein of 1227 amino acids with a functional bipartite nuclear localization signal, an arginine-rich motif, a putative nuclear export signal as well as with three highly acidic regions and a predicted coiled-coil domain.

Recent Publications on WAPAL:

Pubmed Logo
Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1.
The cohesin complex establishes sister chromatid cohesion during S phase....
23rd September, 2009
Chromosome Dynamics Laboratory, RIKEN Advanced Science Institute, Wako, Genes Dev. 2009 Sep 15;23(18):2224-36. Epub 2009 Aug 20.
DOI Direct Link
[Prokaryotic expression and immunogenicity of hWAPL, a norel oncogene related to cervical cancer]
AIM: To construct the prokaryotic expression plasmid of hWAPL, induce the...
1st May, 2009
Department of Microbiology, Medical College, Xi'an Jiaotong University, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Jun;23(6):562-4.
Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia.
We have previously identified a novel gene WAPL that is inducible by human...
17th December, 2008
Department of Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Gene. 2008 Oct 15;423(1):57-62. Epub 2008 Jul 10.
DOI Direct Link
Immunization of mice with plasmids coexpressing HPV16 E5 and the novel oncogene hWAPL.
The novel human oncogene hWAPL is associated with uterine cervical cancer....
19th July, 2008
Microbiology Department of Medical College, Xi'an Jiaotong University, Int J Gynecol Cancer. 2008 May-Jun;18(3):534-9. Epub 2007 Jul 21.
DOI Direct Link
Unscheduled overexpression of human WAPL promotes chromosomal instability.
Previously, we have isolated and characterized a novel human gene termed...
7th June, 2007
Department of Pathology, Tokyo Medical University, Shinjuku, Shinjuku-ku, Biochem Biophys Res Commun. 2007 May 11;356(3):699-704. Epub 2007 Mar 15.
DOI Direct Link

View more research publications.

WAPAL results (if any) from reagent suppliers

Google CSE Logo
WAPL Antibody / WAPL Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. WAPL (A-17) Antibody, sc-82118, goat IgG, Internal (h), WB, IF, ELISA, m, r, h ...
http://www.scbt.com/ko/table-wapl.html...

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WAPL siRNA (h) sc-76910
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, WAPAL, 23063, 10q23.2, NM_015045 ...
http://www.scbt.com/ko/datasheet-76910-wapl-sirna-h.html...

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WAPL siRNA (m) sc-76911
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. マウス, Wapal, 218914, 14 B, Q65Z40 ...
http://www.scbt.com/ja/datasheet-76911-wapl-sirna-m.html...

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WAPL siRNA (m) sc-76911
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Wapal, 218914, 14 B, Q65Z40 ...
http://www.scbt.com/ko/datasheet-76911-wapl-sirna-m.html...

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WAPL (2H6) Antibody sc-135607
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, WAPAL, 23063,
10q23. ...
http://www.scbt.com/it/datasheet-135607-wapl-2h6-antibody.ht...

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