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FOXO1


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Symbol:FOXO1
Name(s):forkhead box O1
Type:protein-coding
Organism:Homo sapiens
Synonyms:FKH1, FKHR, FOXO1A
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18356527 findings define a conserved signaling link between Cdk1 and FOXO1 that may have a key role in diverse biological processes, including the degeneration of postmitotic neurons
17555999 A protective effect of FOXO1A haplotype on type 2 diabetes development.
17993506 FOXC1 regulates the expression of FOXO1A and binds to a conserved element in the FOXO1A promoter
15582274 Observational study of gene-disease association. (HuGE Navigator)
16497530 Observational study of gene-disease association. (HuGE Navigator)
16571842 Observational study of gene-disease association. (HuGE Navigator)
17555999 Observational study of gene-disease association. (HuGE Navigator)
17525748 developed a pathophysiologically relevant transcriptional profile of PAX3/FKHR and identified a critical target gene for aRMS development
17873969 FOXO1 transcript levels in RA patients and in SLE patients with active disease activity were significantly lower than those in normal controls, and the FOXO1 transcript levels were inversely correlated with lupus disease activity
17599040 FOXO1 serves as a tumor suppressor in endometrial cancer cells and is involved in normal growth control and maintenance of genomic stability.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAndrogen receptorforkhead box O1--Pubmed
HPRDandrogen receptor isoform 1FKHR--Pubmed
BINDHomo sapiens chromosome 6 genomic contig, reference assemblyforkhead box O1FoxO1 binds the distal region of the p21Cip1 promoter. This interaction was modelled on a demonstrated interaction between FoxO1 from an unspecified species and p21Cip1 promoter from an unspecified species.-Pubmed
HPRDCCAAT/enhancer binding protein betaforkhead box O1--Pubmed
HPRDCCAAT/enhancer binding protein betaforkhead box O1--Pubmed
HPRDCREBBPforkhead box O1--Pubmed
HPRDCREB binding proteinFKHR--Pubmed
BINDcatenin, beta 1, 88kDaforkhead box O1beta-catenin interacts with FOXO1. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human FOXO1.-Pubmed
HPRDestrogen receptor 1forkhead box O1--Pubmed
HPRDestrogen receptor 1forkhead box O1--Pubmed

Recent Publications on FOXO1:

Pubmed Logo
In this issue.
COVER IMAGE: This issue's cover features a composite of images showing...
3rd November, 2009
Eur J Immunol. 2009 Oct 30;39(11):2942-2943.
DOI Direct Link
PI3 Kinase Signals BCR-Dependent Mature B Cell Survival.
Previous work has shown that mature B cells depend upon survival signals...
3rd November, 2009
Program of Cellular and Molecular Medicine, Children's Hospital, and Cell. 2009 Oct 30;139(3):573-86.
DOI Direct Link
Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice.
Tumor necrosis factor alpha-converting enzyme (TACE, also known as ADAM17)...
31st October, 2009
Department of Internal Medicine, University of Rome Tor Vergata, Rome, Hepatology. 2009 Aug 25.
DOI Direct Link
Deletion of tumor necrosis factor-alpha-receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis.
In diet-induced obesity, hypothalamic and systemic inflammatory factors...
28th October, 2009
Univesity of Campinas, Brazil; J Biol Chem. 2009 Oct 26.
DOI Direct Link
Time Course Expression of Foxo Transcription Factors in Skeletal Muscle Following Corticosteroid Administration.
Increased expression of forkhead box O (Foxo) transcription factors were...
24th October, 2009
Cedars-Sinai Medical Center. J Appl Physiol. 2009 Oct 22.
DOI Direct Link

View more research publications.

Press Releases on FOXO1:

BioPortfolio Logo
Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged 10th September, 2008 Resveratrol Partners, LLC

SAN DIMAS, Calif., Sept. 10 /PRNewswire/ -- While the red wine molecule resveratrol (rez-vair-ah-trawl) has recently attracted scientific and public attention as a longevity molecule that

BioNews Results for FOXO1

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BioPortfolio Logo
Phosphorylation of Ser205 by the protein kinase CK2 persists on Pax3-FOXO1, but not Pax3, throughout early myo
Bioscience Technology Online:  Nov 13 2009 12:19PM Matching: foxo1
Foxo1 integrates insulin signaling with mitochondrial function in the liver
Nature Medicine:  Nov 5 2009 8:49PM Matching: foxo1
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
Nature Chemical Biology:  Oct 7 2009 7:30PM Matching: foxo1

Clinical Trials:

Clinical Trials Logo
Association Study of Genetic Polymorphisms of Candidate Genes With Thiazolidinedione-Related Peripheral Edema and Drug Responsiveness

Patents:

Patents logo
US Patent No.Title
7598348 Adiponectin receptor variant, AdipoR2v2
7592177 Compositions and methods for inducing cell dedifferentiation
7442515 Apparatus and methods for binding molecules and cells
7435808 Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
7371529 Methods and compositions for modulating gluconeogenesis using PGC-1

View more patents.

FOXO1 results (if any) from reagent suppliers

Google CSE Logo
FoxO1 (L27) Antibody #9454
FoxO1 (L27) Antibody detects endogenous levels of total FoxO1 protein and does not cross-react with endogenous FoxO3a or FoxO4. ...
http://www.cellsignal.com/products/9454.html...

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FOXO1 + FOXO3 + FOXO4 antibody (ab58518) | Abcam
Rabbit polyclonal to FOXO1 + FOXO3 + FOXO4. FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in ...
http://www.abcam.com/FOXO1-FOXO3-FOXO4-antibody-ab58518.html...

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Product Unavailable: FoxO1 Antibody #9462
We're sorry but the product you searched for: FoxO1 Antibody #9462 is no longer available. For more information about this product or alternative products, ...
http://www.cellsignal.com/products/9462.html...

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Anti-FOXO1 Polyclonal Antibody
Polyclonal Antibody against FOXO1 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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Phospho-FoxO1 (Ser319) Antibody #2486
Phospho-FoxO1 (Ser319) Antibody detects exogenous levels of FoxO1 only when phosphorylated at serine 319. The antibody does not cross-reacts with FoxO1 ...
http://www.cellsignal.com/products/2486.html...

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Anti-FOXO1 Polyclonal Antibody
Polyclonal Antibody against FOXO1 for use in Immunohistochemistry, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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Phospho-FoxO1 (Ser319)/FoxO4 (Ser262) Antibody #2487
Phospho-FoxO1 (Ser319)/FoxO4 (Ser262) Antibody detects exogenous levels of FoxO1 only when phosphorylated at serine 319 and exogenous levels of FoxO4 only ...
http://www.cellsignal.com/products/2487.html...

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