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JMJD2C


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Symbol:JMJD2C
Name(s):jumonji domain containing 2C
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ25949, GASC1, JHDM3C, KDM4C, KIAA0780, bA146B14.1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17611647 JMJD2C is the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis.
17277772 JMJD2C and LSD1 interact and both demethylases cooperatively stimulate androgen receptor-dependent gene transcription.
16732293 GASC1 interacts with H3K9me3; three members of this subfamily of proteins demethylate H3K9me3/me2 in vitro through a hydroxylation reaction requiring iron and alpha-ketoglutarate as cofactors

Recent Publications on JMJD2C:

Pubmed Logo
Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene.
Jmjd2c is a candidate oncogene that encodes histone lysine demethylase. In...
15th October, 2009
Division of Functional Genomics, Molecular & Cellular Targeting Biochem Biophys Res Commun. 2009 Nov 13;389(2):366-71. Epub 2009 Sep 2.
DOI Direct Link
The Histone Demethylase JMJD2C Is Stage-Specifically Expressed in Preimplantation Mouse Embryos and Is Required for Embryonic Development.
Epigenetic modifications play a pivotal role in embryonic development by...
22nd August, 2009
Biol Reprod. 2009 Aug 19.
DOI Direct Link
Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.
N-Oxalylglycine (NOG) derivatives were synthesized, and their inhibitory...
30th June, 2009
Nagoya City University, Tanabe-dori, Mizuho-ku, Aichi, Japan. Bioorg Med Chem Lett. 2009 May 15;19(10):2852-5. Epub 2009 Mar 26.
DOI Direct Link
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
The transcription factor HIF (hypoxia-inducible factor) mediates a highly...
31st January, 2009
Henry Wellcome Building for Molecular Physiology, University of Oxford, Biochem J. 2008 Dec 15;416(3):387-94.
DOI Direct Link
Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.
PURPOSE: The well-known translocations identified in MALT lymphomas...
17th December, 2008
Department of Pathology and Internal Medicine 1, Medical University of Clin Cancer Res. 2008 Oct 15;14(20):6426-31.
DOI Direct Link

View more research publications.

JMJD2C results (if any) from reagent suppliers

Google CSE Logo
JMJD2C Antibody Bethyl Laboratories
JMJD2C is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences ...
http://www.bethyl.com/product/A300-885A...

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KDM4C / GASC1 / JMJD2C antibody (ab27532) | Abcam
Rabbit polyclonal to KDM4C / GASC1 / JMJD2C. KDM4C / JMJD2C, a jumonji domain containing protein, is a histone demethylase. JMJD2C specifically demethylates
...
http://www.abcam.com/KDM4C-GASC1-JMJD2C-antibody-ab27532.htm...

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JMJD2B Antibody #2898
JMJD2A, JMJD2C and JMJD2D function as coactivators of the androgen receptor in ... JMJD2C, also known as GASC1, is amplified in squamous cell carcinomas and
...
http://www.cellsignal.com/products/2898.html...

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KDM4C / GASC1 / JMJD2C antibodies: Cancer > Oncoproteins ...
KDM4C / GASC1 / JMJD2C antibodies. ... KDM4C / GASC1 / JMJD2C antibody. Fast Track. Rabbit polyclonal. Predicted: Sc. ab45032 · KDM4C / GASC1 / JMJD2C ...
http://www.abcam.com/index.html?t=130822&pt=1&c=4334&ei=&mu=...

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JMJD Antibody / JMJD Antibodies
JMJD2C siRNA (h): sc-92765. JMJD2C shRNA Plasmid (h): sc-92765-SH. JMJD2C shRNA (h) ... JMJD2C shRNA (m) Lentiviral Particles: sc-146324-V ...
http://www.scbt.com/table-jmjd.html...

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GASC1 / JMJD2C peptide (ab30653) | Abcam
GASC1 / JMJD2C peptide. KDM4C / JMJD2C, a jumonji domain containing protein, is a histone demethylase. JMJD2C specifically demethylates Lysine 9 and Lysine ...
http://www.abcam.com/GASC1-JMJD2C-peptide-ab30653.html...

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JMJD2A (C70G6) Rabbit mAb
JMJD2A, JMJD2C and JMJD2D function as coactivators of the androgen receptor in prostate ... carcinoma, and inhibition of JMJD2C expression decreases ...
http://www.cellsignal.com/pdf/3393.pdf...

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