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FOXO3
| Symbol: | FOXO3 | | Name(s): | forkhead box O3 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AF6q21, DKFZp781A0677, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, MGC12739, MGC31925 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17959613 |
Despite potential for FOXO3 haploinsufficiency to cause ovarian failure, FOXO3 mutations or common SNPs are not common cause of either premature ovarian failure or primary amenorrhea. |
| 18178829 |
FOXO3a plays an important role in HIV-1-induced cell death of human macrophage. |
| 18055337 |
FKHRL1 siRNA underwent rapid apoptosis after erythropoietin (EPO) deprivation in the UT-7/EPO cells |
| 16571842 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17959613 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18032526 |
Suggest new pathway for the induction of oxidative stress by AGEs involving FKHRL1 inactivation and MnSOD suppression via Ser-36 phosphorylation of p66(shc) in human kidney cells. |
| 18063811 |
FOXO3a (forkhead box O3) increased the expression of MMP-3 (stromelysin-1) but decreased the expression of tissue inhibitors of metalloproteinases-1 (TIMP-1)in human umbilical vein endothelial cells |
| 18037997 |
activation of PKCtheta inhibits the FOXO3a/ERalpha/p27(Kip1) axis that normally maintains an epithelial cell phenotype and induces c-Rel target genes, thereby promoting proliferation, survival, and more invasive breast cancer. |
| 18032780 |
forkhead box O3 (FOXO3a) promotes apoptosis of endothelial cells through activation of c-Jun N-terminal kinase (JNK) and suppression of NF-kappaB |
| 17900262 |
FKHRL1 antagonized deregulates proliferation and induced apoptosis in myelogenous leukemia-derived cell lines. | →View more information from publications. |
Recent Publications on FOXO3: |  |
Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin.
OBJECTIVE: Oxidative stress induced by free fatty acids contributes to the... | 24th October, 2009
| Division of Cardiothoracic Surgery, Michael E. DeBakey Department of
| Diabetes. 2009 Oct;58(10):2246-57. Epub 2009 Jul 10.
DOI Direct Link |
Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.
OBJECTIVE: Atherosclerotic cardiovascular disease is the leading cause of... | 24th October, 2009
| Department of Medicine, College of Physicians and Surgeons of Columbia
| Diabetes. 2009 Oct;58(10):2344-54. Epub 2009 Jul 7.
DOI Direct Link |
Mechanisms Involved in 3',5'-Cyclic Adenosine Monophosphate-Mediated Inhibition of the Ubiquitin-Proteasome System in Skeletal Muscle.
Although it is well known that catecholamines inhibit skeletal muscle... | 20th October, 2009
| Departments of Physiology and Biochemistry & Immunology (D.A.P.G., E.C.L.,
| Endocrinology. 2009 Oct 16.
DOI Direct Link |
Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts.
Oxidative stress has been shown to induce apoptosis in a variety of... | 9th October, 2009
| Department of Biochemistry, University of Texas Health Science Center at
| Biochem Biophys Res Commun. 2009 Nov 6;389(1):117-21. Epub 2009 Aug 22.
DOI Direct Link |
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
Sirtuin 3 (SIRT3) is a member of the sirtuin family of proteins that... | 3rd October, 2009
| Department of Surgery, University of Chicago, Chicago, Illinois 60637,
| J Clin Invest. 2009 Sep;119(9):2758-71. doi: 10.1172/JCI39162. Epub 2009
DOI Direct Link |
→View more research publications. |
FOXO3 results (if any) from reagent suppliers | 
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Search Bioportfolio and other Life Science Sites for FOXO3,
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