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FLNA
| Symbol: | FLNA | | Name(s): | filamin A, alpha (actin binding protein 280) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ABP-280, ABPX, DKFZp434P031, FLN, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, filamin A | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17897634 |
in the absence of filamin A, chronic treatment with morphine, methadone or levorphanol leads to up-regulation of mu opioid receptor |
| 18056414 |
A library of FLNa fragments was generated to examine their F-actin binding to define the structural properties of FLNa that enable its various functions. |
| 17690686 |
analysis of filamin a IgFLN domains suggests that auto-inhibition by adjacent IgFLN domains may be a general mechanism controlling filamin-ligand interactions. |
| 17420725 |
FlnA restored Casodex anticaner sensitivity in C4-2 prostatic cancer cells by decreasing Akt phosphorylation. |
| 17536008 |
Essential for both the efficient signaling and sequestration of dopamine D3 receptor. |
| 17572668 |
Filamin-A as an adaptor protein that links HIV-1 receptors to the actin cytoskeleton remodelling machinery, which may facilitate virus infection. |
| 16030015 |
calmodulin and calcium regulate the binding of filamin A to actin filaments |
| 15668422 |
3 filamin A mutations were identified in periventricular heterotopia/Ehlers-Danlos patients: a 2762 delG, a C116 point mutation causing A39G, & a 4147 delG. |
| 15249610 |
Periventricular nodular heterotopia caused by FLN1 mutations in men has a wide clinical spectrum and is caused by different genetic mechanisms, including somatic mosaicism. |
| 12589795 |
PH domain of ROCK binds to the carboxy-terminal region of filamin-A containing the last 24th repeat. ROCK co-localized with filamin-A at the protrusive cell membranes of HeLa cells. | →View more information from publications. |
Recent Publications on FLNA: |  |
1H, 13C and 15N resonance assignments of the human filamin A tandem immunoglobulin-like domains 16-17 and 18-19.
Filamins are large actin-binding and cross-linking proteins which act as... | 29th October, 2009
| Laboratory of Organic Chemistry, Department of Chemistry, University of
| Biomol NMR Assign. 2009 Jun;3(1):53-6. Epub 2009 Jan 4.
DOI Direct Link |
Brainstem disconnection associated with nodular heterotopia and proatlantal arteries.
We report on a patient with brainstem disconnection associated with... | 21st October, 2009
| Department of Pediatrics, Juntendo University, School of Medicine, Tokyo,
| Am J Med Genet A. 2009 Oct 19;149A(11):2479-2483.
DOI Direct Link |
Aicardi syndrome in a male patient.
Aicardi syndrome ( OMIM 304050) is defined by the clinical triad of... | 17th October, 2009
| Department of Neuropaediatrics, Childrens Hospital,
| Neuropediatrics. 2009 Feb;40(1):39-42. Epub 2009 Jul 28.
DOI Direct Link |
Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension.
The physical properties of the extracellular matrix (ECM) regulate the... | 14th October, 2009
| Department of Pharmacology, University of Wisconsin, Madison, WI 53706,
| Mol Biol Cell. 2009 Jul;20(14):3224-38. Epub 2009 May 20.
DOI Direct Link |
Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer.
The cellular prion protein (PrP) is a highly conserved, widely expressed,... | 3rd October, 2009
| Department of Pathology, Case Western Reserve University, Cleveland, Ohio
| J Clin Invest. 2009 Sep;119(9):2725-36. doi: 10.1172/JCI39542. Epub 2009
DOI Direct Link |
→View more research publications. |
FLNA results (if any) from reagent suppliers | 
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Phospho-FLNA-S2151 Antibody
#AP3379a) and FLNA Non Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. ...
http://www.abgent.com/products/catalog_no/AP3379a_Phospho_FL...
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Filamin A Antibody Bethyl Laboratories
Alternate Names, FLN, FLNA, Filamin A, FLN1, Filamin 1, ABP280, ABP-280, actin- binding protein 280kDa, FMD, MNS, NHBP, OPD1, OPD2. Type, Polyclonal ...
http://www.bethyl.com/go/?product/A301-135A...
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FLNA Antibody (Y1046)
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with FLNA Antibody (Y1046) (Cat.#AP7770a), which was peroxidase-conjugated to the ...
http://www.abgent.com/products/catalog_no/AP7770a_FLNA_Antib...
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Filamin 1 (SPM182) Antibody sc-56392
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, FLNA, 2316, Xq28, NM_001456 · P21333
...
http://www.scbt.com/datasheet-56392-filamin-spm182-antibody....
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Abgent - Phosphospecific Antibody
AP3379a, Phospho-FLNA-S2151 Antibody, DB, E, H. AP3401a, Phospho-FLNA-S2522 Antibody, DB, E, H. AP3528a, Phospho-FLNA-pY1046 Antibody, DB, E, H ...
http://www.abgent.com/products/category/phosphospecific...
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Filamin A antibody (ab51217) | Abcam
Rabbit polyclonal to Filamin A. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton: ...
http://www.abcam.com/Filamin-A-antibody-ab51217.html...
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Abgent - Cell and Structure Antibodies - Cell_structure
AP7868aNEW, FKBP1B Antibody (N-term E6), WB, E, H, M. AP7868dNEW, FKBP1B Antibody (N-term), WB, E, H, M. AP7770a, FLNA Antibody (Y1046), IHC, E, H ...
http://www.abgent.com/products/category/cell_function/cell_s...
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