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FLNC
| Symbol: | FLNC | | Name(s): | filamin C, gamma (actin binding protein 280) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ABP-280, ABP280A, ABPA, ABPL, FLJ10186, FLN2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17825253 |
Taken together, our data suggest that p73alpha is sequestered in the cytoplasm by filamin A, thereby inhibiting its transcriptional activity. |
| 17412757 |
The mutant dimerization domain of filamin C is less stable and more susceptible to proteolysis. As a consequence, it does not dimerize properly and forms aggregates in vitro. |
| 17174070 |
These observations start to define the basis for PI3K regulation of filamin through LL5beta. |
| 15929027 |
a mutation in the dimerization domain of filamin c causes a novel type of autosomal dominant myofibrillar myopathy |
| 12480088 |
Accumulation is a strong but nonspecific immunohistochemical marker of core formation in muscle myopathies. |
| 17379241 |
The crystal structure of domain 23 of filamin C showed that the protein adopts the expected immunoglobulin (Ig)-like fold. A dimer is formed by domain 24; domain 23 has little interactions with itself or with domain 24. |
| 14506720 |
calpain 3 can cleave filamin C (FLNC); FLNC may be substrate for calpain 3, regulating protein-protein interactions with sarcoglycans |
| 15159586 |
gamma filamin has one molecule, with predominantly beta secondary-structure elements, per asymmetric unit |
| 15461588 |
results identify the muscle-specific isoform FLNc as a new physiological substrate for PKB |
Recent Publications on FLNC: |  |
Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication.
BACKGROUND: Helicobacter pylori (HP) infection potently induces aberrant... | 13th October, 2009
| Carcinogenesis Division, National Cancer Center Research Institute, 5-1-1
| J Gastroenterol. 2009 Oct 10.
DOI Direct Link |
In-frame deletion in the seventh immunoglobulin-like repeat of filamin C in a family with myofibrillar myopathy.
Myofibrillar myopathies (MFMs) are an expanding and increasingly... | 29th September, 2009
| National Institute of Neurological Disorders and Stroke, National
| Eur J Hum Genet. 2009 May;17(5):656-63. Epub 2008 Dec 3.
DOI Direct Link |
Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma.
Metastasis is a multi-step process involving many biomolecular changes and... | 12th August, 2009
| Department of Pathology, Seoul National University College of Medicine,
| Oncol Rep. 2009 May;21(5):1251-9.
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Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.
BACKGROUND: Mutations in filamin A (FLNa), an essential cytoskeletal... | 2nd July, 2009
| Translational Medicine Division, Department of Medicine, Brigham and
| PLoS One. 2009;4(3):e4928. Epub 2009 Mar 18.
DOI Direct Link |
Hypermethylation of genes for diagnosis and risk stratification of prostate cancer.
To identify the relevant CpG sites as molecular markers, for the diagnosis... | 19th June, 2009
| Department of Urology, Mayo Clinic/Foundation, Rochester, Minnesota 55905,
| Cancer Invest. 2009 Jun;27(5):549-60.
DOI Direct Link |
→View more research publications. |
FLNC results (if any) from reagent suppliers | 
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Trio (D-20) Antibody sc-6060
Loss of FilaminC (FLNc) Results in Severe Defects in Myogenesis and Myotube Structure. Mol. Cell. Biol. 26(17): 6522-6534. View PubMed Entry ...
http://www.scbt.com/datasheet-6060-trio-d-20-antibody.html...
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Integrin beta 1 antibody, Integrin beta 1 [4B7] Antibody, Mouse ...
Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with HIV-1 Tat. ...
http://www.genwaybio.com/product_info.php?products_id=191968...
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Filamin Antibody / Filamin Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. Filamin 1 (E-3) Antibody, sc-17749, mouse IgG2a, N-terminus (h), WB, IP, IF, IHC(P), ELISA ...
http://www.scbt.com/ko/table-filamin.html...
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Abcam antibodies and reagents product map
... FLNB antibodies (2) · FLNC antibodies (1) · Fascin 2 antibodies (1) · Filamin A antibodies (10) · Kettin antibodies (1) · Myotilin antibodies (3) ...
http://www.abcam.com/index.html?c=2105...
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Filamin Antibody / Filamin Antibodies
製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. Filamin 1 (E-3) 抗体, sc-17749, mouse IgG2a, N-terminus (h), WB, IP, IF, IHC(P),
...
http://www.scbt.com/ja/table-filamin.html...
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Integrin
ACTA2 (Actin α2), DNM1 (Dynamin), LMNA (Lamin A), TLN (Talin). ACTB (Actin β), FLNC (Filamin C), LMNB1 (Lamin B1), TUBA1A (Tubulin) ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...
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Filamin 2 (K-18) Antibody sc-48496
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, FLNC, 2318, 7q32.
1 ...
http://www.scbt.com/it/datasheet-48496-filamin-2-k-18-antibo...
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