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FLT1
| Symbol: | FLT1 | | Name(s): | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FLT, VEGFR1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17975225 |
lineage-negative, CD34-negative (Lin(-)CD34(-)) multipotent mesenchymal stromal cells express vascular endothelial growth factor receptor-1 (VEGFR-1), which mediates their response to vascular endothelial growth factor A |
| 18315732 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18287964 |
FLT-1 mRNA levels were uniformly increased in congenital hemangiomas compared with proliferating or involuting phase common hemangioma. |
| 17964871 |
G-CSF treatment induced reduced expression of CXCR4, VLA-4 and VEGFR-1 in patients with liver failure. |
| 17891484 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17956952 |
Preeclampsia trophoblast cells produce more sEng, sFlt-1, and PlGF than normal TCs. Lowered oxygen conditions promote sEng and sFlt-1, but reduce PlGF, productions by PE TCs. |
| 17956955 |
Reduced placental perfusion may contribute to the increased expression of sFlt-1 in IUGR pregnancies. Data are compatible with differential sFlt-1 expression in placentas from discordant twins. |
| 18079407 |
Both PlGF-1 (placenta growth factor) and VEGF-A (vascular endothelial growth factor-A ) can activate VEGFR-1-(vascular endothelial growth factor receptor-1)dependent signaling pathways in primary human monocytes |
| 18097592 |
VEGFR-1 expression is not associated with the risk of cancer progression following RP. Therefore, VEGFR-1 may not be of prognostic value in clinically-localized PCa. |
| 17982238 |
sFlt-1 and PlGF and their ratio relative to one another may play a role in the development of preeclampsia | →View more information from publications. |
Recent Publications on FLT1: |  |
Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration.
Although vascular endothelial growth factor-B (VEGF-B) is a homolog of the... | 31st October, 2008
| Vesalius Research Center, Katholieke Universiteit Leuven, Leuven B-3000,
| J Neurosci. 2008 Oct 15;28(42):10451-9.
DOI Direct Link |
First-trimester serum levels of soluble endoglin and soluble fms-like tyrosine kinase-1 as first-trimester markers for late-onset preeclampsia.
OBJECTIVE: The aim of this investigation was to assess soluble endoglin... | 31st October, 2008
| Department of Obstetrics and Gynecology, Inselspital, Bern University
| Am J Obstet Gynecol. 2008 Sep;199(3):266.e1-6.
DOI Direct Link |
Impact of VEGF and VEGF receptor 1 (FLT1) expression on the prognosis of stage III esophageal cancer patients after radiochemotherapy.
BACKGROUND AND PURPOSE: High expression of vascular endothelial growth... | 30th October, 2008
| Department of Radiation Oncology, University Medical Center
| Strahlenther Onkol. 2008 Aug;184(8):416-20.
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Flt1, pregnancy, and malaria: evolution of a complex interaction.
Pre-eclampsia is a pregnancy related condition characterised by... | 23rd October, 2008
| Department of Medicine, Beth Israel Deaconess Medical Center and Harvard
| Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14243-4. Epub 2008 Sep 18.
DOI Direct Link |
Natural selection of FLT1 alleles and their association with malaria resistance in utero.
Placental malaria (PM) caused by Plasmodium falciparum contributes... | 23rd October, 2008
| Mother-Offspring Malaria Studies Project, Seattle Biomedical Research
| Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14488-91. Epub 2008 Sep 8.
DOI Direct Link |
→View more research publications. |
FLT1 results (if any) from reagent suppliers | 
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