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JMJD6

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Symbol:	JMJD6
Name(s):	jumonji domain containing 6
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	KIAA0585, PSR, PTDSR, PTDSR1
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
17534701	Homomultimer of PS-R might be playing an important function as a scaffolding protein in the nucleus.
17947579	study demonstrates that JMJD6 is a JmjC-containing iron- and 2-oxoglutarate-dependent dioxygenase that demethylates histone H3 at arginine 2 (H3R2) and histone H4 at arginine 3 (H4R3) in both biochemical and cell-based assays
11877474	Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis.
15072554	plays a major role in the clearance of apoptotic cells from the thymus.
15345036	The mouse ortholog of Ptdsr is essential for the development and differentiation of multiple organs during embryogenesis but not for apoptotic cell clearance.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
BIND	dedicator of cytokinesis 1	KIAA0585 protein	PSR interacts with DOCK180. This interaction was modelled on a demonstrated interaction between PSR from human and CED-5 from Caenorhabditis elegans.	-	Pubmed
BIND	engulfment and cell motility 1 isoform 1	KIAA0585 protein	PSR interacts with ELMO1. This interaction was modelled on a demonstrated interaction between PSR from human and CED-12 from Caenorhabditis elegans.	-	Pubmed

Recent Publications on JMJD6:
Endogenous Jmjd6 gene product is expressed at the cell surface and regulates phagocytosis in immature monocyte-like activated THP-1 cells. A jumonji domain containing gene 6 (Jmjd6), previously referred to as...	29th August, 2009	Department of Physiology and Membrane Biology, University of California,	J Cell Physiol. 2009 Oct;221(1):84-91. DOI Direct Link
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. The finding that the metazoan hypoxic response is regulated by...	16th July, 2009	Chemistry Research Laboratory and Oxford Centre for Integrative Systems	Science. 2009 Jul 3;325(5936):90-3. DOI Direct Link
Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins. BACKGROUND: The jumonji C (JmjC) domain containing gene 6 (Jmjd6,...	29th July, 2008	Research Group Infection Genetics, Department of Experimental Mouse	BMC Genomics. 2008 Jun 18;9:293. DOI Direct Link
JMJD6 is a histone arginine demethylase. Arginine methylation occurs on a number of proteins involved in a variety...	6th November, 2007	Department of Biochemistry, University of Texas Southwestern Medical	Science. 2007 Oct 19;318(5849):444-7. DOI Direct Link
Molecular biology. Unlocking cell fate. Arginine methylation occurs on a number of proteins involved in a variety...	6th November, 2007	Department of Biochemistry and Biophysics, UNC Lineberger Comprehensive	Science. 2007 Oct 19;318(5849):403-4. DOI Direct Link
→View more research publications.

Clinical Trials:
PSRand MFG-E8 Polymorphism in RA and SLE

JMJD6 results (if any) from reagent suppliers

JMJD6 antibody (ab10526) \| Abcam Rabbit polyclonal to JMJD6. JMJD6 (PSR / PTDSR) is required during embryogenesis and differentiation of multiple organs during embryogenesis. http://www.abcam.com/JMJD6-antibody-ab10526.html...
JMJD6 (PTDSR) Antibody (C-term) JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Protein PTDSR; Jmjd6; Ptdsr;. Application Data: Calculated MW: 46540 Da ... http://www.abgent.com/products/catalog_no/AP1042b_JMJD6_PTDS...
JMJD6 proteins and peptides: Developmental Biology > Embryogenesis ... JMJD6 proteins and peptides. ... JMJD6 proteins and peptides. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication ... http://www.abcam.com/index.html?t=58631&pt=2&c=4600&ei=&mu=r...
Protein Modification - Methylation Antibody AP1031b, JMJD5 Antibody (C-term), WB, E, H, M. AP1042b, JMJD6 (PTDSR) Antibody ( C-term), WB, E, H. AP1042a, JMJD6 (PTDSR) Antibody (N-term), WB, E, H, M ... http://www.abgent.com/products/category/protein_modification...
Antibodies to Other Apoptosis-related Proteins human ... JMJD6(23210) mouse ... Jmjd6(107817), mouse, human, ARR, IP, WB, pricing. R9650, Anti-RICK, C-Terminal antibody produced in rabbit, (polyclonal) ... http://www.sigmaaldrich.com/etc/controller/controller-page.h...
PSR (N-20) Antibody sc-11632 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, JMJD6, 23210, 17q25.2, NM_015167 ... http://www.scbt.com/datasheet-11632-psr-n-20-antibody.html...
P1495 Anti-Phosphatidylserine Receptor antibody produced in rabbit ... microarray: suitable. Gene Information, human ... JMJD6(23210). mouse ... Jmjd6( 107817). shipped in, dry ice. storage temp. −20°C ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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JMJD6

Gene Information from Publications

Interacting gene products

Recent Publications on JMJD6:

Clinical Trials:

JMJD6 results (if any) from reagent suppliers