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PACS2


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Symbol:PACS2
Name(s):phosphofurin acidic cluster sorting protein 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ25488, KIAA0602, PACS1L
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15692563 subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2
15692567 PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDBH3 interacting domain death agonist isoform 2phosphofurin acidic cluster sorting protein 2PACS2 interacts with BID.-Pubmed
BINDpolycystin 2phosphofurin acidic cluster sorting protein 2PACS-2 interacts with PKD2.-Pubmed

Recent Publications on PACS2:

Pubmed Logo
At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.
The endomembrane system in mammalian cells has evolved over the past two...
16th July, 2009
Vollum Institute, Oregon Health and Science University, 3181 SW Sam Biochem J. 2009 Jun 12;421(1):1-15.
DOI Direct Link
Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.
TRAIL selectively kills diseased cells in vivo, spurring interest in this...
26th June, 2009
Vollum Institute, Oregon Health & Science University, Portland, OR 97239, Mol Cell. 2009 May 14;34(4):497-509.
DOI Direct Link
The subcellular distribution of calnexin is mediated by PACS-2.
Calnexin is an endoplasmic reticulum (ER) lectin that mediates protein...
26th February, 2009
Department of Cell Biology, University of Alberta, Edmonton, Alberta, Mol Biol Cell. 2008 Jul;19(7):2777-88. Epub 2008 Apr 16.
DOI Direct Link
HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.
Human immunodeficiency virus, type 1, negative factor (Nef) initiates...
20th June, 2008
Vollum Institute, Portland, Oregon 97239, USA. J Biol Chem. 2008 Apr 25;283(17):11772-84. Epub 2008 Feb 22.
DOI Direct Link
In silico comparison of pKLC102-like genomic islands of Pseudomonas aeruginosa.
The genomic island pKLC102 first detected in Pseudomonas aeruginosa clone...
7th December, 2007
Klinische Forschergruppe, OE 6711, Medizinische Hochschule Hannover, FEMS Microbiol Lett. 2007 Oct;275(2):244-9. Epub 2007 Aug 22.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7230161 Engineering single-gene-controlled staygreen potential into plants utilizing ACC synthase from maize
6458934 Humanized antibody specific for human 4-1BB

PACS2 results (if any) from reagent suppliers

Google CSE Logo
PACS-2 siRNA (m) sc-151987
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: PACS-2 ...
http://www.scbt.com/datasheet-151987-pacs-2-sirna-m.html...

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FACL4 antibody (ab38420) | Abcam
PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid- mediated apoptosis. EMBO J 24:717-29 (2005). PubMed: 15692567 ...
http://www.abcam.com/FACL4-antibody-ab38420.html...

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PACS Antibody / PACS Antibodies
PACS-2 siRNA (h): sc-92426. PACS-2 shRNA Plasmid (h): sc-92426-SH. PACS-2 shRNA (h) ... PACS-2 shRNA (m) Lentiviral Particles: sc-151987-V ...
http://www.scbt.com/table-pacs.html...

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KDM4A / JHDM3A / JMJD2A antibody - ChIP Grade (ab24545) | Abcam
Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Mol Cell 34:497-509 (2009). ChIP; Human.
...
http://www.abcam.com/KDM4A-JHDM3A-JMJD2A-antibody-ChIP-Grade...

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P1-PC
HPA001423, Anti-PACS2 antibody produced in rabbit, (polyclonal), affinity isolated antibody, human ... PACS2(23241), human, IHC (p), PA, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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