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ICOSLG
| Symbol: | ICOSLG | | Name(s): | inducible T-cell co-stimulator ligand | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, KIAA0653, LICOS | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12707012 |
These results demonstrate that airway epithelial cells express the costimulatory molecule B7-H2, and suggest the possibility that B7-H2 may participate in antigen presentation by epithelial cells. |
| 16221208 |
Interaction of tubular epithelial cells and kidney infiltrating T cells via ICOS-L and B7-H1 may change the balance of positive and negative signals to the T cells |
| 12800259 |
ICOS-B7H costimulatory pathway may be involved in the negative regulation of cell-mediated immune responses. |
| 12456022 |
ICOS-L is a ligand for ICOS and plays an important functional role in the activation of memory T cells by endothelial cells [review] |
| 15047568 |
Expression of B7-H3 by nasal epithelial. Expands range of potential costimulatory signals through which these cells may interact with activated mucosal T lymphocytes. Extent of mucociliary differentiation of cultured cells may influence this capability. |
| 12960306 |
A critical role of the B7-like protein-ICOS costimulatory pathway is demonstrated in the pathogenesis of lupus nephritis. |
| 14603470 |
ICOSL protein and mRNA was expressed in 7 of 12 glioma cell lines and expression is upregulated by the inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), whereas interferon-gamma (IFN-gamma) has no such effect |
| 17242332 |
ICOS-L may be relevant in inducing an acute immune response and may be critically involved in perpetuating inflammation in chronically immune-mediated disorders of the peripheral nervous system. |
| 16115907 |
Results indicate the expression of functional B7-H2 molecule may facilitate progression of acute myeloid leukemia. |
| 15131796 |
B7h-ICOS protein costimulatory pathway may be important in intestinal epithelial cell(iec):T-cell interactions. IEC expressed B7h and B7-H1. | →View more information from publications. |
Recent Publications on ICOSLG: |  |
The genetics of Crohn's disease.
From epidemiological data, based on concordance data in family studies,... | 14th October, 2009
| Department of Pediatric Gastroenterology and Nutrition, Royal Hospital for
| Annu Rev Genomics Hum Genet. 2009;10:89-116.
DOI Direct Link |
Increased expression of soluble inducible costimulator ligand (ICOSL) in patients with systemic lupus erythematosus.
To investigate the level of costimulating molecules in systemic lupus... | 16th September, 2009
| Division of Rheumatology, Department of Internal Medicine, Pusan Paik
| Lupus. 2009 May;18(6):501-7.
DOI Direct Link |
The role of costimulation in antibody deficiencies: ICOS and common variable immunodeficiency.
SUMMARY: The identification of mutations in the inducible costimulator... | 18th July, 2009
| Department of Clinical Immunology, Kings College Hospital, London, UK.
| Immunol Rev. 2009 May;229(1):101-13.
DOI Direct Link |
Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage.
PURPOSE: B7 family molecules expressed on antigen-presenting cells... | 17th July, 2009
| Division of Hematology, Department of Medicine, Nippon Medical School,
| Clin Cancer Res. 2009 Feb 1;15(3):770-7.
DOI Direct Link |
Interaction of T-cell and antigen presenting-cell co-stimulatory genes in childhood IgE.
It is likely that multiple genes contribute to IgE production.... | 4th July, 2009
| University Medical Center Groningen, University of Groningen, Groningen,
| Eur Respir J. 2009 Jul 2.
DOI Direct Link |
→View more research publications. |
ICOSLG results (if any) from reagent suppliers | 
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B7RP-1 (GM-13C1) Antibody sc-59263
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ICOSLG, 23308, 21q22.3, NM_015259 ...
http://www.scbt.com/datasheet-59263-b7rp-1-gm-13c1-antibody....
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B7RP-1 (2D3) Antibody sc-53652
... Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, ICOSLG, 23308, 21q22.3, NM_015259 · O75144 ...
http://www.scbt.com/it/datasheet-53652-b7rp-1-2d3-antibody.h...
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