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SIRT1
| Symbol: | SIRT1 | | Name(s): | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | SIR2L1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18329615 |
These results support a model where the normal function of SIRT1 as a negative regulator of T cell activation is suppressed by Tat during HIV infection. |
| 18230337 |
Our results indicate that nicotinamide treatment attenuates p21WAF1 expression through Sp1 downregulation, and suggest a possible involvement of nicotinamide metabolism in cellular gene expression. |
| 16257164 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17373700 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17895433 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17996922 |
SIRT1 protein may be functionally associated with WRN and BLM helicases and that some major SIRT1 functions may not require its deacetylase activity. |
| 18235501 |
DBC1 directly interacts with SIRT1 and inhibits SIRT1 activity in vitro and in vivo |
| 18235502 |
DBC1 (deleted in breast cancer 1) acts as a native inhibitor of SIRT1 in human cells |
| 17937892 |
Activation of the SIRT1/PGC-1 pathway, in a metabolic context promotes mitochondrial function and this pathway plays a role in neurodegerative disease. Review. |
| 17901049 |
possible regulatory effect of SirT1 on insulin-induced tyrosine phosphorylation of IRS-2, a vital step in insulin signaling pathway, through deacetylation of IRS-2 protein. | →View more information from publications. |
Recent Publications on SIRT1: |  |
Epigenetic modifications induced by RGC-32 in colon cancer.
First described as a cell cycle activator, RGC-32 is both an activator and... | 4th November, 2009
| Department of Neurology, University of Maryland School of Medicine,
| Exp Mol Pathol. 2009 Oct 30.
DOI Direct Link |
FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States.
The nuclear bile acid receptor FXR is critical for regulation of lipid and... | 4th November, 2009
| Department of Molecular and Integrative Physiology, University of
| Cell Metab. 2009 Nov 4;10(5):392-404.
DOI Direct Link |
SIRT1-dependent Regulation of Chromatin and Transcription: Linking NAD(+) Metabolism and Signaling to the Control of Cellular Functions.
Sirtuins comprise a family of NAD(+)-dependent protein deacetylases and... | 3rd November, 2009
| Department of Molecular Biology and Genetics, Cornell University, Ithaca,
| Biochim Biophys Acta. 2009 Oct 29.
DOI Direct Link |
Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.
Increasing evidence suggests that a restricted caloric intake extends the... | 31st October, 2009
| Department of Endocrinology, Changzhou no.2 People's Hospital, Nanjing
| Acta Diabetol. 2009 Oct 30.
DOI Direct Link |
Early life nutrition influences thymic growth in male mice that may be related to the regulation of longevity.
Nutrition and growth rate during early life can influence later health and... | 31st October, 2009
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| Clin Sci (Lond). 2009 Oct 29.
DOI Direct Link |
→View more research publications. |
Press Releases on SIRT1:
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| Researchers Report Combined Molecules in Red Wine by Far Exceed the Biological Activity of Plain Resveratrol, Consistent With the Composition of Longevinex(R) |
10th March, 2009 |
Longevinex |
SAN DIMAS, Calif., March 10 /PRNewswire/ -- A recent CBS 60 Minutes TV program drew considerable attention to resveratrol (rez-vair-ah-trawl), a red wine molecule believed to largely be responsible
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| Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged |
10th September, 2008 |
Resveratrol Partners, LLC |
SAN DIMAS, Calif., Sept. 10 /PRNewswire/ -- While the red wine molecule
resveratrol (rez-vair-ah-trawl) has recently attracted scientific and public
attention as a longevity molecule that
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SIRT1 results (if any) from reagent suppliers | 
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