Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18329615 |
These results support a model where the normal function of SIRT1 as a negative regulator of T cell activation is suppressed by Tat during HIV infection. |
| 18230337 |
Our results indicate that nicotinamide treatment attenuates p21WAF1 expression through Sp1 downregulation, and suggest a possible involvement of nicotinamide metabolism in cellular gene expression. |
| 16257164 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17373700 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17895433 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17996922 |
SIRT1 protein may be functionally associated with WRN and BLM helicases and that some major SIRT1 functions may not require its deacetylase activity. |
| 18235501 |
DBC1 directly interacts with SIRT1 and inhibits SIRT1 activity in vitro and in vivo |
| 18235502 |
DBC1 (deleted in breast cancer 1) acts as a native inhibitor of SIRT1 in human cells |
| 17937892 |
Activation of the SIRT1/PGC-1 pathway, in a metabolic context promotes mitochondrial function and this pathway plays a role in neurodegerative disease. Review. |
| 17901049 |
possible regulatory effect of SirT1 on insulin-induced tyrosine phosphorylation of IRS-2, a vital step in insulin signaling pathway, through deacetylation of IRS-2 protein. |
| 17916362 |
Sirt1 exerts a protective effects against endothelial dysfunction by preventing stress-induced premature senescence. |
| 17964266 |
Active regulator of SIRT1 (AROS) is the first direct SIRT1 regulator to be identified that modulates p53-mediated growth regulation. |
| 17806102 |
Data show that SIRT1 is highly expressed in cancer cell lines as well as in tissue samples from colon carcinoma patients. |
| 17934453 |
A novel post-translational sumoylation of SIRT1 at Lys734 increased its deacetylase activity. Stress-inducing agents promoted association of SIRT1 with SENP1 and cells depleted of SENP1 were more resistant to stress-induced apoptosis. |
| 17680780 |
interaction between Sirt1 and TLE1 is important for mediating repression of NF-kappaB activity |
| 17581637 |
SIRT1 constitutes a unique molecular link between aging and human neurodegenerative disorders and provides a promising avenue for therapeutic intervention |
| 17785417 |
SIRT1 promotes endothelium-dependent vascular relaxation by activating eNOS. |
| 17895433 |
SIRT1 haplotypes were assessed for association with the risks of mortality, metabolic profile, age-related diseases, and cognitive functioning. These analyses revealed a trend for lower cardiovascular mortality for haplotype 2 and rs3758391 SNP carriers. |
| 17516504 |
SIRT1 was distributed in cytoplasm at metaphase during mitosis, and overexpression of SIRT1 significantly augmented apoptosis for cells at metaphase. |
| 17505061 |
Corepressor of androgen receptor, elucidating a new pathway relevant to prostate cancer growth and approaches to therapy. |
| 17180656 |
Overexpression of SIRT1 may have some relevance to the early stage of skin carcinogenesis. |
| 15152190 |
provides evidence that SIRT1 activity augments apoptosis in response to TNFalpha by the ability of the deacetylase to inhibit the transactivation potential of the RelA/p65 protein |
| 12297502 |
Data show that physiological concentrations of nicotinamide noncompetitively inhibit SIRT1 in vitro. |
| 15692560 |
FHL2 inhibits FOXO1 activity in prostate cancer cells by promoting the deacetylation of FOXO1 by SIRT1 |
| 16923962 |
evidence for an androgen receptor (AR) regulatory pathway controlled by SIRT1; SIRT1 antagonists induce endogenous AR expression and enhance dihydrotestosterone-mediated AR expression |
| 14980222 |
SIRT1 represses forkhead transcription factors and reduces apoptosis |
| 17638871 |
SIRT1 is significantly elevated in mouse and human prostate cancer |
| 12930829 |
SIRT1 is a histone H3/H4 deacetylase in mammalian cells and in transcriptional repression mediated by CTIP2 |
| 15719057 |
Hiv Tat is deacetylated by human sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent class III protein deacetylase in vitro and in vivo |
| 16751189 |
expression of SIRT1 in the brain resulted in decreased ROCK1 expression and elevated alpha-secretase activity; SIRT1 activation in the brain is a novel mechanism through which calorie restriction may influence Alzheimer disease amyloid neuropathology |
| 14976264 |
SIRT1 and FOXO3 formed a complex in cells in response to oxidative stress; SIRT1 deacetylated FOXO3; SIRT1 increased FOXO3's ability to induce cell cycle arrest and resistance to oxidative stress but inhibited FOXO3's ability to induce cell death |
| 12535671 |
These results indicate that the molecular association between HES1-, HEY2- and SIRT1-related proteins is conserved among metazoans, from Drosophila to human, and suggest that the Sir2-bHLH interaction also plays important roles in human cells. |
| 16328012 |
Data describe the cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1.( |
| 15749705 |
binding of resveratrol to SIRT1 promotes a conformational change that accommodates the attached coumarin group |
| 17112576 |
The association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis. |
| 17213307 |
propose that the reduction in transcriptional repression mediated by hypermethylated in cancer 1, due to the decrease of CtBP binding, increases SIRT1 expression |
| 15632193 |
SIRT1 deacetylation and repression of p300 involves specific lysine residues in the cell cycle regulatory domain 1 |
| 16166628 |
histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications regulate MEF2 |
| 16354677 |
Although SIRT1 deacetylates p53, this does not play a role in cell survival following DNA damage in certain cell lines and primary human mammary epithelial cells. |
| 16628003 |
AIF-mediated cell death is regulated by the functional interplay of SIRT1 and PARP-1 in response to DNA damage |
| 15639232 |
SIRT1 has a role in transcriptional repression mediated by BCL11A in mammalian cells |
| 15640142 |
substrate recognition by SIRT1 does not depend on the amino acid sequence proximate to the acetylated lysine |
| 12006491 |
the SIRT1 deacetylase as a novel negative regulator of p53 function capable of modulating cellular senescence |
| 16183991 |
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling |
| 16288004 |
Overexpression of sirt1 induced expression of P-glycoprotein and rendered cancer cells resistant to doxorubicin. |
| 17041012 |
These data show that SIRT1 regulates cigarette smoke-mediated proinflammatory mediator release via NF-kappaB, implicating a role of SIRT1 in sustained inflammation and aging of the lungs. |
| 16892051 |
There is a mutual regulation between E2F1 and SirT1 that affects cellular sensitivity to DNA damage. |
| 16998810 |
SIRT1 can modulate p73 activity via deacetylation. |
| 17099246 |
In contrast, a SIRT1 inhibitory compound showed a stimulatory activity on the differentiation of adipocytes, a feature often linked to insulin sensitization. |
| 17317627 |
HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes. |
| 17612497 |
Deacetylation of NBS1 by SIRT1 plays a key role in the dynamic regulation of the DNA damage response and in the maintenance of genomic stability. |
| 15126506 |
Data demonstrate that acetylation functions in a second pathway of negative control for FOXO factors and provides a novel mechanism whereby hSir2(SIRT1) can promote cellular survival and increase lifespan. |
| 16207712 |
PARP activation and the concomitant reduction of Sir2alpha activity in failing hearts regulate the post-translational acetylation of p53 |
| 17283066 |
HIC1 is a target of the class III deacetylase SIRT1 and identify a new posttranslational modification step in the P53-HIC1-SIRT1 regulatory loop. |
| 17334224 |
SIRT1 modulates DNA repair activity, which could be regulated by the acetylation status of repair protein Ku70 following DNA damage |
| 15205477 |
SIRT1 deacetylates the DNA repair factor Ku70, causing it to sequester the proapoptotic factor Bax away from mitochondria, thereby inhibiting stress-induced apoptotic cell death |
| 17041012 |
SIRT1 regulates cigarette smoke induced pro-inflammatory mediators release via RelA/p65 NF-{kappa}B in macrophages. |
| 11672522 |
SIRT1(Sir2alpha) deacetylates p53 and promotes survival |
