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ICMT
| Symbol: | ICMT | | Name(s): | isoprenylcysteine carboxyl methyltransferase | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | HSTE14, MGC39955, MST098, MSTP098, PCCMT, PCMT, PPMT | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 14966563 |
These studies identify isoprenylcysteine carboxyl methyltransferase as a potential target for reducing the growth of K-Ras- and B-Raf-induced malignancies. |
| 12006387 |
ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway and appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1 in endothelial cells. |
| 11906819 |
modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma cells |
| 17347446 |
ICMT inhibition induces endothelial cell apoptosis through GRP94 |
| 12631708 |
findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase methylation and activation and its downstream antiapoptotic signaling pathway. |
Recent Publications on ICMT: |  |
Caenorhabditisis a metazoan host for Legionella.
Abstract We investigated whether nematodes contribute to the persistence,... | 30th October, 2009
| Division of Infectious Diseases and International Health, Department of
| Cell Microbiol. 2009 Oct 27.
DOI Direct Link |
Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.
Laminopathies are rare monogenic diseases, some of them exhibiting... | 21st October, 2009
| INSERM, UMR_S 937, 75013, Paris, France.
| J Mol Med. 2009 Oct 16.
DOI Direct Link |
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly... | 20th October, 2009
| Curriculum in Genetics and Molecular Biology, University of North Carolina
| Oncogene. 2009 Oct 19.
DOI Direct Link |
Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide.
Of the molecular biochemical alterations that occur during apoptosis,... | 7th October, 2009
| Comprehensive Cancer Imaging Center, Department of Oncology, Imperial
| Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16375-80. Epub 2009 Sep 3.
DOI Direct Link |
Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.
A number of proteins that play key roles in biological regulatory events... | 5th August, 2009
| Department of Pharmacology and Cancer Biology, Duke University Medical
| J Biol Chem. 2009 Oct 9;284(41):27964-73. Epub 2009 Aug 3.
DOI Direct Link |
→View more research publications. |
ICMT results (if any) from reagent suppliers | 
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ICMT Antibody / ICMT Antibodies
ICMT Antibody / ICMT Antibodies. ... ICMT specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-icmt.html...
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ICMT (C-term) Antibody
The anti-ICMT Pab (Cat. #AP2543b) is used in Western blot to detect ICMT in T47D (left) and SK-BR-3 (right) tissue lysate ...
http://www.abgent.com/products/catalog_no/AP2543b_ICMT_C_ter...
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ICMT siRNA (h) sc-88830
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: ICMT ...
http://www.scbt.com/de/datasheet-88830-icmt-sirna-h.html...
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Protein Modification - Methylation Antibody
AT2406aNEW, HOXA5 monoclonal antibody (M09), ELISA,S-ELISA,WB-Re, H. AP1020b, HSPBAP1 Antibody (C-term), WB, E, H. AP2543b, ICMT (C-term) Antibody, WB, E, H
...
http://www.abgent.com/products/category/protein_modification...
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ICMT Antibody / ICMT Antibodies
ICMT Antibody / ICMT Antibodies. ... ICMT specific siRNA, sHRNA Plasmid과 shRNA Lentiviral Particles gene silencers 도 제공합니다. ...
http://www.scbt.com/ko/table-icmt.html...
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Abgent - Translation and Regulation Antibodies ...
AP8064c, Haspin GSG2 Antibody (Center), IHC, E, H. AP2543b, ICMT (C-term) Antibody, WB, E, H. AP2543a, ICMT (N-term) Antibody, E, H ...
http://www.abgent.com/products/category/nuclear_signaling/tr...
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ICMT (C-21) Antibody sc-130150
rabbit polyclonal IgG, 100µg/ml; recommended for detection of ICMT of human ... Western blot analysis of ICMT expression in T4D7D (A) and SK-BR-3 whole cell ...
http://www.scbt.com/ko/datasheet-130150-icmt-c-21-antibody.h...
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