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PADI4


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Symbol:PADI4
Name(s):peptidyl arginine deiminase, type IV
Type:protein-coding
Organism:Homo sapiens
Synonyms:PAD, PAD4, PADI5, PDI4, PDI5
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15077293 Observational study of gene-disease association. (HuGE Navigator)
15338034 Observational study of genotype prevalence. (HuGE Navigator)
15731287 Observational study of gene-disease association. (HuGE Navigator)
15814578 Observational study of gene-disease association. (HuGE Navigator)
15883854 Observational study of genotype prevalence. (HuGE Navigator)
15998632 Observational study of gene-disease association. (HuGE Navigator)
16200584 Observational study of gene-disease association. (HuGE Navigator)
16380915 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
16385500 Observational study of gene-disease association. (HuGE Navigator)
16449362 Meta-analysis of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHomo sapiens chromosome 21, reference assembly.peptidyl arginine deiminase, type IVPAD4 interacts with the pS2 promoter.-Pubmed
BINDHomo sapiens chromosome 21 genomic contig, alternate assemblypeptidyl arginine deiminase, type IVPADI4 interacts with pS2.-Pubmed
BINDhistone cluster 3, H3peptidyl arginine deiminase, type IVPAD4 interacts with and demethyliminates Histone H3.-Pubmed
BINDpeptidyl arginine deiminase, type IVhistone cluster 4, H4PAD4 interacts with and demethyliminates Histone H4.-Pubmed

Recent Publications on PADI4:

Pubmed Logo
[Influence of genetic factors on development and severity of rheumatoid arthritis--part I]
Both genetic and environmental factors affect susceptibility, severity and...
28th October, 2009
Institute of Rheumatology in Warsaw, Department of Systemic Connective Pol Merkur Lekarski. 2009 Aug;27(158):157-60.
Regulation of Protein Citrullination through p53/PADI4 Network in DNA Damage Response.
Upon a wide range of cellular stresses, p53 is activated and inhibits...
22nd October, 2009
Laboratory of Molecular Medicine, Human Genome Center, Division of Gene Cancer Res. 2009 Oct 20.
DOI Direct Link
Functional connection between deimination and deacetylation of histones.
Histone methylation plays key roles in regulating chromatin structure and...
16th September, 2009
Free University of Brussels, Faculty of Medicine, Laboratory of Cancer Mol Cell Biol. 2009 Sep;29(18):4982-93. Epub 2009 Jul 6.
DOI Direct Link
Genetics of rheumatoid arthritis: underlying evidence of ethnic differences.
A new age has begun in the genetics of rheumatoid arthritis (RA), as...
22nd July, 2009
University of Tokyo Hospital, Laboratory for Autoimmune Diseases, Center J Autoimmun. 2009 May-Jun;32(3-4):158-62. Epub 2009 Mar 26.
DOI Direct Link
Peptidylarginine deiminase 4 and citrullination in health and disease.
Deimination is catalyzed by a family of calcium binding enzymes, called...
23rd June, 2009
Clinical Immunology Unit, Department of Internal Medicine, University of Autoimmun Rev. 2009 Jun 18.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7595159 Prediction of Parkinson's disease using gene expression levels of peripheral blood samples
6962988 Egg specific surface proteins

PADI4 results (if any) from reagent suppliers

Google CSE Logo
PADI4 / PAD4 antibody (ab38772) | Abcam
Rabbit polyclonal to PADI4 / PAD4. In vivo expression of PADI4 correlates with the appearance of citrulline in histones. It has been demonstrated that PADI4
...
http://www.abcam.com/PADI4-PAD4-antibody-ab38772.html...

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PADI4 (K-18) Antibody sc-47287
goat polyclonal IgG, 200µg/ml; epitope mapping within an internal region of PADI4 of human origin; recommended for detection of PADI4 of human and, ...
http://www.scbt.com/datasheet-47287-padi4-k-18-antibody.html...

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P4749 Anti-PADI4 (N-terminal) antibody produced in rabbit IgG ...
P4749 Anti-PADI4 (N-terminal) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=P474...

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PADI4 (C-3) Antibody sc-166645
Western blot analysis of PADI4 expression in non-transfected: sc-117752 (A) and human PADI4 transfected: sc-114204 (B) 293T whole cell lysates. Download ...
http://www.scbt.com/datasheet-166645-padi4-c-3-antibody.html...

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PADI4 / PAD4 antibodies: Signal Transduction > Metabolism > Amino ...
PADI4 / PAD4 antibodies. ... PADI4 / PAD4 antibody. WB, ELISA ... PADI4 / PAD4 antibody. IP, WB, ELISA. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=73484&pt=1&c=712&ei=&mu=ra...

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PADI4 siRNA (h) sc-61283
Click here for details. suitable control antibody: PADI4 (K-18): sc-47287; sqRT- PCR Primer also available: PADI4 (h)-PR: sc-61283-PR, 20 µl ...
http://www.scbt.com/datasheet-61283-padi4-sirna-h.html...

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Histone H3 (citrulline 2 + 8 + 17) antibody [CitH3] - ChIP Grade ...
In WB ab5103 only recognizes human or bovine histone H3 when PADI4 and calcium .... Lane 1: PADI4 + Calcium Lane 2: H3 + PADI4 Lane 3: H3 + PADI4 + Calcium ...
http://www.abcam.com/Histone-H3-citrulline-2-8-17-antibody-C...

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