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BACE1

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Symbol:	BACE1
Name(s):	beta-site APP-cleaving enzyme 1
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	ASP2, BACE, FLJ90568, HSPC104, KIAA1149
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18307033	Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18182766	Data suggest that BACE1 polymorphism in exon 5 influences risk for late-onset Alzheimer's disease in those carrying the ApoE epsilon4 allele.
18182766	Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
11234778	Observational study of gene-disease association. (HuGE Navigator)
11684351	Observational study of gene-disease association. (HuGE Navigator)
11714100	Observational study of gene-disease association. (HuGE Navigator)
12535780	Observational study of gene-disease association. (HuGE Navigator)
12928915	Observational study of gene-disease association. (HuGE Navigator)
14681914	Observational study of gene-disease association. (HuGE Navigator)
15784960	Observational study of gene-disease association. (HuGE Navigator)
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
BIND	ATPase, Na+/K+ transporting, beta 1 polypeptide	beta-site APP-cleaving enzyme 1 isoform A preproprotein	BACE1 interacts with ATP1B1 (Na/K-ATPase, beta-subunit). This interaction was modelled on a demonstrated interaction between mouse BACE1 and human Na/K-ATPase, beta-subunit.	-	Pubmed
BIND	protein disulfide isomerase-associated 3 precursor	beta-site APP-cleaving enzyme 1 isoform A preproprotein	BACE1 interacts with PDIA3 (ERp60). This interaction was modelled on a demonstrated interaction between mouse BACE1 and human PDIA3.	-	Pubmed
HPRD	matrix metalloproteinase 2 preproprotein	beta-site APP-cleaving enzyme 1 isoform A preproprotein	-	-	Pubmed
HPRD	matrix metalloproteinase 2 preproprotein	beta-site APP-cleaving enzyme 1 isoform A preproprotein	-	-	Pubmed
BIND	prosaposin isoform a preproprotein	beta-site APP-cleaving enzyme 1 isoform A preproprotein	BACE1 interacts with PSAP (prosaposin). This interaction was modelled on a demonstrated interaction between mouse BACE1 and human prosaposin.	-	Pubmed
BIND	KH-type splicing regulatory protein	beta-site APP-cleaving enzyme 1 isoform A preproprotein	BACE1 interacts with KHSRP. This interaction was modelled on a demonstrated interaction between mouse BACE1 and human KHSRP.	-	Pubmed
BIND	RAN binding protein 9	beta-site APP-cleaving enzyme 1 isoform A preproprotein	BACE1 interacts with RANBP9 (RANBPM). This interaction was modelled on a demonstrated interaction between mouse BACE1 and human RANBPM.	-	Pubmed
HPRD	ADP-ribosylation factor binding protein 2	beta-site APP-cleaving enzyme 1 isoform A preproprotein	-	-	Pubmed
HPRD	nicastrin precursor	beta-site APP-cleaving enzyme 1 isoform A preproprotein	-	-	Pubmed
HPRD	nicastrin precursor	beta-site APP-cleaving enzyme 1 isoform A preproprotein	-	-	Pubmed

Recent Publications on BACE1:
Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. Oxidative stress is associated with beta-amyloid peptide (Abeta)...	4th November, 2009	Department of Demyelinating Disease and Aging, National Institute of	J Neurosci Res. 2009 Nov 2. DOI Direct Link
The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. The beta-amyloid (Abeta) peptide is the major constituent of amyloid...	31st October, 2009	Department of Cell and Molecular Biology, Northwestern University,	J Neurosci. 2009 Oct 14;29(41):12787-94. DOI Direct Link
Inhibitory effect of piperlonguminine/ dihydropiperlonguminine on the production of amyloid beta and APP in SK-N-SH cells. The study was undertaken to explore whether...	23rd October, 2009	Department of Cerebrovascular Disease, Qilu Hospital, Shandong University,	Chin J Physiol. 2009 Jun 30;52(3):160-8.
Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats. Previous studies have demonstrated that ischemic stroke increases...	22nd October, 2009	Department of Neurobiology, Institute of Biomedical Sciences, State Key	J Cereb Blood Flow Metab. 2009 Oct 21. DOI Direct Link
Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2. BACE2 is homologous to BACE1, a beta-secretase that is involved in the...	21st October, 2009	Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona	Genes Brain Behav. 2009 Sep 22. DOI Direct Link
→View more research publications.

Press Releases on BACE1:
Markers in Blood and Spinal Fluid, and a New Imaging Agent, Show Promise for Early Detection of Alzheimer's	29th July, 2008	Alzheimer's Association	CHICAGO, July 29 /PRNewswire-USNewswire/ -- With the continued aging of the population and the growing epidemic of Alzheimer's, early detection of the disease is crucial for risk
New molecular target identified for the prevention of Alzheimer's disease	1st January, 1970	Dailyupdates	New molecular target identified for the prevention of

BioNews Results for BACE1 :
AnaSpec, Inc. Introduces Secretase Enzyme & Assay	BioSpace: Oct 16 2009 6:49PM Matching: bace1

Patents:
US Patent No.	Title
7312188	Peptide derivatives having .beta.-secretase inhibitory activity
7408071	N-aryl pyrrolidine derivatives as beta-secretase inhibitors
7417047	Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for .beta.-secretase modulation
7423158	Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of .beta.-secretase
7429459	Methods for identifying a compound that inhibits the procession of amyloid-beta protein production in a mammalian cell expressing APP and overexpressing a G-protein coupled receptor in the cell
→View more patents.

BACE1 results (if any) from reagent suppliers

BACE1 antibody (ab23796) \| Abcam ab23796 recognises BACE1. Cross reactivity with BACE2 is almost negligible. ... See below for BACE1 antibody images, references, products related to ab23796 ... http://www.abcam.com/bace1-antibody-ab23796.html...
Anti-BACE1 Polyclonal Antibody Polyclonal Antibody against BACE1 for use in ELISA, Immunoprecipitation, Western Blot. http://www.bioreagents.com/products/productDetails/productDe...
BACE1 antibody (ab2077) \| Abcam See below for BACE1 antibody images, references, products related to ab2077 and other tools. ... Contact Abcam with a Technical Enquiry about BACE1 antibody ... http://www.abcam.com/bace1-antibody-ab2077.html...
bacE antibody, BACE1 Antibody, Goat Polyclonal Antibody Buy quality goat bacE antibody (interacts with human), anti-bacE, BACE1 antibody , goat polyclonal antibody, BACE1 Antibody, Goat Polyclonal Antibody (ihc-f ... http://www.genwaybio.com/product_info.php?products_id=76559...
BACE1 antibody (ab11028) \| Abcam Goat polyclonal to BACE1. BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the ... http://www.abcam.com/bace1-antibody-ab11028.html...
CATALOG NO.: SA-465 LOT NO.: temp PRODUCT: Anti-BACE1, rabbit ... BACE1 is expressed as a pre-pro-aspartyl protease, sometimes glycosylated, ... SPECIFICITY: Recognizes human, mouse, and rat zymogen and mature BACE1 (50-72 ... http://www.biomol.com/SiteData/docs/productdata/sa465.pdf...
BACE1 antibody - Catalytic domain (ab38891) \| Abcam Rabbit polyclonal to BACE1 - Catalytic domain. BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). http://www.abcam.com/bace1-antibody-catalytic-domain-ab38891...

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BACE1

Gene Information from Publications

Interacting gene products

Recent Publications on BACE1:

Press Releases on BACE1:

BioNews Results for BACE1

Patents:

BACE1 results (if any) from reagent suppliers