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GABARAPL1


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Gene DB Home
Symbol:GABARAPL1
Name(s):GABA(A) receptor-associated protein like 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:APG8L, ATG8, ATG8L, GEC1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16431922 GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor
14625090 Gec1/GABARAPL1 was more expressed than GABARAP in the central nervous system (CNS), while GABARAP was more expressed in endocrine glands.

Recent Publications on GABARAPL1:

Pubmed Logo
Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin.
Autophagy is essential for maintaining both survival and health of cells....
18th September, 2009
Translational Biology, The Hamner Institutes for Health Sciences, Durham, J Biol Chem. 2009 Nov 6;284(45):31484-92. Epub 2009 Sep 16.
DOI Direct Link
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.
Autophagy is an important catabolic process with roles in cell survival...
18th September, 2009
Cell Biology Laboratories, Department of Biochemistry, School of Medical J Cell Sci. 2009 Jul 15;122(Pt 14):2554-66. Epub 2009 Jun 23.
DOI Direct Link
FoxO transcription factors promote autophagy in cardiomyocytes.
In the heart, autophagy is required for normal cardiac function and also...
22nd August, 2009
Division of Molecular Cardiovascular Biology, Cincinnati Children's J Biol Chem. 2009 Oct 9;284(41):28319-31. Epub 2009 Aug 19.
DOI Direct Link
GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect.
We demonstrated previously that the protein GEC1 (glandular epithelial...
13th March, 2009
Department of Pharmacology, Temple University School of Medicine, J Biol Chem. 2009 Jan 16;284(3):1673-85. Epub 2008 Nov 11.
DOI Direct Link
Specific regional distribution of gec1 mRNAs in adult rat central nervous system.
GEC1 protein shares high identity with GABARAP (GABA(A)...
30th August, 2008
Universite de Franche-Comte, IFR 133, U.F.R. Sciences et Techniques, Brain Res. 2008 May 19;1210:103-15. Epub 2008 Mar 7.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods

GABARAPL1 results (if any) from reagent suppliers

Google CSE Logo
GABARAPL1 siRNA (h) sc-105386
GABARAPL1 siRNA, shRNA and Lentiviral Particle Gene Silencers ... GABARAPL1 shRNA (h) Lentiviral Particles: sc-105386-V, Lentiviral Particles DataSheet /
...
http://www.scbt.com/datasheet-105386-gabarapl1-sirna-h.html...

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Anti-ATG7 Polyclonal Antibody
Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, ...
http://www.bioreagents.com/products/productDetails/productDe...

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All GABA Receptors | Abcam
GABARAPL1 antibody. WB. Images. Rabbit polyclonal. Reacts with: Ms. Predicted: Hu. ab86497 · GABARAPL1 antibody. WB. Images. Rabbit polyclonal. Reacts with:
...
http://www.abcam.com/index.html?c=463...

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Abcam antibodies and reagents product map
... Delta Opioid Receptor proteins and peptides (3) · Endomorphin 2 antibodies ( 2) · Endomorphin 2 proteins and peptides (1) · GABARAPL1 antibodies (3) ...
http://www.abcam.com/index.html?cl=248&pageconfig=productmap...

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