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ALK


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Symbol:ALK
Name(s):anaplastic lymphoma receptor tyrosine kinase
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD246, Ki-1, TFG/ALK
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18165268 besides MYCN and ALK, other genes proximal and distal to MYCN are highly expressed in neuroblastoma
16604305 Observational study of gene-disease association. (HuGE Navigator)
17922009 Oncogenic NPM1-ALK contains the ALK catalytic domain plus NPM1 oligomerization motif and mediates malignant cell transformation by epigenetic silencing of signal transducer and activator of transcription STAT5A in T-cell anaplastic large cell lymphomas.
18166835 ALK is part of a fusion protein linked to histological characteristics in a subset of lung neoplasms.
18097461 Translocations or deregulated expression of ALK contribute to oncogenesis and genetic or pharmacological tools, aimed at neutralizing its activity in anaplastic lymphoma [REVIEW]
17904822 Pleiotrophin failed to activate anaplastic lymphoma kinase (ALK) in neuroblastoma/glioblastoma cells expressing this receptor. ALK is still an orphan receptor in vertebrates.
17690253 JunB is a critical target of mTOR and is translationally regulated in NPM-ALK-positive lymphomas.
17537995 identify splicing factor as a novel nucleophosmin 1/anaplastic lymphoma kinase-binding protein and substrate
17681947 phosphorylation of ALK in PTN-stimulated cells is mediated through the PTN/RPTPbeta/zeta signaling pathway
15226403 ALK receptor tyrosine kinase has roles promoting cell growth and neurite outgrowth

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDALKJanus kinase 3--Pubmed
HPRDanaplastic lymphoma kinase Ki-1Janus kinase 3--Pubmed
HPRDanaplastic lymphoma kinase Ki-1nucleophosmin 1 isoform 1--Pubmed
HPRDanaplastic lymphoma kinase Ki-1phospholipase C, gamma 1--Pubmed
HPRDanaplastic lymphoma kinase Ki-1phospholipase C gamma 1 isoform a--Pubmed
HPRDanaplastic lymphoma kinase Ki-1pleiotrophin--Pubmed
HPRDanaplastic lymphoma kinase Ki-1pleiotrophin--Pubmed
HPRDanaplastic lymphoma kinase Ki-1RAS p21 protein activator 1 isoform 1--Pubmed
HPRDanaplastic lymphoma kinase Ki-1RAS p21 protein activator 1 isoform 1--Pubmed
HPRDanaplastic lymphoma kinase Ki-1heat shock 90kDa protein 1, alpha--Pubmed

Recent Publications on ALK:

Pubmed Logo
MPN- and Real-Time-Based PCR Methods for the Quantification of Alkane Monooxygenase Homologous Genes (alkB) in Environmental Samples.
Hydrocarbons are major contaminants of soil ecosystems as a result of...
3rd November, 2009
Department for Terrestrial Ecogenetics, Helmholtz Zentrum Munchen, Methods Mol Biol. 2010;599:59-68.
DOI Direct Link
Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin and lipid transfer protein pan-allergens.
BACKGROUND: Allergy diagnosis needs to be improved in patients suffering...
31st October, 2009
Departamento de I+D, ALK-Abello, Madrid, Spain. Clin Exp Allergy. 2009 Nov;39(11):1764-73.
Analysis of human T-cell lymphotropic virus in CD25+ anaplastic large cell lymphoma in children.
Anaplastic large cell lymphoma (ALCL) is recognized as 2 distinct...
30th October, 2009
Consultoria em Patologia, Rua Major Leonidas Cardoso 739, Botucatu, SP, Am J Clin Pathol. 2009 Jul;132(1):28-33.
DOI Direct Link
Infant Anaplastic Large Cell Lymphoma with Hemophagocytic Syndrome.
Abstract Anaplastic large cell lymphoma (ALCL), ALK-positive, is uncommon...
30th October, 2009
1 PathWest, Princess Margaret Hospital. Pediatr Dev Pathol. 2009 Oct 19.
DOI Direct Link
Selective allergy to lobster in a case of primary sensitization to house dust mites.
Allergy to only 1 kind of seafood is uncommon. We report a case of...
30th October, 2009
Department of Allergology, Hospital General Yague, Burgos, Spain. J Investig Allergol Clin Immunol. 2009;19(5):409-13.

View more research publications.

Press Releases on ALK:

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Japanese Cancer Association and Debiopharm Honour Japanese Research 29th October, 2008 Debiopharm Group

LAUSANNE, Switzerland, October 29 /PRNewswire/ -- Debiopharm Group (Debiopharm), a global biopharmaceutical development specialist that focuses on serious medical conditions and particularly

Persistent Vaccination Effect of GRAZAX(R) After Completion of Treatment 22nd October, 2008

COPENHAGEN, October 22 /PRNewswire/ -- Breakthrough: Results from the fourth year in a long-term clinical study prove the disease modifying effect of GRAZAX(R). For the first time ever, it is

Positive SPA Reply From the FDA for TopoTarget's Pivotal Trial With Belinostat in PTCL 5th September, 2008

COPENHAGEN, Denmark, September 5 /PRNewswire/ -- TopoTarget A/S (OMX: TOPO) announced that a positive reply from the FDA was received on a Special Protocol Assessment (SPA) for a phase III trial

Scripps Translational Science Institute Contributes to Discovery of Predisposition Gene for Childhood Cancer 25th August, 2008 Scripps Translational Science Institute

SAN DIEGO, Aug. 25 /PRNewswire/ -- Researchers at Scripps Translational Science Institute (STSI) have contributed to a major genetic breakthrough -- the discovery of a gene responsible for the

Gene That Causes Childhood Cancer Neuroblastoma Is Found 25th August, 2008 The Children's Hospital of Philadelphia

--May Lead to New Prevention and Treatment Strategies--

PHILADELPHIA, Aug. 25 /PRNewswire-USNewswire/ -- Scientists have discovered gene mutations that are the main

BioNews Results for ALK

: RSS Logo
BioPortfolio Logo
Alkermes Announces Positive Results From Two Clinical Trials of ALKS 33
PharmiWeb:  Oct 14 2009 2:46AM Matching: alk
Alkermes (ALKS) Announces Positive Results From Two Clinical Trials of ALKS 33
BioSpace:  Oct 14 2009 12:44AM Matching: alk
Good News for Alkermes' Pipeline
Cafepharma:  Oct 14 2009 3:38PM Matching: alk
Alkermes Anti-Addiction Drug, Key to Company Pipeline, Passes Early Test
Xconomy:  Oct 14 2009 9:19AM Matching: alk
SADIF Analytics releases new summary due diligence report for Alkermes, Inc
PR inside:  Oct 14 2009 1:45PM Matching: alk
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
An Investigational Drug, PF-02341066, Is Being Studied In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene

Patents:

Patents logo
US Patent No.Title
7582750 Method for conversion of terminal alkenes to aldehydes using ruthenium (IV) porphyrin catalysts
7589116 Biaryl substituted pyrazoles as sodium channel blockers
7589117 Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them
7589120 N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application
7589123 Chemical compounds

View more patents.

ALK results (if any) from reagent suppliers

Google CSE Logo
ALK antibody (ab4061) | Abcam
Rabbit polyclonal to ALK. Anaplastic lymphoma kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. ALK and LTK (leukocyte
...
http://www.abcam.com/ALK-antibody-ab4061.html...

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ALK Antibody / ALK Antibodies
ALK Antibody / ALK Antibodies. ... ALK specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-alk.html...

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ALK Antibody (C-term)
ALK Antibody (C-term). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the ...
http://www.abgent.com/products/catalog_no/AP7600b_ALK_Antibo...

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Phospho-ALK (Tyr1586) Antibody #3343
Western blot analysis of extracts from various cells expressing different activated tyrosine kinases, using Phospho-ALK (Tyr1586) Antibody (upper) or ...
http://www.cellsignal.com/products/3343.html...

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ALK-1 Antibody / ALK-1 Antibodies
ALK-1 Antibody / ALK-1 Antibodies. ... ALK-1 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-alk-1.html...

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Phospho-ALK (Tyr1278) Antibody #3710
Phospho-ALK (Tyr1278) Antibody detects ALK only when phosphorylated at Tyr1278, which is equivalent to Tyr876 of NPM-ALK. This antibody also reacts with ...
http://www.cellsignal.com/products/3710.html...

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ALK (T-18) Antibody sc-6345
goat polyclonal IgG, 200 µg/ml; epitope mapping at the N-terminus of ALK of ... See how others have used ALK (T-18): sc-6345 antibody and or ALK (T-18) ...
http://www.scbt.com/datasheet-6345-alk-t-18-antibody.html...

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