Sunday November 22 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

ALK


Suggest Content
Advertise Here
Gene DB Home
Symbol:ALK
Name(s):anaplastic lymphoma receptor tyrosine kinase
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD246, Ki-1, TFG/ALK
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18165268 besides MYCN and ALK, other genes proximal and distal to MYCN are highly expressed in neuroblastoma
16604305 Observational study of gene-disease association. (HuGE Navigator)
17922009 Oncogenic NPM1-ALK contains the ALK catalytic domain plus NPM1 oligomerization motif and mediates malignant cell transformation by epigenetic silencing of signal transducer and activator of transcription STAT5A in T-cell anaplastic large cell lymphomas.
18166835 ALK is part of a fusion protein linked to histological characteristics in a subset of lung neoplasms.
18097461 Translocations or deregulated expression of ALK contribute to oncogenesis and genetic or pharmacological tools, aimed at neutralizing its activity in anaplastic lymphoma [REVIEW]
17904822 Pleiotrophin failed to activate anaplastic lymphoma kinase (ALK) in neuroblastoma/glioblastoma cells expressing this receptor. ALK is still an orphan receptor in vertebrates.
17690253 JunB is a critical target of mTOR and is translationally regulated in NPM-ALK-positive lymphomas.
17537995 identify splicing factor as a novel nucleophosmin 1/anaplastic lymphoma kinase-binding protein and substrate
17681947 phosphorylation of ALK in PTN-stimulated cells is mediated through the PTN/RPTPbeta/zeta signaling pathway
15226403 ALK receptor tyrosine kinase has roles promoting cell growth and neurite outgrowth

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDALKJanus kinase 3--Pubmed
HPRDanaplastic lymphoma kinase Ki-1Janus kinase 3--Pubmed
HPRDanaplastic lymphoma kinase Ki-1nucleophosmin 1 isoform 1--Pubmed
HPRDanaplastic lymphoma kinase Ki-1phospholipase C, gamma 1--Pubmed
HPRDanaplastic lymphoma kinase Ki-1phospholipase C gamma 1 isoform a--Pubmed
HPRDanaplastic lymphoma kinase Ki-1pleiotrophin--Pubmed
HPRDanaplastic lymphoma kinase Ki-1pleiotrophin--Pubmed
HPRDanaplastic lymphoma kinase Ki-1RAS p21 protein activator 1 isoform 1--Pubmed
HPRDanaplastic lymphoma kinase Ki-1RAS p21 protein activator 1 isoform 1--Pubmed
HPRDanaplastic lymphoma kinase Ki-1heat shock 90kDa protein 1, alpha--Pubmed

Recent Publications on ALK:

Pubmed Logo
MPN- and Real-Time-Based PCR Methods for the Quantification of Alkane Monooxygenase Homologous Genes (alkB) in Environmental Samples.
Hydrocarbons are major contaminants of soil ecosystems as a result of...
3rd November, 2009
Department for Terrestrial Ecogenetics, Helmholtz Zentrum Munchen, Methods Mol Biol. 2010;599:59-68.
DOI Direct Link
Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin and lipid transfer protein pan-allergens.
BACKGROUND: Allergy diagnosis needs to be improved in patients suffering...
31st October, 2009
Departamento de I+D, ALK-Abello, Madrid, Spain. Clin Exp Allergy. 2009 Nov;39(11):1764-73.
Analysis of human T-cell lymphotropic virus in CD25+ anaplastic large cell lymphoma in children.
Anaplastic large cell lymphoma (ALCL) is recognized as 2 distinct...
30th October, 2009
Consultoria em Patologia, Rua Major Leonidas Cardoso 739, Botucatu, SP, Am J Clin Pathol. 2009 Jul;132(1):28-33.
DOI Direct Link
Infant Anaplastic Large Cell Lymphoma with Hemophagocytic Syndrome.
Abstract Anaplastic large cell lymphoma (ALCL), ALK-positive, is uncommon...
30th October, 2009
1 PathWest, Princess Margaret Hospital. Pediatr Dev Pathol. 2009 Oct 19.
DOI Direct Link
Selective allergy to lobster in a case of primary sensitization to house dust mites.
Allergy to only 1 kind of seafood is uncommon. We report a case of...
30th October, 2009
Department of Allergology, Hospital General Yague, Burgos, Spain. J Investig Allergol Clin Immunol. 2009;19(5):409-13.

View more research publications.

Press Releases on ALK:

BioPortfolio Logo
ThromboGenics and BioInvent Complete Phase I Patient Trial of Anti-PlGF Cancer Therapeutic TB-403 in Patients With Advanced Solid Tumours 16th November, 2009

LEUVEN, Belgium and LUND, Sweden, November 16 /PRNewswire/ -- ThromboGenics NV (Euronext Brussels: THR) and BioInvent International AB (OMXS: BINV) today announced positive results from a Phase I

Dishler Laser Institute Announces Dr. Jon Dishler Selected as a Leading Laser Eye Surgeon of the United States, as Seen in Forbes Magazine 16th November, 2009 Dishler Laser Institute

GREENWOOD VILLAGE, Colo., Nov. 16 /PRNewswire/ -- Dishler Laser Institute announced today that Dr. Jon Dishler has been selected by

ALK Announces Landmark Asthma Prevention Trial 16th November, 2009

COPENHAGEN, Denmark, November 16 /PRNewswire/ -- GAP will be the largest ever trial to investigate the asthma preventive effect of specific immunotherapy in children (5-12 years old) with allergic

Japanese Cancer Association and Debiopharm Honour Japanese Research 29th October, 2008 Debiopharm Group

LAUSANNE, Switzerland, October 29 /PRNewswire/ -- Debiopharm Group (Debiopharm), a global biopharmaceutical development specialist that focuses on serious medical conditions and particularly

Persistent Vaccination Effect of GRAZAX(R) After Completion of Treatment 22nd October, 2008

COPENHAGEN, October 22 /PRNewswire/ -- Breakthrough: Results from the fourth year in a long-term clinical study prove the disease modifying effect of GRAZAX(R). For the first time ever, it is

BioNews Results for ALK

: RSS Logo
BioPortfolio Logo
Alkermes to Webcast Corporate Presentation at the Lazard Capital Markets Healthcare Conference
TradingMarkets:  Nov 13 2009 5:37AM Matching: alk
BioInvent Signs Licensing Agreement with Daiichi Sankyo for the Discovery and Development of Therapeutic Antibodies
NewsBlaze:  Nov 13 2009 10:55AM Matching: alk
Alkermes (ALKS)' Corporate Presentation to be Webcast at the Lazard Capital Markets Healthcare Conference
BioSpace:  Nov 11 2009 7:42PM Matching: alk
xtremepicks.com: Xtremepicks.com Alerts for Nov 10, 2009 -- Yahoo Inc (YHOO) & Microsoft Inc (MSFT), Monsanto Co. (MON), Alaska Airlines (ALK)
Individual.com:  Nov 11 2009 10:23AM Matching: alk
xtremepicks.com: Xtremepicks.com Alerts for Nov 10, 2009 -- Yahoo Inc (YHOO) & Microsoft Inc (MSFT), Monsanto
TradingMarkets:  Nov 11 2009 10:09AM Matching: alk
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
An Investigational Drug, PF-02341066, Is Being Studied In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene

Patents:

Patents logo
US Patent No.Title
7595311 Azepinoindole derivatives as pharmaceutical agents
7601180 Use for the dyeing with lightening effect of keratin substances of a composition comprising a fluorescent cyanine dye
7601355 Compositions and methods for altering immune function
7601678 Washing and cleaning agents comprising fine microparticles with cleaning agent components
7601679 Process for producing a hollow body with a compartment, containing a portion of a washing, cleaning or rinsing agent

View more patents.

ALK results (if any) from reagent suppliers

Google CSE Logo
ALK antibody (ab4061) | Abcam
Rabbit polyclonal to ALK. Anaplastic lymphoma kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. ALK and LTK (leukocyte
...
http://www.abcam.com/ALK-antibody-ab4061.html...

Thumbshot
ALK Antibody / ALK Antibodies
ALK Antibody / ALK Antibodies. ... ALK specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-alk.html...

Thumbshot
ALK Antibody (C-term)
ALK Antibody (C-term). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the ...
http://www.abgent.com/products/catalog_no/AP7600b...

Thumbshot
Phospho-ALK (Tyr1586) Antibody #3343
Western blot analysis of extracts from various cells expressing different activated tyrosine kinases, using Phospho-ALK (Tyr1586) Antibody (upper) or ...
http://www.cellsignal.com/products/3343.html...

Thumbshot
ALK-1 Antibody / ALK-1 Antibodies
ALK-1 Antibody / ALK-1 Antibodies. ... ALK-1 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-alk-1.html...

Thumbshot
Phospho-ALK (Tyr1278) Antibody #3710
Phospho-ALK (Tyr1278) Antibody detects ALK only when phosphorylated at Tyr1278, which is equivalent to Tyr876 of NPM-ALK. This antibody also reacts with ...
http://www.cellsignal.com/products/3710.html...

Thumbshot
ALK (T-18) Antibody sc-6345
goat polyclonal IgG, 200 µg/ml; epitope mapping at the N-terminus of ALK of ... See how others have used ALK (T-18): sc-6345 antibody and or ALK (T-18) ...
http://www.scbt.com/datasheet-6345-alk-t-18-antibody.html...

Thumbshot

Search Bioportfolio and other Life Science Sites for ALK, or search for ALK on BioPortfolio's antibody search engine.
This page has been viewed 925 times
Recent Search Terms used to find this page:
anaplastic lymphoma kinase ALK pipeline | ALK anaplastic antibody N-terminus | antibodies ALK | ALK kinase plasmid | alk kinase | alk neuroblastoma | ALK kinase | ALK kinase | alk anaplastic lymphoma receptor tyrosine kinase | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.