Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18165268 |
besides MYCN and ALK, other genes proximal and distal to MYCN are highly expressed in neuroblastoma |
| 16604305 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17922009 |
Oncogenic NPM1-ALK contains the ALK catalytic domain plus NPM1 oligomerization motif and mediates malignant cell transformation by epigenetic silencing of signal transducer and activator of transcription STAT5A in T-cell anaplastic large cell lymphomas. |
| 18166835 |
ALK is part of a fusion protein linked to histological characteristics in a subset of lung neoplasms. |
| 18097461 |
Translocations or deregulated expression of ALK contribute to oncogenesis and genetic or pharmacological tools, aimed at neutralizing its activity in anaplastic lymphoma [REVIEW] |
| 17904822 |
Pleiotrophin failed to activate anaplastic lymphoma kinase (ALK) in neuroblastoma/glioblastoma cells expressing this receptor. ALK is still an orphan receptor in vertebrates. |
| 17690253 |
JunB is a critical target of mTOR and is translationally regulated in NPM-ALK-positive lymphomas. |
| 17537995 |
identify splicing factor as a novel nucleophosmin 1/anaplastic lymphoma kinase-binding protein and substrate |
| 17681947 |
phosphorylation of ALK in PTN-stimulated cells is mediated through the PTN/RPTPbeta/zeta signaling pathway |
| 15226403 |
ALK receptor tyrosine kinase has roles promoting cell growth and neurite outgrowth |
| 17274988 |
A functional role for Shc and likely FRS2 in ALK-dependant MAP-kinase activation and neuronal differentiation of PC12 cells. |
| 11877285 |
ALK as a novel lymphoma-associated tumor antigen: identification of 2 HLA-A2.1-restricted CD8+ T-cell epitopes. |
| 12122009 |
midkine binds to ALK and has a role in signal transduction for cell growth and survival |
| 15886198 |
analysis of differentiation of PC12 cells and human embryonic kidney 293 cells transfected with ALK shows absence of agonist activity of pleiotrophin |
| 17077326 |
molecular signature of ALK- anaplastic large-cell lymphoma included overexpression of CCR7, CNTFR, IL22, and IL21 genes |
| 16651537 |
can be adapted for the identification of known and unknown translocation partners of chimeric ALK fusion proteins involved in oncogenesis |
| 15933425 |
CONCLUSIONS: ALK-ALCL arising in the skin represents a single disease with a broad spectrum of morphology; clinicians and pathologists should be aware of this neutrophil-rich (NR) variant with aggressive clinical presentation. |
| 15583856 |
ALK has roles in oncogenesis of haematopoietic and non-haematopoietic tumors [review] |
| 16153455 |
We conclude that Jak3 activation is predominantly restricted to ALK-positive ALCL tumors. |
| 16161041 |
Genomic PCR and subsequent sequencing showed that the breakpoints were located in intron 23 of SEC31-like 1 protein-transport protein and intron 20 of ALK |
| 15161657 |
STAT3 directly contributes to the high level of TIMP1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. |
| 15713979 |
Although 9 of 36 patients with cutaneous CD30(+) lymphoproliferative diseases had progression of their disease, neither mutations of the p53 gene nor ALK immunoreactivity were found in any of these biopsies. |
| 15928040 |
ALK-mediated alphaDGK activation is dependent on p60src tyrosine kinase, with which alphaDGK forms a complex; alphaDGK activation is involved in the control of ALK-mediated mitogenic properties. |
| 11809760 |
Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth |
| 12763927 |
novel fusion created by the ALK gene on chromosome 2p23 and NPM on 5q35 or other variant translocation partners in a rare variant of diffuse large B-cell lymphoma |
| 14962911 |
FOXO3a is a barrier to hematopoietic transformation that is overcome by phosphorylation and cytoplasmic relocalization induced by the expression of NPM-ALK |
| 14563642 |
Src-kinases, particularly pp60(c-src), associate with and are activated by NPM-ALK expression in various cells, and in cell lines established from patients with large cell lymphoma |
| 12213716 |
co-expression of c-Myc and ALK was seen in tumor cells of ALK-positive anaplastic large cell lymphomas; C-Myc may be a downstream target of ALK signaling |
| 17071493 |
CD26 and cell surface adenosine deaminase are selectively expressed on ALK-positive, but not on ALK-negative, anaplastic large cell lymphoma and Hodgkin's lymphoma |
| 12185581 |
ALK-ShcC signal activation, possibly caused by co-amplification with the N-myc gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK kinase. |
| 16623783 |
Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract may show ALK immunopositivity but do not show consistent ALK rearrangement by fluorescent in situ hybridization. |
| 16766651 |
NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells secrete IL-10 and TGF-beta and express FoxP3, indicating their T regulatory (Treg) cell phenotype. |
| 17490616 |
This study thus supports the possibility that activated ALK may be important in human breast cancers and potentially activated either through the PTN/RPTPbeta/zeta signaling pathway. |
| 12036886 |
ALK-positive anaplastic large cell lymphoma had significantly higher levels of caspase 3, while high expression of the antiapoptotic proteins Bcl-2 and PI9 was almost completely restricted to ALK-negative cases. |
| 12800156 |
In a case of anaplastic large cell lymphoma, ALK is fused to a portion of non-muscle myosin heavy chain gene, MYH9, localized 6 bp downstream of MSN-ALK in the same exonic sequence, resulting in an in-frame fusion of the two partner proteins. |
| 12112524 |
Novel fusion partners CARS and KIAA1618 (ALO17) have been detected with variant rearrangements of ALK in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases. |
| 16254137 |
Potent and selective ALK inhibitors may have therapeutic application for anaplastic lymphoma kinase. |
| 14656879 |
results show a pivotal role for Bcl-XL in ALK-mediated oncogenicity |
| 15004538 |
High dose therapy and stem cell transplantation does not produce long-term disease free survival in patients with recurrent chemotherapy-sensitive ALK-negative large cell lymphoma. |
| 16825495 |
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma. |
| 16878150 |
recruitment of insulin receptor substrate-1 to activated ALK and the activation of NF-kappaB are essential for the autocrine growth and survival signaling of midkine |
| 16880530 |
ALK has a proapoptotic activity in the absence of ligand, whereas it is antiapoptotic in the presence of its ligand and when the kinase is intrinsically activated. |
| 12115586 |
results do not support any involvement of ALK in the stimulation of tumorigenic cell growth or differentiation |
| 16709933 |
constitutive expression of C/EBPbeta in ALK-positive anaplastic large cell lymphoma and its relationship to NPM-ALK |
| 16835382 |
AUF1 was phosphorylated by ALK in vitro and was hyperphosphorylated in NPM-ALK-expressing cells. |
