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ALOX5


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Symbol:ALOX5
Name(s):arachidonate 5-lipoxygenase
Type:protein-coding
Organism:Homo sapiens
Synonyms:5-LO, 5-LOX, 5LPG, LOG5, MGC163204
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18204779 Observational study of gene-disease association. (HuGE Navigator)
18339529 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
11471199 Uncategorized study of gene-disease association and gene-environment interaction. (HuGE Navigator)
12107604 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
12911785 Observational study of gene-disease association. (HuGE Navigator)
14749922 Observational study of gene-disease association. (HuGE Navigator)
15308583 Observational study of gene-disease association. (HuGE Navigator)
16293801 Observational study of gene-disease association. (HuGE Navigator)
16361798 Observational study of gene-disease association. (HuGE Navigator)
16364163 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDArachidonate 5 lipoxygenasetransforming growth factor, beta receptor associated protein 1--Pubmed
HPRDarachidonate 5-lipoxygenaseTGF beta receptor associated protein 1--Pubmed
HPRDarachidonate 5-lipoxygenasearachidonate 5-lipoxygenase-activating protein--Pubmed
HPRDarachidonate 5-lipoxygenasearachidonate 5-lipoxygenase-activating protein--Pubmed
HPRDarachidonate 5-lipoxygenasegrowth factor receptor-bound protein 2 isoform 1--Pubmed
HPRDarachidonate 5-lipoxygenasegrowth factor receptor-bound protein 2 isoform 1--Pubmed
BINDarachidonate 5-lipoxygenasetransforming growth factor, beta receptor associated protein 15LO interacts with TRAP-1.-Pubmed
HPRDarachidonate 5-lipoxygenasecoactosin-like 1--Pubmed
HPRDarachidonate 5-lipoxygenasecoactosin-like 1--Pubmed
BINDarachidonate 5-lipoxygenasecoactosin-like 15LO interacts with CLP.-Pubmed

Recent Publications on ALOX5:

Pubmed Logo
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia.
Cancer stem cells (CSCs) are believed to be the initiating cells for many...
14th October, 2009
Division of Hematology/Oncology, Department of Medicine, University of Cell Cycle. 2009 Nov 19;8(21).
Association of genetic variants with myocardial infarction in individuals with or without hypertension or diabetes mellitus.
Hypertension and diabetes mellitus are important risk factors for...
30th September, 2009
Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Int J Mol Med. 2009 Nov;24(5):701-9.
Genetics and pharmacogenetics of the leukotriene pathway.
Leukotrienes are now established contributors to the inflammatory process...
29th September, 2009
Channing Laboratory, Brigham and Women's Hospital and Harvard Medical J Allergy Clin Immunol. 2009 Sep;124(3):422-7. Epub 2009 Aug 8.
DOI Direct Link
Inhibitors of the 5-lipoxygenase pathway in atherosclerosis.
The inflammatory environment within the atherosclerotic lesion stimulates...
17th September, 2009
Department of Cardiology and Center for Molecular Medicine, Karolinska Curr Pharm Des. 2009;15(27):3116-32.
Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity.
AIMS: Typically, only a proportion of the patients suffering from common...
17th September, 2009
Department of Human and Molecular Genetics, Virginia Commonwealth Pharmacogenomics. 2009 May;10(5):753-67.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Fish Oil to Prevent Asthma Exacerbations in Patients With ALOX5 Polymorphisms

Patents:

Patents logo
US Patent No.Title
7598052 Expression profile of thyroid cancer
6566065 Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
6673908 Tumor necrosis factor receptor 2
6716579 Gene specific arrays, preparation and use
6727063 Single nucleotide polymorphisms in genes

View more patents.

ALOX5 results (if any) from reagent suppliers

Google CSE Logo
5-LO (N-19) Antibody sc-8885
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ALOX5, 240, 10q11.21, NM_000698 ...
http://www.scbt.com/datasheet-8885-5-lo-n-19-antibody.html...

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Antibodies to Lipids in Cell Signaling
rat ... Alox5(25290), human, rat, IF (i), IHC (p), IP, WB, pricing. L2915, Anti- phospho-Lipid Phosphate Phosphatase 3 (LPP3) antibody produced in rabbit ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Abgent - Cell and Function Antibodies
AT1123a, ALOX15 monoclonal antibody (M04), ELISA,IHC-P,S-ELISA,WB-Ce,WB-Re, H. AP7856bNEW, ALOX5 Antibody (C-term), WB, E, H ...
http://www.abgent.com/products/category/cell_function...

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Phospho-5-Lipoxygenase (Ser663) Antibody #3749
5-Lipoxygenase (5-LO, ALOX5) is an important catalytic enzyme responsible for the biosynthesis of leukotriene LTA4 from arachidonic acid (1,2). ...
http://www.cellsignal.com/products/3749.html...

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Polyclonal Antibodies :: Page 13
ALOX15B Antibody, 49-993, n/a, WB, IHC, 15S-lipoxygenase. ALOX5 Antibody, 48-722 , M, R, P, HM, WB, IHC, ICC, Arachidonate 5-lipoxygenase ...
http://www.prosci-inc.com/shop/catalog1/Polyclonal-Antibodie...

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Abgent - Metabolism Antibodies - Metabolism
AP2736b, ALDOC Antibody (C-term), WB, IHC, E, H. AP7896bNEW, ALOX15 Antibody (C- term), WB, IHC, E, H. AP7856bNEW, ALOX5 Antibody (C-term), WB, E, H ...
http://www.abgent.com/products/category/cell_function/metabo...

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LO Antibody / LO Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. 5-LO (C-19) Antibody, sc-8886, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, h ...
http://www.scbt.com/ko/table-lo.html...

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