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ALOX15


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Gene DB Home
Symbol:ALOX15
Name(s):arachidonate 15-lipoxygenase
Type:protein-coding
Organism:Homo sapiens
Synonyms:15-LOX-1, 15-LOX2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17991885 expression of endogenous rabbit peroxisome proliferator-activating receptor and VEGFR2 were significantly increased in the growth factor-transduced muscles, but these inductions were efficiently prevented by 15-LO-1.
18239141 REVIEW: inhibitory effect of 15-LO-1 on VEGF- or PlGF-induced angiogenesis
16598376 Observational study of gene-disease association. (HuGE Navigator)
17439326 Observational study of gene-disease association. (HuGE Navigator)
17520163 Observational study of gene-disease association. (HuGE Navigator)
17652958 Observational study of gene-disease association. (HuGE Navigator)
17959182 Observational study of gene-disease association. (HuGE Navigator)
15838625 Observational study of gene-disease association. (HuGE Navigator)
18180398 Increased expression of 15-lipoxygenase-1 increases acetylcholine relaxation in arteries and hypotensive responses in rabbits because of increased hydroxy-epoxyeicosatrienoic acid and trihydroxyeicosatrienoic acid synthesis.
18090132 15-lipoxygenase-2 mRNA is strongly augmented during ovarian carcinogenesis and that the enzyme may constitute a suitable candidate as a tumor marker.

View more information from publications.

Recent Publications on ALOX15:

Pubmed Logo
Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton.
Loss of bone mass with advancing age in mice is because of decreased...
22nd October, 2009
Division of Endocrinology and Metabolism, Center for Osteoporosis and J Biol Chem. 2009 Oct 2;284(40):27438-48. Epub 2009 Aug 5.
DOI Direct Link
Structural basis for pH-dependent alterations of reaction specificity of vertebrate lipoxygenase isoforms.
Lipoxygenases have been classified according to their specificity of fatty...
24th September, 2009
Institute of Biochemistry, University Medicine Berlin - Charite, Germany. Biochim Biophys Acta. 2009 Aug;1791(8):827-35. Epub 2009 May 28.
DOI Direct Link
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).
Acute lung injury (ALI) is a prevalent disease associated with high...
16th September, 2009
Robert M. Berne Cardiovascular Research Center, Department of J Immunol. 2009 Oct 1;183(7):4715-22. Epub 2009 Sep 14.
DOI Direct Link
Lack of association of ALOX12 and ALOX15 polymorphisms with aspirin-exacerbated respiratory disease in Korean patients.
Acute lung injury (ALI) is a prevalent disease associated with high...
12th September, 2009
Ann Allergy Asthma Immunol. 2009 Jul;103(1):84-6.
No association of two functional polymorphisms in human ALOX15 with myocardial infarction.
The 12/15-lipoxygenase plays a janus-role in inflammation with...
26th August, 2009
Division of Clinical Chemistry and Biochemistry, University Children's Atherosclerosis. 2009 Jul;205(1):192-6. Epub 2008 Nov 27.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal Cancers

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7371207 Estrogen receptor .alpha. regulated gene expression, related assays and therapeutics
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
6727063 Single nucleotide polymorphisms in genes

View more patents.

ALOX15 results (if any) from reagent suppliers

Google CSE Logo
ALOX15 Antibody ALOX15
ALOX15 antibody was raised against a synthetic peptide of ALOX15.,
http://www.prosci-inc.com/shop/catalog1/ALOX15-Antibody-p-27...

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Abgent - Cell and Function Antibodies
AP7896bNEW, ALOX15 Antibody (C-term), WB, IHC, E, H. AT1123a, ALOX15 monoclonal antibody (M04), ELISA,IHC-P,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...

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Obesity Antibodies :: Page 1
ALBP (aP2) Antibody, XG-6174, H, E, WB, Adipocyte Lipd or Fatty Acid Binding Protein, or aP2. ALOX15 Antibody, 46-769, H, E, WB, ALOX15 ...
http://www.prosci-inc.com/shop/catalog1/Obesity-Antibodies-p...

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15-LO (H-235) Antibody sc-32940
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ALOX15, 246, 17p13.2, NM_001140 ...
http://www.scbt.com/datasheet-32940-15-lo-h-235-antibody.htm...

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Abgent - Metabolism Antibodies - Metabolism
AP2726b, ALDOA Antibody (C-term), WB, IHC, E, H. AP2736b, ALDOC Antibody (C-term ), WB, IHC, E, H. AP7896bNEW, ALOX15 Antibody (C-term), WB, IHC, E, H ...
http://www.abgent.com/products/category/cell_function/metabo...

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3C-3E
Monoclonal Anti-ALOX15 antibody produced in mouse clone 3D8, purified immunoglobulin, buffered aqueous solution, 3D8 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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LO Antibody / LO Antibodies
製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. 5-LO ( C-19) 抗体, sc-8886, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, h ...
http://www.scbt.com/ja/table-lo.html...

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