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ALOX15B


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Symbol:ALOX15B
Name(s):arachidonate 15-lipoxygenase, type B
Type:protein-coding
Organism:Homo sapiens
Synonyms:15-LOX-2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18156936 Loss of heterozygosity on 17p13 and down-regulation of ALOX15B can be used to discriminate adrenal cortex neoplasms from adrenocortical adenoma.
16682954 Crosstalk mechanisms exist between the 15-LOX-2 gene and peroxisome proliferator-activated receptor gamma (PPARgamma) to counterbalance expression and help explain the inverse relationship of these genes in normal prostate versus prostate cancer cells.
15799828 feedback mechanisms may contribute to the loss of 15-LOX-2 pathway components, which coincide with an increase in PPAR-gamma in many epithelial cancers
12659684 15-LOX-2 expression is lost in esophageal cancers and the induction of 15-LOX-2 can inhibit cancer cell proliferation
11839751 a negative cell cycle regulator in normal prostate epithelial cells, but not present in prostatic neoplasms
12704195 15-LOX2 and its splice variants suppress prostate tumor development
15247906 Sp1 and Sp3 proteins play a physiologically important role in positively and negatively regulating the 15-LOX2 gene expression, respectively.
15797645 angiotensin II upregulates LOX-1 and 12-LO and 15-LO expression in human vascular smooth muscle cells
16556493 Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer

Recent Publications on ALOX15B:

Pubmed Logo
Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.
Allosteric regulation of human lipoxygenase (hLO) activity has recently...
29th September, 2009
Chemistry and Biochemistry Department, University of California, Santa Biochemistry. 2009 Sep 15;48(36):8721-30.
DOI Direct Link
Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1.
The integrity of the retinal pigment epithelial (RPE) cell is essential...
7th August, 2009
Neuroscience Center of Excellence, Louisiana State University Health J Biol Chem. 2009 Jun 26;284(26):17877-82. Epub 2009 Apr 29.
DOI Direct Link
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
The high incidence of lung cancer in Xuanwei County, China has been...
15th May, 2009
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Environ Mol Mutagen. 2009 May;50(4):285-90.
DOI Direct Link
15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration.
BACKGROUND: We determined previously that hypoxia results in increased...
8th August, 2008
Sahlgrenska Centre for Cardiovascular and Metabolic Research, Wallenberg Atherosclerosis. 2008 Jul;199(1):34-40. Epub 2007 Dec 11.
DOI Direct Link
15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary.
Ovarian cancer is a major cause of lethality from gynecological...
26th February, 2008
Institute of Biochemistry, University Medicine Berlin-Charite, Berlin, Eur J Cancer Prev. 2007 Dec;16(6):568-75.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6706867 DNA array sequence selection
6673908 Tumor necrosis factor receptor 2
6479546 Allosteric inhibitors of lipoxygenase

ALOX15B results (if any) from reagent suppliers

Google CSE Logo
Polyclonal Antibodies :: Page 13
ALOX15B Antibody, 49-993, n/a, WB, IHC, 15S-lipoxygenase. ALOX5 Antibody, 48-722 , M, R, P, HM, WB, IHC, ICC, Arachidonate 5-lipoxygenase ...
http://www.prosci-inc.com/shop/catalog1/Polyclonal-Antibodie...

Thumbshot
15-LO2 siRNA (h) sc-45626
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, ALOX15B, 247, 17p13.1, NM_001039130,
...
http://www.scbt.com/ja/datasheet-45626-15-lo2-sirna-h.html...

Thumbshot
15-LO2 (H-55) Antibody sc-67142
... Numero de acesso de proteina, OMIM&trande; Numero. Humano, ALOX15B, 247, 17p13.1, NM_001039130, NM_001039131, NM_001141 · O15296 ...
http://www.scbt.com/pt/datasheet-67142-15-lo2-h-55-antibody....

Thumbshot
15-LO2 (H-55) Antibody sc-67142
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ALOX15B, 247, 17p13.1, NM_001039130,
...
http://www.scbt.com/ko/datasheet-67142-15-lo2-h-55-antibody....

Thumbshot
15-LO2 (H-55) Antibody sc-67142
... mRNA (Isoform) Accession #, Protein Accession #, OMIM™ Nummer. Human, ALOX15B, 247, 17p13.1, NM_001039130, NM_001039131, NM_001141 · O15296 ...
http://www.scbt.com/de/datasheet-67142-15-lo2-h-55-antibody....

Thumbshot

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15-LOX2 | Arachidonate 15-lipoxygenase types | ATM 150209 | Loss of Heterozygosity of 17p13 With Possible Involvement of ACADVL and ALOX15B in the Pathogenesis of Adrenocortical Tumors. | OBJECTIVE OF 15 LOX-2 IN CANCER | .


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