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FRAP1
| Symbol: | FRAP1 | | Name(s): | FK506 binding protein 12-rapamycin associated protein 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FLJ44809, FRAP, FRAP2, MTOR, RAFT1, RAPT1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17914450 |
These data implicate activation of mTOR in the pathogenesis of melanoma, and suggest that Rheb and mTOR may be targets for melanoma therapy. |
| 18048359 |
a key regulatory role of the Akt/mTOR pathway in the generation of the effects of As(2)O(3) |
| 17372934 |
Changes in tissue pressure during inflammation may regulate macrophage phagocytosis by activation of PI-3K, which activates Akt2, mTOR, and p70S6K. |
| 18056791 |
mTOR signaling pathway is playing a role in the greater synthesis of muscle proteins when resistance exercise is followed by essential amino acids and carbohydrate ingestion |
| 17640392 |
This study identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a new regulator of iron-transferrin uptake |
| 17996122 |
analysis of coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma ce |
| 17928295 |
Bnip3, a hypoxia-inducible Bcl-2 homology 3 domain-containing protein, directly binds Rheb and inhibits the mTOR pathway. |
| 18006825 |
metformin-mediated AMPK activation leads to inhibition of mTOR and a reduction in translation initiation |
| 16818690 |
The higher expressions of mTOR protein was associated with worse outcome in glioblastoma. |
| 17935273 |
Inhibition of mTOR was the idea behind the development of new targeted agents in advanced renal cell carcinoma (Review). | →View more information from publications. |
Recent Publications on FRAP1: |  |
Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a Pten-deficient mouse model of prostate cancer.
Androgen receptors have been shown to play a critical role in prostate... | 8th October, 2009
| Department of Imaging, Merck Research Laboratories, Boston, Massachusetts
| Cancer Res. 2009 Sep 15;69(18):7466-72. Epub 2009 Sep 8.
DOI Direct Link |
Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.
During development, proliferation of cerebellar granule neuron precursors... | 8th October, 2009
| Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer
| Cancer Res. 2009 Sep 15;69(18):7224-34. Epub 2009 Sep 8.
DOI Direct Link |
Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia.
Parkinson's disease (PD), a disorder caused by degeneration of the... | 30th September, 2009
| Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77
| Sci Signal. 2009 Jul 21;2(80):ra36.
DOI Direct Link |
Thwarting dyskinesia by targeting mTORC1.
In a mouse model of Parkinson's disease, new evidence shows that l-DOPA,... | 30th September, 2009
| Center for Neural Science, New York University, New York, NY 10003, USA.
| Sci Signal. 2009 Jul 21;2(80):pe42.
DOI Direct Link |
Get stoned in GABAergic synapses.
During development, proliferation of cerebellar granule neuron precursors... | 24th September, 2009
| Ken Mackie is in the Gill Center and the Department of Psychological &
| Nat Neurosci. 2009 Sep;12(9):1081-3.
DOI Direct Link |
→View more research publications. |
FRAP1 results (if any) from reagent suppliers | 
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Recent Search Terms used to find this page: FRAP1 | frap 1 | storage of mtor protein complex | storage of mtor protein complex | FRAP1 and skeletal muscle | FK506 binding protein 12-rapamycin associated protein 1 | HUMAN MTOR protein | FK506 binding protein 12-rapamycin associated protein 1 FRAP1 | FK506 binding protein 12-rapamycin associated protein 1 | .
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