Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17914450 |
These data implicate activation of mTOR in the pathogenesis of melanoma, and suggest that Rheb and mTOR may be targets for melanoma therapy. |
| 18048359 |
a key regulatory role of the Akt/mTOR pathway in the generation of the effects of As(2)O(3) |
| 17372934 |
Changes in tissue pressure during inflammation may regulate macrophage phagocytosis by activation of PI-3K, which activates Akt2, mTOR, and p70S6K. |
| 18056791 |
mTOR signaling pathway is playing a role in the greater synthesis of muscle proteins when resistance exercise is followed by essential amino acids and carbohydrate ingestion |
| 17640392 |
This study identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a new regulator of iron-transferrin uptake |
| 17996122 |
analysis of coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma ce |
| 17928295 |
Bnip3, a hypoxia-inducible Bcl-2 homology 3 domain-containing protein, directly binds Rheb and inhibits the mTOR pathway. |
| 18006825 |
metformin-mediated AMPK activation leads to inhibition of mTOR and a reduction in translation initiation |
| 16818690 |
The higher expressions of mTOR protein was associated with worse outcome in glioblastoma. |
| 17935273 |
Inhibition of mTOR was the idea behind the development of new targeted agents in advanced renal cell carcinoma (Review). |
| 16912159 |
Mammalian target of rapamycin (mTOR) inhibitor rapamycin enhances the sensitivity of PTEN-deficient tumor cells to the EGFR kinase inhibitor erlotinib |
| 17911267 |
In breast cancer stem-like cells, the STAT3 pathway was found to be positively regulated by mTOR signaling, whereas PTEN served as a negative regulator of both STAT3 and mTOR signaling. |
| 17991864 |
findings suggest that FKBP38 is an endogenous inhibitor of mTOR, whose inhibitory activity is antagonized by Rheb in response to growth factor stimulation and nutrient availability |
| 17724079 |
mTOR inhibition increases eIF4E phosphorylation through a PI3K-dependent and Mnk-mediated mechanism. |
| 17889116 |
Introduction of mTOR inhibitors to the immunosuppressant regimen in heart transplntation may delay renal functional deterioration caused by calcineurin inhibitors. |
| 17018601 |
The TSC/Rheb/mTOR pathway plays a critical role in the regulation of E(2)-induced proliferation. |
| 17595159 |
ULK1 knockdown inhibited rapamycin-induced autophagy consistent with a role downstream of mTOR |
| 17631500 |
the major mechanism of HER2-mediated induction of FASN and ACCalpha in the breast cancer cells used in this study is translational regulation primarily through the mTOR signaling pathway. |
| 17698027 |
Finally, using dual-cistronic luciferase constructs we demonstrate that apoB 5' UTR may have weak internal ribosomal entry (IRES) translation which is not affected by insulin stimulation, and may function to stimulate basal levels of apoB translation. |
| 17683115 |
peptidoglycan make it coincidental the release of arachidonic acid with a rapid induction of cyclooxygenase-2 protein regulated by a signaling cascade involving phosphatidylinositol 3-kinase, mTOR, and the translation machinery |
| 17562705 |
used 401 to test the cellular effect of mTOR inhibition without the complicating side effects on PI3K |
| 17726467 |
PLD1 and phospho-mTOR are coexpressed in a subset of phospho-Akt-negative breast carcinomas. |
| 17604271 |
PRAS40 acts downstream of mTORC1 but upstream of its effectors, such as S6K1 and 4E-BP1 |
| 17363738 |
Withdrawal of Notch signals prevented stimulation of the mTOR pathway by mitogenic factors. These findings collectively suggest that the mTOR pathway is positively regulated by Notch in T-ALL cells |
| 17656678 |
Proarteriosclerotic effects of interferon gamma are associated with mammalian target of rapamycin raptor complex (mTORC1) and PI-3 kinase activiation. |
| 17565979 |
P-Rex1 links mTOR signaling to Rac activation and cell migration |
| 17693255 |
Dysregulation of the tuberous sclerosis 1/mTOR signaling pathway significantly contributes to inflammation-mediated cancer pathogenesis. |
| 17553806 |
mTOR regulates the phosphorylation and activation of Akt in endothelial cells and a major effect of mTOR inhibition in endothelial cells is to suppress Akt-inducible pro-survival signals |
| 17016437 |
In multiple myeloma cells mTOR inhibition results a more complete abrogation of VEGF translation, and ultimately, angiogenesis. |
| 17562865 |
These results strongly suggest that the G1 arrest and the decrease in translation induced by eRF3a depletion are due to the inhibition of mTOR activity and hence that eRF3a belongs to the regulatory pathway of mTOR activity. |
| 17329400 |
ASCT2 silencing inhibits mTORC1 (mTOR/raptor)signaling and leads to growth repression, followed by enhanced survival signaling via mTORC2 (mTOR/rictor)and apoptosis of hepatoma cells. |
| 12150925 |
mTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. |
| 12150926 |
mTOR-catalyzed phosphorylation of 4EBP1 in vitro and mTOR action in vivo require the participation of mTOR binding protein, raptor. |
| 12231510 |
FRAP is a CLIP-170 kinase positively regulating the MT-binding behavior of CLIP-170 |
| 15004009 |
A new form of mTOR elucidates the molecular mechanism underlying mTOR-dependent regulation of RNA synthesis |
| 12820960 |
Rheb is a mediator of MTOR. |
| 14729629 |
K-Ras-mediated transformation of intestinal epitelial cells involves activation of the PI3K/mTOR pathway. |
| 16870609 |
TOR multimerization is a conserved mechanism for TOR functioning |
| 16242075 |
the inhibition of EGFR and mTOR has distinct as well as common signaling consequences in glioblastoma multiforme cells |
| 16959214 |
It would seem that this increase in VEGFR-3 occurred via the ERK and mTOR pathways, since their respective inhibitors U0126, LY294002 or rapamycin were responsible for a decrease of VEGFR-3 |
| 17028174 |
Results suggest that FLCN, mutated in Birt-Hogg-Dube syndrome, and its interacting partner FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. |
| 17075574 |
data demonstrate the ubiquitous activation of the mTOR signaling pathway in post-transplant lymphoproliferative disorder |
| 17114181 |
mTOR-dependent pathways have roles in IFN signaling and 4E-BP1 and TSC1-TSC2 are key components in the generation of IFN-dependent biological responses |
| 17253963 |
model whereby nutrients signal to mTOR via activation of MAP4K3. |
| 15056668 |
an intact PI3K/mTOR pathway is necessary for the ability of IFNalpha to induce apoptosis, whereas activation of the Jak-STAT pathway alone appears to be insufficient for this specific IFNalpha-induced effect |
| 14668532 |
This review describes recent progress in understanding the control of the mTOR signaling pathway and the role of mTOR-interacting proteins. |
| 15723049 |
S6 kinase 1 is essential for the control of muscle cytoplasmic volume by Akt and mTOR |
| 12807916 |
mammalian target of rapamycin regulates STAT1-dependent gene transcription by lipopolysaccharide and interferon-gamma |
| 15632115 |
DGKzeta-derived phosphatidic acid acts as a mediator of mTOR signaling |
| 16786123 |
mTOR may have a role in increasing survival of cervical cancer patients who are treated with cisplatin-based neoadjuvant chemotherapy |
| 16874098 |
Results suggest that lysosomal turnover of GABARAP-PL is activated during the differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway. |
| 16927414 |
activity assays in Hela cells suggested that,in phase G2 and M, the activity of mTOR was maintained at a higher level than in any other phase |
| 15028555 |
PI3K mediates G(1) progression and cyclin expression through activation of an AKT/mTOR/p70S6K1 signaling pathway in the ovarian cancer cells. |
| 15489897 |
PKC-eta targets the Akt and mTOR signaling pathways |
| 15624760 |
Subependymal giant cell astrocytoma cells show high levels of phospho-S6K, phospho-S6, and phospho-Stat3, all proteins downstream of and indicative of mTOR activation. |
| 16098202 |
levels of p-mTOR (Ser2481), and p-4E-BP1 (Thr70 and Ser65) dramatically increase in Alzheimer disease, and are positively significantly correlated with total tau and p-tau |
| 16914728 |
These studies suggest that, through serine phosphorylation, Raptor-mTOR and S6K1 promote the depletion of IRS1 from specific intracellular pools in pathological states of insulin and IGF-I resistance and in lesions associated with tuberous sclerosis. |
| 17289850 |
IGFBP-2 is regulated predominantly through the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway |
| 12271141 |
hamartin and tuberin function together to inhibit mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1) |
| 15899889 |
p70S6 kinase is a major effector of mTOR phosphorylation at Ser-2448 in response to both mitogen- and nutrient-derived stimuli |
| 17102641 |
mTOR is regulatd by polycystin-1 in polycystic kidney disease [review] |
| 14578359 |
Identification of domains of FRAP/mTOR which may mediate its association with the endoplasmic reticulum and the Golgi apparatus. |
| 15218033 |
mTOR regulates PP5, which activates apoptosis signal-regulating kinase 1 signaling |
| 15150271 |
mTOR does not have a role in B-Raf kinase activity regulation by tuberin and Rheb |
| 15292274 |
Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress. |
| 15708965 |
Rrapamycin inhibits fibronectin-induced vascular smooth musscle migration through a pathway that involves mTOR. |
| 12145207 |
Syncytia from cells expressing the HIV-1 Env gene fused with cells expressing CD4/CXCR4 undergo apoptosis after nuclear translocation of mTOR, mTOR-mediated p53 phosphorylation, p53-dependent Bax upregulation & mitochondrial death pathway activation. |
| 15522880 |
mTOR may play a major role in IL-12-induced IFN-gamma production by activated T cells |
| 12080086 |
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E |
| 15623621 |
Overexpression of phospho-mTOR is associated with liver neoplasms |
| 15659381 |
RSPRR motif interacts with a negative regulator of S6K1 that is normally suppressed by mTOR. |
| 17215282 |
inhibition of mTOR by 5'-AMP-activated protein kinase is circumvented |
| 17409838 |
one rational approach for mTOR-targeted lung cancer therapy is to use an mTOR inhibitor in combination with a drug that blocks PI3K/Akt activation such as a PI3K inhibitor, as we demonstrated in our study.21 |
| 17616684 |
IKK alpha controls mTOR kinase activity in Akt-active, PTEN-null prostate cancer cells, with less involvement by IKK beta |
| 12370290 |
mTOR substrate specificity is regulated by serine in the rapamycin binding domain |
| 15317677 |
ANG II activates rapamycin-sensitive mTOR signaling pathway in human coronary smooth muscle cells and involves activation of phosphatidylinositol 3-kinase, p70(S6k), and eukaryotic initiation factor-4E, leading to activation of protein synthesis. |
| 15632201 |
RTP801 and RTP801L work downstream of AKT and upstream of TSC2 to inhibit mTOR functions |
| 12172553 |
These functions of TSC1-TSC2 are mediated by inhibition of the mammalian target of rapamycin (mTOR). |
| 15584862 |
Review. TOR is a transducer of information from various sources, including growth factors, energy sensors, hypoxia sensors, & components regulating growth & division. Blocking TOR mimics amino acid & growth factor deprivation & has a cytostatic effect. |
| 16282343 |
the mTOR pathway plays an important role during megakaryopoiesis by regulating ploidy, cell size, and maturation, in part by regulating p21 and cyclin D3. |
| 16354680 |
Raptor directly binds to and serves as a scaffold for mTOR-mediated phosphorylation of IRS-1 on Ser636/639. |
| 16427044 |
Taken together, these results demonstrate that an intact mTOR pathway is critical for IFN-gamma-induced suppression of pY-STAT3 and apoptosis. |
| 16467080 |
The mTOR protein activation, as measured indirectly by augmented levels of phospho-S6 protein, was more frequent in tumors with gene alterations in either EGFR or KRAS than in their wild-type counterparts. |
| 16543150 |
MSL complex interacts with components of the nuclear pore, in particular Mtor/TPR and Nup153. Knockdown of Mtor or Nup153 results in loss of the typical MSL X-chromosomal staining and dosage compensation in Drosophila male cells but not in female cells. |
| 16912980 |
mTOR kinase hyperactivation is a molecular mechanism underlying the development of cytomegalic neurons |
| 17110454 |
Bcl-3 is required for condensation of fibrin by activated platelets, demonstrating functional significance for mTOR-regulated synthesis of the protein |
| 17470430 |
Rheb signaling to mTOR in vivo requires a Rheb switch 2-dependent interaction with an element other than the three known polypeptide components of TOR complex 1 |
| 12242281 |
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin; These studies position mTOR as an upstream activator of HIF-1 function in cancer cells |
| 15605414 |
diverse control signals converge on the mTOR-S6K1 signaling pathway |
| 15604215 |
mTOR/S6K1 overactivation contributes to elevated serine phosphorylation of IRS-1, leading to impaired insulin signaling to Akt in liver and muscle |
| 16099944 |
T-cad overexpression in vascular endothelial cells protects against stress-induced apoptosis through activation of the PI3K/Akt/mTOR survival signal pathway and concomitant suppression of the p38 MAPK proapoptotic pathway |
| 16141350 |
simultaneous blockade of mTOR and NF-kappaB pathways synergize to significantly inhibit or abrogate the proliferative responses of BM endothelial cells to mitogenic stimuli |
| 16109716 |
phospholipase D suppresses protein phosphatase 2A and is involved in the mTOR survival pathway in the transformation of human cells |
| 16286006 |
mTOR maneuvers on and off the eukaryotic initiation factor 3 translation initiation complex. |
| 11729323 |
phosphatic acid mediated mitogen activation of mTOR signaling |
| 15905173 |
S6 kinase 1 is a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase |
| 16006564 |
Data show that the farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. |
| 16847060 |
the mTOR pathway regulates mitochondrial oxygen consumption and oxidative capacity |
| 16962653 |
Results reveal that the SIN1-rictor-mTOR function in Akt-Ser473 phosphorylation is required for TORC2 function in cell survival but is dispensable for TORC1 function. |
| 17148679 |
These findings suggest that the mTOR signaling pathway is activated and may contribute to cell cycle progression and tumor cell survival in MCL. |
| 17329620 |
Rapamycin stimulates insulin-mediated glucose uptake in men under conditions known to activate the mTOR pathway. |
| 17482291 |
the PI3K/AKT/mTOR signaling pathway is involved in regulation of SphK1, with AKT2 playing a key role in PDGF-induced SphK1 expression |
| 17488873 |
mTOR is inactivated during hypoxia. |
| 17545512 |
analysis of the mammalian target of rapamycin signaling pathway in cancer [review] |
| 12912989 |
TOR-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1 |
| 15388791 |
The rapid activation of PI3K-Akt/PKB-mTOR-p70(S6K) cascade by T3 provides a new molecular mechanism for thyroid hormone action |
| 15576463 |
the mTOR pathway is an important modulator of the signals involved in the acute regulation of insulin-stimulated glucose transport in 3T3-L1 and human adipocytes |
| 15452223 |
Human cytomegalovirus induces mechanisms to maintain the integrity of the eIF4F complex even when mTOR signaling is inhibited. |
| 15001544 |
Activation of hexosamine pathway affects glucose-induced phosphorylation of IRS-1. Impairs coupling of IRS-1 and PI 3-kinase and activativates Akt/mammalian target of rapamycin/phosphorylated heat- and acid-stable protein-1/p70S6 kinase pathway. |
| 16341243 |
HIF1a has a role in determining sensitivity to inhibitors of mTOR in kidney cancer |
| 16652388 |
eukaryotic translation initiation factor 4E binding protein 1(4E-BP1) overexpression is associated with prostate cancer, especially when combined with phosphatase and tensin homolog(PTEN) and mammalian target of rapamycin(mTOR) expression data |
| 16884363 |
Activation of mammalian target of rapamycin is associated with postmenopausal ovarian endometriosis |
| 16916907 |
We demonstrate, for the first time in human skeletal muscle, that the regulation of Akt and its downstream signalling pathways GSK-3beta, mTOR and Foxo1 are associated with both the skeletal muscle hypertrophy and atrophy processes. |
| 16954686 |
levels of mTOR in lymphocytes could follow the cognitive decline in Alzheimer's disease |
| 15878852 |
binding of mTOR to Rheb mutants that are unable to bind guanyl nucleotide in vivo is inhibited by amino withdrawal; inhibitory effect of amino acid withdrawal is exerted through action on mTOR, at a site distinct from that responsible for binding Rheb |
| 11884412 |
Atrophy and hypertrophy of skeletal muscle are associated with decreases and increases in Ser(2448) phosphorylation, a site in the mammalian target of rapamycin (mTOR) phosphorylated by protein kinase B (PKB) in vitro. |
| 12558800 |
the AMPK and mTOR signalling pathways are possibly linked. |
| 16407298 |
mTOR nuclear import is required for its cytoplasmic signaling to S6K1 |
| 14970221 |
Thr2446 as a novel nutrient-regulated phosphorylation site on mTOR |
| 15580312 |
identification of an alternative survival signal that is dependent on phospholipase D and mTOR and is active in a breast cancer cell line where the phosphatidylinositol-3-kinase survival pathway is not active |
| 12604610 |
raptor binds to p70S6k and 4E-BP1 through their respective TOS (conserved TOR signaling) motifs. |
| 15496972 |
stromal cell-mediated apoptotic protection in B-lineage ALL is mediated by PI3K/mTOR and MEK via a synergistic mechanism |
| 15802268 |
EGF and hypoxia induce CXCR4 in non-small cell lung cancer, a process regulated by the PI3-kinase/PTEN/AKT/mTOR signaling pathway and activation of HIF-1alpha |
| 15657358 |
An inhibitor of this and of the EGF receptor pathwway inhibits growth of glioma in a xenograft mousse model. |
| 15702344 |
During recovery, the inhibition of mTOR by AMPK is suppressed, and its activation is maximized by the presence of AA. |
| 16027121 |
activation of mTOR by Akt-mediated cellular energy and inhibition of AMPK is the predominant pathway by which Akt activates mTOR in vivo |
| 16183647 |
A redox-sensitive mechanism regulates the phosphorylation of the raptor-mTOR effector S6K1, the interaction between raptor and mTOR, and the kinase activity of the raptor-mTOR complex. |
| 16929481 |
eIF3i overexpression fosters the integration of growth signals by mTOR into the mRNA translation process, promoting protein synthesis and tumor growth. |
| 16963469 |
Phosphorylated-mTOR levels and mTOR activity were dramatically increased in HEK 293 cells with RIalpha levels reduced by siRNA. |
| 17052453 |
S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt |
| 17318075 |
mTOR pathway is active in 40% of patients with hepatocellular carcinomas undergoing orthotopic liver transplantation |
| 17461779 |
It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 results in the co-immunoprecipitation of other mTORC2 subunits, but not Raptor, a specific component of mTORC1. |
| 17616691 |
AKT amplification and the mTOR/p70S6K1 pathway play an important role in human lung cancer cells acquiring CDDP resistance |
| 12000755 |
Predominant nuclear localization in normal and malignant cells in culture. |
| 12813467 |
mTOR is a critical target for survival signals generated by phospholipase D in breast cancer cells. |
| 15718470 |
results show show that target of rapamycin (TOR) kinase and its associated protein rictor are necessary for AKT/PKB Ser473 phosphorylation and that a reduction in rictor or mammalian TOR (mTOR) expression inhibited an Akt/PKB effector |
| 16049009 |
hVps34 is a nutrient-regulated lipid kinase that integrates amino acid and glucose inputs to mTOR and S6K1 |
| 15953364 |
The mainly anti-apoptotic mTOR signalling is downregulated in cellular and transgenic models of Alzheimer's disease and in peripheral cells of patients, and could contribute to the pathogenesis of the disease. |
| 16824195 |
4E-BP1 binds to eukaryotic initiation factor-4E (eIF4E) to prevent the formation of the active translation complex and dissociates from eIF4E by phosphorylation through the mammalian target of rapamycin (mTOR) in the cells stimulated by amino acids. |
| 16849522 |
Inhibition of mammalian target of rapamycin (mTOR) with rapamycin (10-100 nmol/L) had no significant effect on HIF-1alpha induction in a variety of cell lines, a finding that was confirmed using mTOR siRNA. |
| 17351147 |
A bout of aerobic exercise restores the anabolic response of muscle proteins to insulin by improving endothelial function and Akt/mTOR signaling in older subjects. |
| 17463046 |
mTOR functions as a placental nutrient sensor, matching fetal growth with maternal nutrient availability by regulating placental nutrient transport. Provide a mechanism for the changes in placental leucine transport in intrauterine growth retardation. |
| 17483438 |
vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors |
| 11691993 |
The mTOR pathway is influenced by the intracellular concentration of ATP, independent of the abundance of amino acids, and mTOR itself is an ATP sensor. |
