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ABL1
| Symbol: | ABL1 | | Name(s): | c-abl oncogene 1, receptor tyrosine kinase | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ABL, JTK7, bcr/abl, c-ABL, p150, v-abl | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18059481 |
p210(BCR-ABL) is arranged in discrete foci in the cytoplasm of cell lines and primary CD34(+) cells but not mononuclear cells suggesting the foci may be a feature of immature chronic myeloid leukaemia cells. |
| 17925491 |
requirement of E2F3 for BCR/ABL leukemogenesis |
| 16151465 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18095154 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 18161990 |
Phosphorylation of c-Abl by Pak2 inhibits the interaction between the SH3 domain of Abi2 and the PxxP motif of c-Abl, and the phosphorylation enhances the association of c-Abl with the substrate Crk and increases c-Abl-mediated phosphorylation of Crk. |
| 17604596 |
These results indicate that long-term pre-treatment with Docosahexaenoic acid makes Bcr-Abl HL-60 cells more susceptible to the toxic effect of imatinib. |
| 18036399 |
two cases described here presented a masked t(9;22)(q34;q11.2) in association with a t(19;21); in both cases, the masked Philadelphia chromosome resulted from an insertion of ABL in 22q11, with a proven 22q deletion in one case |
| 18082628 |
These results demonstrate that allele-specific changes in gene expression, with selective, progressive silencing of the wild-type ABL1 allele in favor of the oncogenic BCR-ABL1 allele occur in CML patients with therapy-resistant disease. |
| 17587335 |
Results show that by activating Abl-1 signalling pathway, Anaplasma phagocytophilum protein AnkA facilitates its intracellular infection. |
| 17768119 |
Imatinib mesylate-resistant chronic myelogenous leukemia patients harbor T315I BCR-ABL mutation | →View more information from publications. |
Recent Publications on ABL1: |  |
Correlation of JAK2 V617F mutant allele quantitation with clinical presentation and type of chronic myeloproliferative neoplasm.
Activating JAK2 V617F mutation is present in many patients with chronic... | 3rd November, 2009
| Clinical Pathology Department, William Beaumont Hospital, Royal Oak,
| Ann Clin Lab Sci. 2009 Fall;39(4):345-50.
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New agents in the treatment of chronic myelogenous leukemia.
The discovery of molecularly targeted agents that selectively inhibit... | 3rd November, 2009
| Division of Malignant Hematology, H. Lee Moffitt Cancer Center and
| J Natl Compr Canc Netw. 2009 Oct;7(9):1028-37.
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[Molecular pathogenesis of chronic myeloid leukemia]
Chronic myeloid leukemia (CML) is a paradigm for neoplasias that are... | 29th October, 2009
| Department of Hematology, Dokkyo Medical University School of Medicine.
| Nippon Rinsho. 2009 Oct;67(10):1894-9.
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Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
BACKGROUND: Dysregulation of the cell cycle is a hallmark of many cancers... | 29th October, 2009
| Department of Laboratory Medicine and Pathology, Mayo Clinic College of
| Br J Cancer. 2009 Oct 20;101(8):1461-8. Epub 2009 Sep 8.
DOI Direct Link |
Molecular characterization of chronic myeloproliferative neoplasias in Mexico.
By using novel molecular markers, it is possible to gain information on... | 22nd October, 2009
| Centro de Hematologia y Medicina Interna de Puebla, Mexico.
| Hematology. 2009 Oct;14(5):261-5.
DOI Direct Link |
→View more research publications. |
ABL1 results (if any) from reagent suppliers | 
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