Recent Publications on : |  |
Chronic phase of ETV6-ABL1 positive CML responds to imatinib.
Despite the efficacy of imatinib therapy in chronic myelogenous leukemia,...
Direct Link | 29th October, 2008
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Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML).
Aquaporins (AQPs) have previously been associated with increased...
Direct Link | 22nd October, 2008
| Department of Otolaryngology-Head and Neck Surgery, School of Medicine,
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Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.
Episomes with the NUP214-ABL1 fusion gene have been observed in 6% of...
Direct Link | 17th October, 2008
| [1] 1Hematologic Section of the Human Genetics Centre, Cliniques
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Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: the effect of TLX3/HOX11L2 gene expression on outcome.
Background The prognostic value of the ectopic activation of TLX3 gene...
Direct Link | 7th October, 2008
| Hopital d'Enfants Armand Trousseau APHP.
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Molecular biology of BCR-ABL1-positive chronic myeloid leukemia.
Chronic myelogenous leukemia (CML) has been regarded as the paradigmatic...
Direct Link | 2nd October, 2008
| Department of Leukemia, The University of Texas M.D. Anderson Cancer
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Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization.
Double minute (DM) chromosome is a rare genetic abnormality in leukemia....
Direct Link | 19th September, 2008
| Hematology/Oncology, Cedars-Sinai Medical Center/David Geffen School of
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Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms.
ABL family tyrosine kinases are tightly regulated by autoinhibition and...
Direct Link | 18th September, 2008
| Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90095-1737.
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Therapeutic options against BCR-ABL1 T315I-positive chronic myelogenous leukemia.
Despite the efficacy of imatinib therapy in chronic myelogenous leukemia,...
Direct Link | 17th September, 2008
| Department of Leukemia, The University of Texas M. D. Anderson Cancer
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Reverse transcription with random pentadecamer primers improves the detection limit of a quantitative PCR assay for BCR-ABL transcripts in chronic myeloid leukemia: implications for defining sensitivity in minimal residual disease.
BACKGROUND: Real-time quantitative reverse transcription PCR (RQ-PCR)...
Direct Link | 16th September, 2008
| Division of Haematology, Institute of Medical & Veterinary Science,
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Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases.
The NUP214-ABL1 fusion kinase has recently been identified in 6% of...
Direct Link | 12th September, 2008
| [1] 1Department of Molecular and Developmental Genetics, VIB, Leuven,
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Cryptic and partial deletions of PRDM16 and RUNX1 without t(1;21)(p36;q22) and/or RUNX1-PRDM16 fusion in a case of progressive chronic myeloid leukemia: a complex chromosomal rearrangement of underestimated frequency in disease progression?
Chronic myeloid leukemia (CML) is a myeloproliferative disorder...
Direct Link | 4th September, 2008
| Cancer Research Institute of Lille, JP Aubert Center, Inserm Unit 837,
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Establishment and cytogenetic characterization of a human acute lymphoblastic leukemia cell line (ALL-VG) with ETV6/ABL1 rearrangement.
Fusion kinases (FK) like BCR/ABL1 mediate leukemic transformation and...
Direct Link | 16th August, 2008
| Department of Hematology, JW Goethe University, Frankfurt am Main,
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Kinase activation and transformation by NUP214-ABL1 is dependent on the context of the nuclear pore.
Genetic alterations causing constitutive tyrosine kinase activation are...
Direct Link | 5th August, 2008
| Department of Molecular and Developmental Genetics, VIB, K.U. Leuven,
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FISH mapping of Philadelphia negative BCR/ABL1 positive CML.
ABSTRACT: BACKGROUND: Chronic myeloid leukaemia (CML) is a haematopoietic...
Direct Link | 22nd July, 2008
| Molecular Cytogenetics, Academic Haematology, Royal Free and UCL Medical
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EVI1 activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22).
BACKGROUND: Variant translocations t(9;22) occur in 5 to 10% of newly...
Direct Link | 11th July, 2008
| Centre for Medical Genetics Gent (CMGG), Ghent University Hospital, Ghent,
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