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NR5A1
| Symbol: | NR5A1 | | Name(s): | nuclear receptor subfamily 5, group A, member 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AD4BP, ELP, FTZ1, FTZF1, SF-1, SF1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18182853 |
EID-1 inhibits SF-1. it colocalized with SF-1 in mammalian cells and interacted specifically with the AF-2 domain of SF-1, competing with SRC-1 to inhibit SF-1 transactivation. |
| 17975261 |
Data show that steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells.( |
| 17940071 |
heterozygous partial loss of function mutations in SF1 may be associated with bilateral anorchia ('vanishing testis syndrome') and micropenis in humans |
| 16127213 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16500365 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16564598 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17761949 |
reveal a critical role for SF-1 dosage in adrenocortical tumorigenesis |
| 17694559 |
SF1 mutations are a relatively frequent cause of 46,XY disorders of sex development in humans. |
| 17664281 |
Data show that cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. |
| 17520059 |
Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Beta catenin | nuclear receptor subfamily 5, group A, member 1 | - | - | Pubmed |
| HPRD | catenin, beta 1, 88kDa | Nuclear receptor subfamily 5, group A, member 1 | - | - | Pubmed |
| HPRD | Nuclear receptor subfamily 5, group A, member 1 | jun oncogene | - | - | Pubmed |
| HPRD | Nuclear receptor subfamily 5, group A, member 1 | paired-like homeodomain transcription factor 1 | - | - | Pubmed |
| HPRD | Nuclear receptor subfamily 5, group A, member 1 | receptor interacting protein 140 | - | - | Pubmed |
| HPRD | Nuclear receptor subfamily 5, group A, member 1 | nuclear receptor coactivator 1 isoform 1 | - | - | Pubmed |
| HPRD | Nuclear receptor subfamily 5, group A, member 1 | endothelial differentiation-related factor 1 isoform alpha | - | - | Pubmed |
| HPRD | Nuclear receptor subfamily 5, group A, member 1 | SRY-box 8 | - | - | Pubmed |
| HPRD | Nuclear receptor subfamily 5, group A, member 1 | proline-rich nuclear receptor coactivator 2 | - | - | Pubmed |
| HPRD | nuclear receptor subfamily 5, group A, member 1 | SRC1 | - | - | Pubmed |
Recent Publications on NR5A1: |  |
[SF-1, a key player in adrenal and gonadal differentiation: implications in gonadal dysgenesis and primary ovarian insufficiency.]
Steroidogenic factor 1 (SF-1) gene, identified by Keith Parker in 1992,... | 3rd November, 2009
| Inserm U693, Faculte de Medecine Paris-Sud 11, 94276 le Kremlin Bicetre.
| Ann Endocrinol (Paris). 2009 Sep;70S1:S26-S32.
DOI Direct Link |
cAMP-dependent regulation of CYP19 gene in rabbit preovulatory granulosa cells and corpus luteum.
Transcription of the CYP19 gene encoding the aromatase P450 enzyme in... | 27th October, 2009
| Laboratoire, EA 2608, INRA, USC 2006, Universite, Esplanade de la Paix,
| J Steroid Biochem Mol Biol. 2009 Aug;116(1-2):110-7. Epub 2009 May 19.
DOI Direct Link |
A novel heterozygous mutation of steroidogenic factor-1 (SF-1/Ad4BP) gene (NR5A1) in a 46, XY disorders of sex development (DSD) patient without adrenal failure.
Steroidogenic factor-1 [(SF-1/Ad4BP) (MIM184757)] is a nuclear receptor... | 27th October, 2009
| Department of Pediatrics, Hokkaido University School of Medicine, Sapporo,
| Endocr J. 2009 Aug;56(4):619-24. Epub 2009 Mar 24.
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[NR5A1 and ovarian failure.]
Primary ovarian insufficiency (POI) is characterised by the arrest of... | 24th October, 2009
| A. Bashamboo, C. Ravel, K. McElreavey : Human Developmental Genetics,
| Med Sci (Paris). 2009 Oct;25(10):809-13.
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The expression of the nuclear receptors NR5A1 and NR5A2 and transcription factor GATA6 correlates with steroidogenic gene expression in the bovine corpus luteum.
The corpus luteum (CL) is the major site of progesterone (P4) production... | 20th October, 2009
| Department of Obstetrics and Gynecology, Centre de Recherche en Biologie
| Mol Reprod Dev. 2009 Sep;76(9):873-80.
DOI Direct Link |
→View more research publications. |
NR5A1 results (if any) from reagent suppliers | 
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Human SF-1/NR5A1 MAb (Clone N1665)
Anti-human SF-1/NR5A1 Antibody. FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS. ... Streroidogenic Factor 1 (SF-1, AD4BP, FTZ-F1; NR5A1) is considered an ...
http://www.rndsystems.com/pdf/PP-N1665-00.pdf...
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SF-1 (E-18) Antibody sc-10976
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, NR5A1, 2516, 9q33.3, NM_004959 ...
http://www.scbt.com/datasheet-10976-sf-1-e-18-antibody.html...
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Immunohistochemistry : SF-1/NR5A1 - R&D Systems
SF-1/NR5A1 in rat adrenal gland. Streroidogenic Factor 1 (SF-1) was detected in paraffin-embedded rat adrenal gland tissue sections using anti-human SF-1 ...
http://www.rndsystems.com/ihc_molecule_images.aspx?m=2865...
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SF 1 Gene - Steroidogenic factor 1
Steroidogenic factor 1 - SF1 (Gene NR5A1) Homo sapiens ... Diseases associated with defects or dysregulation of NR5A1 or SF-1 include XY sex reversal, ...
http://www.sigmaaldrich.com/life-science/your-favorite-gene-...
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SF-1/NR5A1 - R&D Systems
Streroidogenic Factor 1 (SF-1, AD4BP, FTZ-F1; NR5A1) is considered an orphan nuclear receptor that belongs to subfamily 5. It was found to be a regulator of
...
http://www.rndsystems.com/molecule_detail.aspx?m=2865...
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SID 7969543 sc-204278
... Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg.med.
Chem. ...
http://www.scbt.com/datasheet-204278.html...
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Dax 1 Gene - Gene NROB1
DAX-1 represses transcription of genes that are regulated by steroidogenic factor-1 (SF-1, NR5A1), Suzuki T, (2003), an orphan nuclear receptor required
for ...
http://www.sigmaaldrich.com/life-science/your-favorite-gene-...
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